Xiaoling Nie

ORCID: 0000-0001-7462-077X
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About
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Research Areas
  • Pharmacological Effects of Natural Compounds
  • Mosquito-borne diseases and control
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Hepatitis B Virus Studies
  • HIV Research and Treatment
  • Nanoparticle-Based Drug Delivery
  • Drug Transport and Resistance Mechanisms
  • Natural product bioactivities and synthesis
  • Malaria Research and Control

Lifetech Scientific (China)
2021

Guangdong Pharmaceutical University
2020

Background: Surgery remains the front-line therapeutic strategy to treat early hepatocellular carcinoma (HCC). However, 5-year recurrence rates of HCC patients are high. 10- Hydroxycamptothecin (10-HCPT) is a known anti-HCC agent but its poor solubility and bioavailability have limited clinical use. Objective: In this study, we developed novel nanoliposome encapsulated 10-hydroxycamptothecin modified with glycyrrhetinic acid (GA) TAT peptide (GA/TAT-HCPT-LP) for treatment HCC. Dual GA can...

10.2174/1568026620666200722110244 article EN Current Topics in Medicinal Chemistry 2020-07-24
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