A5040500617- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Immune cells in cancer
- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Advanced Proteomics Techniques and Applications
- Metastasis and carcinoma case studies
- Estrogen and related hormone effects
- Urologic and reproductive health conditions
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Risks and Factors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glutathione Transferases and Polymorphisms
- Genetic factors in colorectal cancer
Yokohama City University
2013-2025
Yokohama City University Hospital
2021-2024
University of Rochester Medical Center
2016-2024
Johns Hopkins University
2016-2021
Johns Hopkins Medicine
2016-2021
Tokyo University of Science
2015-2018
Tokyo Women's Medical University Hospital
2015-2018
University of Baltimore
2018
Kanagawa Prefectural Hospital Organization
2018
Kanagawa Cancer Center
2018
To assess the expression status of steroid hormone receptors in upper urinary tract urothelial carcinoma (UUTUC), we immunohistochemically stained for androgen receptor (AR), estrogen receptor-α (ERα), ERβ, glucocorticoid (GR), and progesterone (PR) 99 UUTUC specimens paired non-neoplastic tissues. AR/ERα/ERβ/GR/PR was positive 20%/18%/62%/63%/16% tumors, which significantly lower (except PR) than benign tissues [57% (P < 0.001)/40% = 0.001)/85% 0.001)/84% 0.002)/13% 0.489)]. There were no...
Primary ovarian angiosarcoma is an extremely rare malignant soft tissue tumor that arises from the vascular endothelium, with a limited number of reports. It has no specific symptoms, and it rarely diagnosed in early stages because rapid progression. Furthermore, standard drug therapy available, prognosis poor. The patient was 68-year-old woman suspected having ruptured on plain abdominal computed tomography anemia observed. An emergency laparotomy performed to stop bleeding. Thereafter, one...
Mitochondria contribute to cellular metabolism by providing a specialised milieu for energising cells incorporating and processing the metabolites. However, heterogeneity in mitochondria within is only partially elucidated. dynamically alter their morphology functions during life of animals, which proliferate grow. We here show that Kntc1, highly evolutionarily conserved protein, translocates from Golgi apparatus linear mitochondrial segments (LMS) upon glutamine deprivation plays an...
Abstract Aim Tissue factor pathway inhibitor 2 (TFPI2) is a preoperative biomarker that was developed to discriminate ovarian benign tumors from cancer and covered by health insurance in Japan. The purpose of this study evaluate how the TFPI2 changes after treatment. Methods Serum levels (cut off 191 pg/mL) CA125 35 U/mL) before primary debulking surgery patients with malignant were evaluated among recurrent nonrecurrent cases, respectively. Results A total 46 cases analyzed, including 11...
We investigated the role of NF-κB in development and progression urothelial cancer as well cross-talk between androgen receptor (AR) signals cells. Immunohistochemistry surgical specimens showed that expression levels NF-κB/p65 (P = 0.015)/phospho-NF-κB/p65 < 0.001) were significantly elevated bladder tumors, compared with those nonneoplastic tissues. The rates phospho-NF-κB/p65 positivity also higher high-grade 0.015)/muscle-invasive 0.033) tumors than lower grade/non-muscle-invasive...
We investigated the role of prostaglandin receptors (e.g. E2 receptor 2 (EP2), EP4) and efficacy celecoxib in urothelial tumourigenesis cancer progression.We performed immunohistochemistry bladder (BC) tissue microarrays, vitro transformation assay a normal SVHUC line, western blot/reverse transcription-polymerase chain reaction/cell growth assays BC lines.EP2/EP4 expression was elevated BCs compared with non-neoplastic tissues from those who were resistant to cisplatin-based neoadjuvant...
Androgen receptor (AR) and estrogen receptor-β (ERβ) have been implicated in urothelial tumor outgrowth as promoters, while underlying mechanisms remain poorly understood. Our transcription factor profiling previously performed identified FOXO1 a potential downstream target of AR bladder cancer cells. We here investigated the functional role development progression relation to ERβ signals. In non-neoplastic SVHUC cells or lines, AR/ERβ expression dihydrotestosterone/estradiol treatment...
// Takashi Kawahara 1, 2, 3, * , Satoshi Inoue Hiroki Ide 1 Eiji Kashiwagi Shinji Ohtake 3 Taichi Mizushima Peng Li Yi 2 Yichun Zheng Hiroji Uemura George J. Netto Hitoshi Ishiguro Hiroshi Miyamoto Departments of Pathology and Urology, Johns Hopkins University School Medicine, Baltimore, MD, USA Department Laboratory Rochester Medical Center, Rochester, NY, Urology Renal Transplantation, Yokohama City Yokohama, Japan These authors have contributed equally to this work Correspondence to:...
Although intravesical bacillus Calmette-Guérin (BCG) immunotherapy has been the gold standard for nonsurgical management of non-muscle-invasive bladder cancer, a considerable number patients exhibit resistance to adjuvant treatment with unexplained mechanisms. This study aimed investigate whether and how androgen receptor (AR) signals modulate BCG cytotoxicity in cancer. AR knockdown or overexpression cancer lines resulted induction reduction, respectively, intracellular quantity its...
We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, outgrowth urothelial cancer. In both neoplastic and non-neoplastic cells, expression levels androgen receptor (AR) correlated with those phospho-ATF2. Dihydrotestosterone treatment AR-positive bladder cancer cells also induced phospho-ATF2 phospho-ERK as well nuclear translocation transcriptional activity ATF2. Meanwhile, ATF2 knockdown shRNA...
Emerging evidence indicates that androgen receptor (AR) signaling plays a critical role in the pathogenesis of male-dominant urothelial cancer. Meanwhile, latrophilins (LPHNs), group G-protein-coupled to which spider venom latrotoxin is known bind, remain largely uncharacterized neoplastic diseases. The present study aimed determine functional LPHN3 (encoded by ADGRL3 gene), association with AR signaling, tumorigenesis. In human normal SVHUC cells, overexpression and treatment considerably...
The underlying molecular mechanisms of resistance to cisplatin-based systemic chemotherapy in bladder cancer patients remain be elucidated, while the link between androgen receptor (AR) activity and chemosensitivity urothelial has been implicated. Our DNA microarray analysis control vs. AR knockdown lines identified GULP1 as a potential target signaling. We herein determined relationship expression cells then assessed functional role cisplatin sensitivity. Androgen treatment AR-positive or...
In 2013, the Ministry of Health, Labor, and Welfare (MHLW) in Japan announced a suspension governmental recommendation for routine HPV vaccinations. 2020, MHLW started individual notifications vaccine to targeted girls. April 2022, was restarted, catch-up vaccinations started. We evaluated benefits limitations MHLW's new vaccination strategies by estimating lifetime risk cervical cancer each birth FY under different scenarios suggest measure generation. It revealed that immunization coverage...
Overexpression of atypical protein kinase Cλ/ι ( aPKC λ/ι), a regulator cell polarity, is frequently associated with the poor prognoses several cancers, including gastric cancer. Recent studies revealed molecular link between and KIBRA , an upstream tumor suppressor H ippo pathway that regulates proliferation apoptosis. Further, directly inhibits activity to regulate epithelial polarity. These observations suggest ‐ connection plays role in cancer progression; however, clinical significance...
Abstract Aim The aim of this study was to identify factors that can predict the resistance parenteral therapy in patients with tubo‐ovarian abscesses ( TOA ). Material and Methods We conducted a case–control involving 55 admitted . subjects eligible for included 28 who failed antibiotic required surgery (surgical cases) 27 were conservatively cured (control cases). clinical characteristics on admission reviewed. Logistic regression analysis performed after univariate potentially important...
Although radiotherapy often with chemotherapy has been shown to offer a survival benefit comparable that of radical cystectomy in select patients bladder cancer, the development radiosensitization strategies may significantly enhance its application. Notably, emerging preclinical evidence indicated involvement androgen receptor (AR) signaling urothelial cancer progression. We here assessed whether AR signals could contribute modulating radiosensitivity cells. Ionizing radiation reduced...