A5100421455- Bladder and Urothelial Cancer Treatments
- Reproductive Biology and Fertility
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Pediatric Urology and Nephrology Studies
- Advanced Fluorescence Microscopy Techniques
- Kidney Stones and Urolithiasis Treatments
- Urologic and reproductive health conditions
- Cell Image Analysis Techniques
- Renal and related cancers
- Sperm and Testicular Function
- Pelvic floor disorders treatments
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Ureteral procedures and complications
- Fetal and Pediatric Neurological Disorders
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Urinary Bladder and Prostate Research
- Innovations in Medical Education
- Spectroscopy Techniques in Biomedical and Chemical Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Testicular diseases and treatments
Chongqing Medical University
2025
Hubei University
2024-2025
Chinese PLA General Hospital
2023-2024
Guangxi Medical University
2023-2024
Capital Medical University
2022-2024
Shanghai University of Traditional Chinese Medicine
2005-2024
Stomatology Hospital
2021-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2024
University of California, San Francisco
2015-2024
Beijing Tongren Hospital
2024
Objectives To investigate the prevalence and associated factors of kidney stones among adults in China. Subjects Methods A nationwide cross‐sectional survey was conducted individuals aged ≥18 years across China, from May 2013 to July 2014. Participants underwent urinary tract ultrasonographic examinations, completed pre‐designed standardised questionnaires, provided blood urine samples for analysis. Kidney were defined as particles ≥4 mm. Prevalence proportion participants with binary...
Background. Malignant tumors of the salivary glands make up approximately 5% head and neck cancers. The Eastern Cooperative Oncology Group (ECOG) initiated a phase II evaluation paclitaxel in patients with locally recurrent or metastatic gland malignancies. Methods. Chemo-naive histologically confirmed carcinoma origin (mucoepidermoid, adenocarcinoma, adenoid cystic) were eligible. Patients treated paclitaxel, 200 mg/m2 IV, every 21 days for minimum four cycles. Results. Forty-five treated....
Abstract Introduction Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorate the structure function of injured tissues. The aim this study was to explore therapeutic efficacy ADSC for chemotherapy-induced damage. Methods Female mice were injected intraperitoneally with 50 mg/kg cyclophosphamide (CTX). After 15 consecutive days injection,...
No AccessJournal of UrologyPediatric Urology1 Apr 2015Canalization the Urethral Plate Precedes Fusion Folds during Male Penile Development: The Double Zipper Hypothesis Yi Li, Adriane Sinclair, Mei Cao, Joel Shen, Shweta Choudhry, Sisir Botta, Gerald Cunha, and Laurence Baskin LiYi Li More articles by this author , SinclairAdriane Sinclair CaoMei Cao ShenJoel Shen ChoudhryShweta Choudhry BottaSisir Botta CunhaGerald Cunha BaskinLaurence View All Author...
Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles, is an important regulator folliculogenesis and follicle development. Treatment with exogenous MIS in mice suppresses development prevents ovulation. To investigate the mechanisms which inhibits development, we performed single-cell RNA sequencing whole neonatal ovaries treated at birth analyzed postnatal day 6, coinciding first wave growth. We identified distinct transcriptional signatures associated...
Methionine sulfoxide reductase B1 (MsrB1), a member of the selenoprotein family with catalytic site containing selenocysteine (Sec) residue, has been previously identified as an oncogene in colorectal cancer (CRC). However, regulatory mechanisms MsrB1 and link between its oncogenic role antioxidant capacity remain largely unknown. In this study, we demonstrated that exogenous overexpression or knockdown CRC cells led to significant phenotypic alterations, confirming role. To further explore...
In pain relief, lidocaine has gained more attention as a local anesthetic. However, there are several side effects that limit the use of anesthetics. Therefore, it is hypothesized hydrogel system with facile design can be used for prolonged release lidocaine. this study, we developed formulation comprises sodium alginate (SA) and graphene oxide (GO) to prolong The gelation was induced by physically crosslinking Ca2+ ions. formation blank SA GO-reinforced hydrogels investigated different...
Abstract Achieving optimal nutritional status in patients with penetrating Crohn’s disease (CD) is crucial preparing for surgical resection. However, there a dearth of literature comparing the efficacy total parenteral nutrition (TPN) versus exclusive enteral (EEN) optimizing postoperative outcomes. Hence, we conducted case-matched study to assess impact preoperative EEN TPN on incidence adverse outcomes, encompassing overall morbidity and stoma formation, among CD undergoing bowel surgery....
A hydroxyl radical-specific fluorescent probe, CC-7, enables selective, real-time visualization of intracellular ˙OH levels in cancer therapy.
No AccessJournal of UrologyTumor/Trauma/Transplantation1 Apr 2016Canalization the Vestibular Plate in Absence Urethral Fusion Characterizes Development Human Clitoris: The Single Zipper Hypothesis Maya Overland, Yi Li, Mei Cao, Joel Shen, Xuan Yue, Sisir Botta, Adriane Sinclair, Gerald Cunha, and Laurence Baskin OverlandMaya Overland More articles by this author , LiYi Li CaoMei Cao ShenJoel Shen YueXuan Yue BottaSisir Botta SinclairAdriane Sinclair CunhaGerald Cunha BaskinLaurence View All...
Although UDP-glucuronosyltransferase 1A (UGT1A) plays an important role in preventing bladder cancer initiation by detoxifying carcinogenic compounds, its contribution to progression is poorly understood. We immunohistochemically stained for UGT1A specimens. was positive 130/145 (90%; 28 [19%] weak, 53 [37%] moderate, and 49 [34%] strong) urothelial neoplasms, which significantly weaker than matched non-neoplastic tissues (100/101 [99%]; 2 [2%] 17 [17%] 81 [80%] strong). Fifty (98%) of 51...
Gestational diabetes mellitus (GDM) places both the mother and offspring at high risk of complications. Increasing evidence suggests that gut microbiota plays a role in pathogenesis GDM. However, it is still unclear whether related to blood biochemical traits, particularly glucagon-like peptide-1 (GLP-1), GDM patients.To explore correlation between GLP-1, patients.The V4 region 16S ribosomal ribonucleic acid (rRNA) gene was sequenced based on fecal samples 35 pregnant women with compared 25...
Abstract Bone morphogenetic protein 4 (BMP4) is essential for the development of primordial follicles, although its underlying mechanism remains largely unknown. By using cultured ovaries, effects BMP4 and potential signal transduction pathways were investigated. Ovaries from 3‐day‐old female mouse pups maintained in organ culture absence (control) or presence (100 ng/ml). At different time, on follicle growth survival assayed by count TUNEL labeling. The expression phospho‐SMAD1/5/8, Sohlh2...
The functional role of nuclear factor activated T-cells (NFAT), while it has been extensively investigated in the immune system, remains uncertain bladder cancer development. We here aim to assess effects cyclosporine A (CsA) and tacrolimus (FK506), immunosuppressants known specifically inactivate NFAT pathway cells, on neoplastic transformation urothelial cells. Immunohistochemistry revealed that expression levels NFATc1, a isoform shown function as an oncogene sarcoma model, were elevated...
// Takashi Kawahara 1, 2, 3, * , Satoshi Inoue Hiroki Ide 1 Eiji Kashiwagi Shinji Ohtake 3 Taichi Mizushima Peng Li Yi 2 Yichun Zheng Hiroji Uemura George J. Netto Hitoshi Ishiguro Hiroshi Miyamoto Departments of Pathology and Urology, Johns Hopkins University School Medicine, Baltimore, MD, USA Department Laboratory Rochester Medical Center, Rochester, NY, Urology Renal Transplantation, Yokohama City Yokohama, Japan These authors have contributed equally to this work Correspondence to:...
ABSTRACT Spermatogonial stem cells (SSCs) capable of self‐renewal and differentiation are the foundation for spermatogenesis. Although several factors that govern these processes have been investigated, underlying molecular mechanisms not fully elucidated. Here, we investigated role BMP4 in mouse SSC differentiation, found SSCs cultured presence underwent characterized by downregulation markers, Plzf, upregulation marker, c‐kit. Smad1/5/8 proteins were phosphorylated during BMP4‐induced...