A5101473374- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Hydrocarbon exploration and reservoir analysis
- Graphene and Nanomaterials Applications
- Geological and Geophysical Studies
- Reproductive Biology and Fertility
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Geological Studies and Exploration
- 3D Printing in Biomedical Research
- Muscle Physiology and Disorders
- Methane Hydrates and Related Phenomena
- Pancreatic function and diabetes
- Spaceflight effects on biology
- Diabetes Management and Research
- Geological Modeling and Analysis
- Hydraulic and Pneumatic Systems
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Reproductive System and Pregnancy
- Seismic Imaging and Inversion Techniques
- Adipose Tissue and Metabolism
- Supramolecular Self-Assembly in Materials
- Osteoarthritis Treatment and Mechanisms
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2007-2024
Tianjin University
2024
Chengdu University of Technology
2012-2024
Beijing Institute of Education
2007-2023
Beijing Institute of Technology
2023
Sichuan University
2009-2022
West China Hospital of Sichuan University
2022
Nanjing Agricultural University
2022
Academy of Military Medical Sciences
2010-2020
Harbin Institute of Technology
2012-2020
Stem cell implantation strategy has exhibited potential to treat the myocardial infarction (MI), however, low retention and survival limit their applications due reactive oxygen species (ROS) microenvironment after MI. In this study, fullerenol nanoparticles are introduced into alginate hydrogel create an injectable delivery vehicle with antioxidant activity. Results suggest that prepared hydrogels exhibit excellent mechanical strength. addition, fullerenol/alginate can effectively scavenge...
The efficacy of cardiac regenerative strategies for myocardial infarction (MI) treatment is greatly limited by the microenvironment. combination reactive oxygen species (ROS) scavenging to suppress oxidative stress damage and macrophage polarization M2 phenotype in MI microenvironment can be desirable treatment. Herein, melanin nanoparticles (MNPs)/alginate (Alg) hydrogels composed two marine-derived natural biomaterials, MNPs obtained from cuttlefish ink alginate extracted ocean algae, are...
Injectable functional biomaterials have made significant progress in cardiac regenerative. In addition, how to adjust the abominable infarction microenvironment and introduce therapeutic stem cells improve healing effect has become a hotspot. Herein, injectable cell vector is prepared by combining natural alginate hydrogel Au@Pt nanoparticles (Au@Pt/Alg hydrogel) encapsulate brown adipose (BASCs). with both antioxidative conductive properties could effectively eliminate reactive oxygen...
Abstract Introduction Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorate the structure function of injured tissues. The aim this study was to explore therapeutic efficacy ADSC for chemotherapy-induced damage. Methods Female mice were injected intraperitoneally with 50 mg/kg cyclophosphamide (CTX). After 15 consecutive days injection,...
Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function cardiomyocytes in vitro. Here we demonstrated a paradigm construct ECTs for cardiac repair using nanomaterials. Single walled (SWNTs) were incorporated into gelatin hydrogel scaffolds three-dimensional ECTs. We found that SWNTs could provide cellular microenvironment vitro favorable contraction expression electrochemical associated proteins. Upon implantation...
Mesenchymal stem cells, which are poorly immunogenic and have potent immunosuppressive activities, emerged as promising cellular therapeutics for the treatment of several diseases. Mesenchymal-like cells derived from Wharton’s Jelly, called umbilical cord matrix (UCMSCs), reportedly secrete a variety cytokines growth factors, acting trophic suppliers. Here, we used UCMSCs to treat premature ovarian failure (POF). Ovarian function was evaluated by ovulation number follicles. Apoptosis...
Silk fibers spun by silkworms or spiders at ambient temperature display unique mechanical strength, excellent biocompatibility and optical transparency, which offer unconventional interfaces to soft curved biological systems. In comparison with conventional materials, the performance of matter, i.e., animal silks, is mainly determined structure mesoscale. To further extend applications, functionalization silk materials becomes required, mesoscopic material assembly (MMA) was developed for...
A variety of devices used for biomedical engineering have been fabricated using protein polymer because their excellent properties, such as strength, toughness, biocompatibility, and biodegradability. In this study, we an optical waveguide genetically engineered spider silk protein. This method has two significant advantages: (1) recombinant exhibits biological properties (2) biosynthesis can overcome the limitation to research on due low yield natural silk. detail, kinds protein-based...
Myocardial infarction (MI) still represents the "Number One Killer" in world. The lack of functional vasculature infracted myocardium under hypoxia is one main problems for cardiac repair. In this study, a thermosensitive chitosan chloride-RoY (CSCl-RoY) hydrogel was developed to improve angiogenesis after MI. First, RoY peptides were conjugated onto CSCl chain via amide linkages, and our data show that conjugation peptide does not interfere with temperature sensitivity. Then, effect...
The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation stem cells in cardiac tissue engineering.
Cell-based therapy can improve cardiac function but is limited by the low cell retention and survival within ischemic tissues. Injectable tissue engineering aims to support cell-based therapies enhance their efficacy for diseases. So far, no research has been devoted studying usefulness of combination fibrin glue (as scaffold) adipose-derived stem cells (ADSCs) treat myocardial infarction. In our study, rat ADSCs were isolated from subcutaneous adipose The surface phenotype these was...
Objective: This study attempted to reconstruct engineered uterine tissues (EUTs) containing smooth muscle layer, akin the normal wall. Methods: EUTs were reconstructed by seeding epithelial cells on top of constructed stromal layer over layer. A self-made mold was used keep from contraction. At same time, it provided static stretch EUTs. After 14 days culture, structure analyzed histologically and immunohistochemically, or scanning electron microscopy (SEM) transmission (TEM). The expression...
Abstract: Zero-dimensional fullerenes can modulate the biological behavior of a variety cell lines. However, effects and molecular mechanisms proliferation cardiomyogenic differentiation in brown adipose-derived stem cells (BADSCs) are still unclear. In this study, we report initial fullerene-C 60 on BADSCs at different concentrations. Results suggest that has no cytotoxic even concentration 100 µg/mL. Fullerene-C improves MAPK expression level survival, proliferation, cardiomyogenesis....
Zwitterionic dendrimer based unimolecular micelles for anticancer drug delivery were prepared, exhibiting excellent stability in complex biological media.