A5100402774- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Hepatitis Viruses Studies and Epidemiology
- Adipose Tissue and Metabolism
- Mechanical and Optical Resonators
- Advanced MEMS and NEMS Technologies
- Peroxisome Proliferator-Activated Receptors
- Neuroscience of respiration and sleep
- Ginseng Biological Effects and Applications
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Pain Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Obstructive Sleep Apnea Research
- Biochemical effects in animals
- Muscle metabolism and nutrition
- Amino Acid Enzymes and Metabolism
- Electron Spin Resonance Studies
- Diet and metabolism studies
- Hemoglobin structure and function
- Liver Diseases and Immunity
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Hepatitis C virus research
- Viral Infections and Immunology Research
Hebei Provincial Center for Disease Control and Prevention
2015-2024
Changchun University of Chinese Medicine
2021-2023
Peking University Cancer Hospital
2023
Inner Mongolia Medical University
2022-2023
Peking University
2023
Henan Institute of Science and Technology
2022
East China University of Science and Technology
2021
Academy of Military Medical Sciences
2020
Center for Disease Control
2018-2020
First Affiliated Hospital Zhejiang University
2019
A universal rotavirus (RV) immunization program is a potentially cost-effective measure for preventing RV infection in China. However, the efficacy of only licensed vaccine (Lanzhou lamb vaccine, LLR), which made by domestic manufacturer, has not been proven properly designed clinical trial. In October 2011 to March 2012, potential protection provided LLR, case-control study nested population-based active diarrhea surveillance children <5 years age was conducted rural Zhengding county....
Abstract In this study, we specifically addressed the connection between SARS-CoV-2 virus with host cholesterol metabolism. Plasma lipid profile was measured in 861 COVID-19 patients classified as mild (n=215), moderate (n=364), severe (n=217) or critical (n=65) and 1108 age- sex-matched healthy individuals. We showed that levels of both TG HDL-C were significantly lower disease than disease. After successful treatment, metabolism reestablished infection. The serum concentrations TC can be...
Apoptosis plays an essential role in ischemic stroke pathogenesis.Research on the process of neuronal apoptosis models brain injury seems promising.The growth arrest and DNA-damage-inducible protein 45 beta (Gadd45b) ischemia has not been fully examined to date.This study aims investigate function Gadd45b ischemia-induced apoptosis.Adult male Sprague-Dawley rats were subjected by middle cerebral artery occlusion (MCAO).RNA interference (RNAi) system, which is mediated a lentiviral vector...
Background The hemocyte profile is one of the most frequently requested clinical laboratory tests. However, analysis blood cell indexes obstructive sleep apnea (OSA) patients in previous studies was not comprehensive. And, this study aimed to fully analyze routine OSA patients. Methods A retrospective conducted on 1087 male patients, who were admitted center Nanfang Hospital from May 2013 February 2018. According hypopnea index (AHI), divided into four groups: control group (AHI < 5, n =...
S-Nitrosothiols have been suggested to be mediators of many nitric oxide-dependent processes, including apoptosis and vascular relaxation. Thiol nitrosation is a poorly understood process in vivo, the mechanisms by which oxide can converted into nitrosating agent not established. There discrepancy between biological roles its known chemical physical properties. In this study, we examined formation S-nitrosothiols lipopolysaccharide-treated RAW 264.7 cells. This treatment generated 17.4 +/-...
Enhanced neurogenesis has been reported in the hippocampus of patients with Alzheimer's disease (AD), most common neurodegenerative disorder characterized amyloid-β (Aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. Previously we that phosphorylation played an essential role adult hippocampal neurogenesis, activation glycogen synthase kinase (GSK-3), a crucial kinase, could induce increased neurogenesis. In present study, found treatment D-galactose rats Puerarin...
Background: Alzheimer's disease (AD) is the most common neurodegenerative condition worldwide, with amyloid ß (Aβ) fibrils presenting as its main pathological feature. This study investigated whether Ginsenoside Compound K (CK) has activity against Aβ and mechanism in reducing synaptic damage cognitive impairment. Methods: The binding capacity of CK to Aβ42 Nrf2/Keap1 was determined using molecular docking. Transmission electron microscopy used monitor CK-mediated degradation fibrils. effect...
In the advanced stage of cancer, pain caused by bone metastasis is unbearable, but mechanism cancer (BCP) very complicated and remains unclear. this study, we used 4T1 mouse breast cells to establish a model study BCP. Then paw withdrawal mechanical threshold (PWMT) hematoxylin-eosin staining were reflect erosion on tibia tissue. We also determined role proinflammatory factors (TNF-α, IL-17, etc.) in BCP enzyme-linked immunosorbent assay serum. When GSK690693, new Akt inhibitor, was given...
A novel pressure microsensor is designed, fabricated and tested. Novel piezoresistive sensing structures using 30- mum thick silicon diaphragms (from 370 times to 970 ) meander-shaped piezoresistors are devised. The in this work thicker than that of the conventional sensors extend high-stress distribution into bulk improve device reliability. Piezoresistors partially on obtain high sensitivity linearity. Effects different diaphragm areas, piezoresistor shapes, placing methods performances...
Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer’s disease. Although ginsenoside compound K (CK) protective against neuronal oxidative damage, the underlying remains to be understood. In this study, effects of CK damage induced by hydrogen peroxide HT22 cells were investigated with 1 H nuclear magnetic resonance ( H-NMR)-based metabolomics. The optimal concentration for decreasing nerves was determined MTT assays. (8 μM) significantly increased...
Ankyrins are membrane adaptor molecules that play important roles in coupling integral proteins to the spectrin-based cytoskeleton network. Human mutations of ankyrin genes lead severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. To elucidate evolutionary history ankyrins, we have identified novel sequences insect, fish, frog, chicken, dog, chimpanzee genomes explored phylogenetic relationships gene family. Our data demonstrate duplication occurred at two...
S-nitrosothiols have been implicated as intermediary transducers of nitric oxide bioactivity; however, the mechanisms by which these compounds affect cellular functions not fully established. In this study, we examined effect S-nitrosothiol transport on intracellular thiol status and upon activity a target protein (caspase-3), in bovine aortic endothelial cells. We previously demonstrated that specific amino acid-based (S-nitroso-L-cysteine S-nitrosohomocysteine) occurs via acid system L to...
Puerarin extracted from Radix Puerariae is well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective properties. In this study, we aimed to investigate the effects of puerarin on daunorubicin (DNR)-induced apoptosis H9c2 cells elucidate potential mechanisms involved. MTT assay flow cytometry were performed evaluate cell cytotoxicity apoptosis, respectively. Western blot analysis was used assess changes in expression levels...
Eucommiae Cortex (Eucommia ulmoides Oliver Bark) has been used for anti-osteoporosis usually as an ethnic drug hundred years in China. In this study, a bioactive compound, 5-(hydroxymethyl)-2-furaldehyde (5-HMF), was isolated from Cortex. We found that after rat bone mesenchymal stem cells (bMSCs) were induced by 5-HMF at the concentration of 0.05, 0.10 and 0.20 microg/mL normal medium 7 14 days, mRNA expression ALP, COL1alpha1 (7 days only), OCN OPN increased. However, adipogenic induction...
We investigated the anti-aging effects of velvet antler polypeptide on D-galactose (D-gal)-induced aging mice. D-gal-induced mice were established and randomly divided into five groups, control, model, vitamin E (VE), low-dose high-dose groups. The Morris water maze test was used to evaluate learning memory abilities Hippocampal neurons observed via hematoxylin-eosin staining transmission electron microscopy. Biochemical methods detect activities superoxide dismutase, malonaldehyde other...