A5078088913- Mathematical Analysis and Transform Methods
- Image and Signal Denoising Methods
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Digital Filter Design and Implementation
- Ubiquitin and proteasome pathways
- Advanced Algebra and Logic
- Antibiotic Resistance in Bacteria
- Rough Sets and Fuzzy Logic
- Imbalanced Data Classification Techniques
- Matrix Theory and Algorithms
- COVID-19 epidemiological studies
- Ferroptosis and cancer prognosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Sparse and Compressive Sensing Techniques
- Machine Learning in Bioinformatics
- Advanced Topics in Algebra
- Antimicrobial Peptides and Activities
- Advanced Banach Space Theory
- Coronary Interventions and Diagnostics
- Supramolecular Chemistry and Complexes
- Stock Market Forecasting Methods
- Protein Degradation and Inhibitors
- Antimicrobial Resistance in Staphylococcus
Yangzhou University
2024-2025
Second People’s Hospital of Huai’an
2024-2025
Xuzhou Medical College
2024-2025
Hunan University of Science and Engineering
2016-2024
Tsinghua University
2023-2024
North China Electric Power University
2010-2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Chinese University of Hong Kong, Shenzhen
2020-2024
Fuzhou University
2024
Weifang People's Hospital
2024
Protein post-translational modifications (PTMs) play an important role in different cellular processes. In view of the importance PTMs functions and massive data accumulated by rapid development mass spectrometry (MS)-based proteomics, this paper presents update dbPTM with over 2 777 000 PTM substrate sites obtained from existing databases manual curation literature, which more than 235 entries are experimentally verified. This has manually curated 42 new modification types that were not...
The last 18 months, or more, have seen a profound shift in our global experience, with many of us navigating once-in-100-year pandemic. To date, COVID-19 remains life-threatening pandemic little to no targeted therapeutic recourse. discovery novel antiviral agents, such as vaccines and drugs, can provide solutions save human beings from severe infections; however, there is specifically effective treatment confirmed for now. Thus, great attention has been paid the use natural artificial...
Many cell signaling pathways are orchestrated by the weak, transient, and reversible peptide-mediated interactions (PMIs). Here, role of protein context in contributing to stability specificity PMIs is investigated systematically.
The skillful prediction of soil moisture can provide much help for many practical applications including ecosystem management and precision agriculture. It presents great challenges because the future variation has uncertainty. Therefore, a novel encoder-decoder deep learning model with residual based on Long Short-Term Memory (EDT-LSTM) is developed in this study as an alternative data-intelligence tool. This includes two layers: LSTM layer fully connected layer, which used to enhance...
The potentiation of antibiotics is a promising strategy for combatting antibiotic-resistant/tolerant bacteria. Herein, we report that 5-min sublethal heat shock enhances the bactericidal actions aminoglycoside by six orders magnitude against both exponential- and stationary-phase Escherichia coli . This combined treatment also effectively kills various E. persisters, clinical isolates, numerous gram-negative but not gram-positive bacteria enables aminoglycosides at 5% minimum inhibitory...
Recent studies suggested that some HMG-CoA reductase blockers might inhibit the antiplatelet activity of clopidogrel. Therefore, we analyzed how various statins together with a high loading dose clopidogrel (600 mg) affect platelet aggregation.Seventy-seven patients stable angina scheduled for elective coronary stenting were studied. Patients randomized to receive atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin (each 20 mg), cerivastatin (0.3 or placebo, plus 600 mg...
Abstract Ubiquitination is an important post-translational modification, which controls protein turnover by labeling malfunctional and redundant proteins for proteasomal degradation, also serves intriguing non-proteolytic regulatory functions. E3 ubiquitin ligases, whose substrate specificity determines the recognition of target ubiquitination, play crucial roles in ubiquitin–proteasome system. UbiNet 2.0 updated version database UbiNet. It contains 3332 experimentally verified E3–substrate...
Immune checkpoint inhibitors (ICIs) have revolutionized gastrointestinal cancer treatment, yet the absence of reliable biomarkers hampers precise patient response prediction.
An imbalance of antiproliferative BMP (bone morphogenetic protein) signaling and proliferative TGF-β (transforming growth factor-β) is implicated in the development pulmonary arterial hypertension (PAH). The posttranslational modification (eg, phosphorylation ubiquitination) family receptors, including BMPR2 protein type 2 receptor)/ALK2 (activin receptor-like kinase-2) TGF-βR2/R1, receptor-regulated Smads significantly affects their activity thus regulates target cell fate. BRCC3 modifies...
Diabetes is associated with an enhanced collagen-mediated platelet activation that contributes significantly to thromboischemic complications. In this study, the collagen receptor glycoprotein VI (GPVI) was studied in 385 patients type 2 diabetes. Surface expression of Fc forms a functional complex GPVI increased diabetes compared those without (P = 0.02). correlated and found be independently (r 0.529, P < 0.001). Stimulation through specific anti-GPVI monoclonal antibody surface...
Antibiotic resistance/tolerance has become a severe threat to human and animal health. To combat antibiotic-resistant/tolerant bacteria, it is of significance improve the efficacy traditional antibiotics. Here we show that indole potentiates tobramycin kill stationary-phase Staphylococcus aureus cells after short, combined treatment, with its derivative 5-methylindole being most potent compound tested absence ions as prerequisite. Consistently, this treatment also kills various types S....
Abstract The prognosis of lung adenocarcinoma (LUAD) is generally poor. Immunotherapy has emerged as a promising therapeutic modality, demonstrating remarkable potential for substantially prolonging the overall survival individuals afflicted with LUAD. However, there currently lack reliable signatures identifying patients who would benefit from immunotherapy. We conducted comparative analysis two immunotherapy cohorts (OAK and POPLAR) utilized single‐factor COX regression to identify genes...
Only a few states in high-dimensional systems can be identified as (un)steerable using existing theoretical or experimental methods. We utilize semidefinite programming (SDP) to construct dataset for steerability detection qutrit-qutrit systems. For the full-information feature $F_1$, artificial neural networks achieve high classification accuracy and generalization, preform better than support vector machine. As engineering playing pivotal role, we introduce steering ellipsoid-like $F_2$,...
Protein ubiquitylation is an important post-translational modification (PTM), which involves in diverse biological processes and plays essential role the regulation of physiological mechanisms diseases. The Lysine Modifications Database (PLMD) has accumulated abundant ubiquitylated proteins with their substrate sites for more than 20 kinds species. Numerous works have consequently developed a variety prediction tools across all species, mainly relying on predefined sequence features machine...
ABSTRACT Background Immune system modulation has been shown to have a significant impact on attention deficit hyperactivity disorder (ADHD). Mendelian randomization (MR) analysis was used in this study investigate the potential role of different immune cells development ADHD provide therapy and preventative alternatives. Methods In study, 731 risk were examined using publicly accessible genetic data two‐sample MR analysis. Included four types immunological profiles: determinate (DC),...
Improving the efficacy of existing antibiotics is significant for combatting antibiotic resistance that poses a major threat to human health. Carbonyl cyanide m-chlorophenylhydrazine (CCCP), well-known protonophore dissipating proton motive force (PMF), has been widely used block PMF-dependent uptake aminoglycoside and thus suppress lethality. Here, we report CCCP its functional analog FCCP, but not other types protonophores, unprecedently potentiate aminoglycosides (e.g., tobramycin...
Improving the efficacy of existing antibiotics is a promising strategy for combating antibiotic-resistant/tolerant bacterial pathogens that have become severe threat to human health. We previously reported aminoglycoside could be dramatically potentiated against stationary-phase Escherichia coli cells under hypoionic shock conditions (i.e., treatment with ion-free solutions), but underlying molecular mechanism remains unknown. Here, we show mechanosensitive (MS) channels, ubiquitous protein...
Peptibodies represent a new class of biological therapeutics with combination peptide activity and antibody-like properties.Previously, we discovered novel HRH that exhibited dose-dependent angiogenesis-suppressing effect by targeting vascular endothelial growth factor receptors (VEGFRs).Here, computationally designed an antiangiogenic peptibody, termed as PbHRH, fusing the to human IgG1 Fc fragment using first approved peptibody drug Romiplostim template.The biologically active is similar...