A5110377895- Nanoparticle-Based Drug Delivery
- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Bee Products Chemical Analysis
- Bone fractures and treatments
- Berberine and alkaloids research
- Pain Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Skin Protection and Aging
- Acute Ischemic Stroke Management
- Antimicrobial Peptides and Activities
- Inflammatory Myopathies and Dermatomyositis
- Venous Thromboembolism Diagnosis and Management
- Natural product bioactivities and synthesis
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Muscle Physiology and Disorders
- CAR-T cell therapy research
- Acute Kidney Injury Research
- Inflammation biomarkers and pathways
- Neonatal and Maternal Infections
- Patient-Provider Communication in Healthcare
- Natural Compounds in Disease Treatment
China Medical University
2014-2024
Shanxi Jincheng Anthracite Mining Group (China)
2024
Nanjing Drum Tower Hospital
2009-2024
Tangshan People's Hospital
2024
Ningxia Medical University
2023
Chengdu Fifth People's Hospital
2022
Guangdong Pharmaceutical University
2009-2021
Fujian Normal University
2020
Sichuan Agricultural University
2019
Air Force Medical University
2002-2019
Background: Recent studies have shown that bufalin has a good antitumor effect but high toxicity, poor water solubility, short half-life, narrow therapeutic window, and toxic dose is close to the dose, which all limit its clinical application. This study aimed determine targeting efficacy of nanoparticles (NPs) made methoxy polyethylene glycol (mPEG), polylactic-co-glycolic acid (PLGA), poly-L-lysine (PLL), cyclic arginine-glycine-aspartic (cRGD) loaded with bufalin, ie, bufalin-loaded...
MicroRNAs (miRNAs) are small non-coding RNAs that can posttranscriptionally regulate gene expression by targeting messenger RNAs. During miRNA biogenesis, the star strand (miRNA*) is generally degraded to a low level in cells. However, certain miRNA* express abundantly and be recruited into silencing complex expression. Most miRNAs function as suppressive regulators on Group B coxsackieviruses (CVB) major pathogens of human viral myocarditis dilated cardiomyopathy. CVB genome positive-sense,...
We studied the apoptosis-inducing properties of antimicrobial peptide cecropin Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and its underlying mechanism. Proliferation inhibition cells normal liver were determined by MTT assay, viability was trypan blue dye exclusion assay. The apoptotic tumor treated with examined transmission electron microscopy terminal-deoxynucleotidyl transferase mediated nick end labeling. apoptosis rate measured flow cytometry (FCM)...
Berberine is known to inhibit the differentiation of 3T3-L1 cells in vitro, improve glycemic control, and attenuate dyslipidemia clinical study. The aim this study was investigate effects berberine on preadipocytes isolated from human omental fat metabolic syndrome patients treated with for 3 months. We have shown that treatment 10 μ M resulted a major inhibition preadipocyte leptin adiponectin secretion accompanied by downregulation PPAR γ 2, C/EBP α , adiponectin, mRNA expression. After...
Antibiotic resistance/tolerance has become a severe threat to human and animal health. To combat antibiotic-resistant/tolerant bacteria, it is of significance improve the efficacy traditional antibiotics. Here we show that indole potentiates tobramycin kill stationary-phase Staphylococcus aureus cells after short, combined treatment, with its derivative 5-methylindole being most potent compound tested absence ions as prerequisite. Consistently, this treatment also kills various types S....
To explore the differing perspectives of patients and providers their assessment supportive care needs in breast cancer receiving oral chemotherapy.The patient-provider concordance patients' is critical to effective management cancer. Self-administered chemotherapy greatly shifts responsibilities for side-effect monitoring, symptom dose adjustments from provider patient. Home-based plans will be central these patients.A descriptive qualitative design was used.A purposive sample nine...
Purpose: Microencapsulated hepatocytes might solve immunological rejection, broadening a new perspective for the treatment of fulminant hepatic failure (FHF). However, transplantation microcapsulated is limited by low cell viability Nevertheless, co-microencapsulation and human umbilical vein endothelial cells (HUVECs) may make FHF more promising. Methods: We prepared microcapsules using high-voltage electrostatic droplet spray method, transplanted empty microcapsules, isolated hepatocytes,...
A discussion about the correlation between level of serum sodium and sepsis-induced coagulopathy (SIC).
Ischemic stroke (IS) is a detrimental neurological disease and IS lacks valuable methods to recover body function. Indobufen (IND) could alleviate IS. However, the possible mechanism remains undefined.
Background: Surgery remains the front-line therapeutic strategy to treat early hepatocellular carcinoma (HCC). However, 5-year recurrence rates of HCC patients are high. 10- Hydroxycamptothecin (10-HCPT) is a known anti-HCC agent but its poor solubility and bioavailability have limited clinical use. Objective: In this study, we developed novel nanoliposome encapsulated 10-hydroxycamptothecin modified with glycyrrhetinic acid (GA) TAT peptide (GA/TAT-HCPT-LP) for treatment HCC. Dual GA can...
Aims: Research on developing targeted delivery of anticancer drugs for the treatment hepatocellular carcinoma (HCC) is ongoing. This study aimed to synthesize nanoliposomes modified by glycyrrhetinic acid (GA) and ferric tetroxide (Fe3O4) paclitaxel selective specific therapy HCC. Objective: During this project, GA Fe3O4 were used jointly modify active targeting magnetic orientation enhanced HCC improve efficacy, while reducing systemic toxicity side effects drug. Methods: In study,...
Abstract Neither India nor China has a formalized trauma system in place. There are many similarities between the 2 countries terms of size, rapid economic growth, increasing number motor vehicles, and high rates road traffic accident (RTA) fatalities. This paper describes current development elements strategies efforts made to improve India. In China, though not organized formalized, different phases present at varying levels maturity. India, implement by mainly focusing on preventive...
Scope: Four and a half LIM domain protein 2 (FHL2) is expressed in muscle tissue whose deletion causative of myopathies.Although FHL2 has confirmed important role development, its autophagy-related function differentiation not been fully determined.Methods: C2C12 cells were treated with FHL2-konwdown or FHL2-overexpression.The morphology was observed by transmission electron microscopy.The mRNA abundances related genes autophagy measured RT-PCR western blot.Immunofluorescence...
Objective: In this study, we analyzed the differential expression and key signaling pathways of proteins in skin guinea pigs with melanin deposition caused by two different modeling methods utilizing proteomics techniques. Methods: Guinea pig models were: (1) induced ultraviolet (UV) irradiation alone (U group), (2) UV combined progesterone injection (P treated without any treatment were used as blank group (B group). H&E staining Masson to observe extent damage pigs. The differentially...
The present study aimed to investigate the effect of sinomenine hydrochloride (SIN) on cell survival/proliferation in human hepatoma line Huh7, as well determine underlying mechanisms. Three different doses SIN, 140, 280 and 560 µM, were tested. Cellular apoptosis cycle distribution analyzed by flow cytometry. Western blotting was used protein levels apoptosis-associated regulators, cleaved caspase 3, B-cell lymphoma-2 (Bcl-2)-associated X (Bax), Bcl-2 homologous antagonist/killer (Bak)...