A5074483951- Cervical Cancer and HPV Research
- Helicobacter pylori-related gastroenterology studies
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Hepatitis B Virus Studies
- Sarcoma Diagnosis and Treatment
- Reproductive tract infections research
- Gastric Cancer Management and Outcomes
- Vaccine Coverage and Hesitancy
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Endometriosis Research and Treatment
- Management of metastatic bone disease
- Clinical Nutrition and Gastroenterology
- Eosinophilic Esophagitis
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Family Support in Illness
- Ureteral procedures and complications
- Diabetes and associated disorders
- Colorectal and Anal Carcinomas
- Gastroesophageal reflux and treatments
- Kidney Stones and Urolithiasis Treatments
Osaka University
2019-2025
Daiichi Sankyo (United Kingdom)
2025
Soka University
2023
Takarazuka City Hospital
2015-2020
Osaka Women's and Children's Hospital
2016
Hiroshima University
1990-2015
Nihon University
2014
Ehime University
2011
Taisho Pharmaceutical (Japan)
1990
Shizuoka General Hospital
1987
Abstract Objective Systemic platinum‐based chemotherapy is the first‐line treatment of choice for metastatic cervical cancer. While subsequent radiotherapy after primary a potential option, its benefit remains unclear. This multicenter retrospective study aimed to evaluate whether post‐chemotherapy improves prognosis Methods We retrospectively analyzed 46 eligible patients, including 22 patients receiving chemotherapy‐alone and 24 followed by radiotherapy. Medical records were reviewed...
The multicenter, prospective MiroCIP observational study investigated the incidence, risk factors, and outcomes of chemotherapy-induced peripheral neuropathy (CIPN) by oxaliplatin- taxane-based chemotherapies but did not examine their differences in detail. This post hoc subanalysis explored between chemotherapy, terms CIPN symptom profile, severity, response to analgesics. Patients with colorectal, gastric, non-small cell lung, or breast cancer, scheduled receive were followed for 12 months...
The present study created an artificial intelligence (AI)-automated diagnostics system for uterine cervical lesions and assessed the performance of these images AI diagnostic imaging pathological lesions. A total 463 colposcopic were analyzed. traditional colposcopy diagnoses compared to those obtained by image diagnosis. Next, 100 presented a panel 32 gynecologists who independently examined each in blinded fashion diagnosed them four categories tumors. Then, revisited their diagnosis after...
In 2013, the Ministry of Health, Labor, and Welfare (MHLW) in Japan announced a suspension governmental recommendation for routine HPV vaccinations. 2020, MHLW started individual notifications vaccine to targeted girls. April 2022, was restarted, catch-up vaccinations started. We evaluated benefits limitations MHLW's new vaccination strategies by estimating lifetime risk cervical cancer each birth FY under different scenarios suggest measure generation. It revealed that immunization coverage...
We aimed to evaluate the response definitive radiotherapy (RT) for cervical cancer based on histological subtypes and investigate prognostic factors in adenocarcinoma (AC). Of 396 patients treated with RT between January, 2010 July, 2020, 327 met inclusion criteria, including 275 squamous cell carcinoma (SCC) 52 AC restaged 2018 International Federation of Gynecology Obstetrics staging system. Patient characteristics, RT, prognoses SCC were evaluated. The complete (CR) rates 92.4% 53.8% AC,...
The retained products of conception (RPOC) and related conditions (RPOC-ARC) are the main cause secondary postpartum hemorrhage (sPPH), but there is no clear consensus for their management. purpose this study was to characterize those RPOC-ARC that require invasive treatment could be managed more conservatively.We retrospectively analyzed 96 cases occurred after miscarriage, abortion, or delivery at a gestational age between 12 42 completed weeks, were within our institution from May 2015...
In November 2021, the government of Japan announced a reversal its decision in 2013 to suspend previous proactive recommendation for HPV vaccination. However, program young girls receive routine and catch-up vaccinations has not necessarily developed as expected. We conducted nationwide questionnaire survey by mail September 2022. The was mailed 133 municipalities consisting all cities/wards Tokyo Osaka Prefectures other prefectural capital cities. Responses were received from 82 (62.7%)....
To clarify the mechanism of initiation hydrogen ion backdiffusion, effects aspirin and taurocholate, two representative gastric mucosal barrier breakers, on potential difference, secretory activity, energy metabolism, permeability guinea pig mucosa was studied in vitro. 1) The ATP content charge showed a statistically significant reduction when difference decreased to one-half that before addition. 2) acid secretion reduced by addition breaker. 3) However, as measured titrating appearing...
In Japan, in 2013, following reports of several alleged adverse reactions young girls vaccination, the previously successful national human papillomavirus infection (HPV) vaccination program collapsed rapidly. 8 years since rates have hovered near zero. October 2020, an attempt to mitigate this lingering disaster, Japanese Ministry Health, Labor, and Welfare (MHLW) agency finally revised its HPV informational leaflet that was designed be distributed by local governments nationwide. Prior...
Abstract This study aimed to investigate the cytotoxicity of a cluster differentiation 70 antibody‐drug conjugate (CD70‐ADC) against ovarian cancer in vitro and vivo xenograft models. CD70 expression was assessed clinical samples by immunohistochemical analysis. Western blotting fluorescence‐activated cell sorting analyses were used determine lines A2780 SKOV3, cisplatin‐resistant A2780cisR SKOV3cisR. after cisplatin exposure determined cells transfected with mock‐ or nuclear factor...
In Japan, Japan's Ministry of Health, Labor, and Welfare decided to suspend govermental recommendation for HPV vaccination in FY 2013. The rate those born 2000 or thereafter declined dramatically. 2021, the "suspension recommendation" ended. catch-up vaccinations unvaccinated have been offered nationwide from 2022 2024. We aimed quantify intentions characteristics young women now eligible vaccination. METHODS: February 2022, we conducted an internet survey targeted who were 1997-2004 but had...
Borderline ovarian tumors are benign but relatively large that often initially mistaken as cancers. We report three cases of stage I borderline having massive ascites we (preoperatively) suspected being advanced cancer. The patients (35, 47, and 73 years old) reported feeling fullness the abdomen before consulting their gynecologist. By CT scan, they were diagnosed with a pelvic tumor accompanied by ascites, diameters which 11, 20, 11 cm, respectively. Postsurgical pathology showed all...
The HPV vaccination rate in Japan has been dismally low. Our previous survey work found that mothers Japan, who have a strong influence over their daughters, often are receptive to the fathers' participation family's decision-making process about getting daughter vaccinated. We conducted investigate nature of on mother's process. From an internet panel, we selected pool 1,499 eligible had 12-18 years old daughters. were randomized into three Groups. To Group A, gave educational leaflet...
In Japan, the government's recommendation for HPV vaccine has been suspended almost 8 years. A questionnaire survey was conducted in Tsubaki Women's Clinic, Matsuyama, to examine responses of mothers girls eligible before and after their doctor provided them an informative leaflet explaining need cervical cancer prevention.Among 53 who admitted imposing some preconditions being willing encourage daughters' vaccination, 21 (40%) became more vaccinate daughters immediately receiving prevention...
BackgroundAlthough ovarian clear cell carcinoma (CCC) is associated with high incidence of thromboembolism, the clinicopathological and biological significance hypercoagulable status in CCC remains unclear.Materials methodsWe retrospectively analyzed pretreatment D-dimer levels, thromboembolic status, clinical outcome 125 CCCs discovery set 143 two other independent validation sets. Next, we performed RNA sequencing 93 compared coagulation-related gene profiles 2492 pan-cancer data. We...
Endometrial cancer (EC) is a common gynecologic malignancy and patients with advanced recurrent EC have poor prognosis. Although chemotherapy administered for those patients, the efficacy of current limited. Therefore, it necessary to develop novel therapeutic agents EC. In this study, we focused on lipolysis-stimulated lipoprotein receptor (LSR), membrane protein highly expressed in cells, developed chimeric chicken-mouse anti-LSR monoclonal antibody (mAb). This study investigated antitumor...
The Coronavirus Disease 2019 (COVID-19) pandemic has been growing, including in Japan where it estimated that as many 3.1% of patients positive for new CoV strain SARS-CoV-2 might die COVID-19-related respiratory failure. Meanwhile, human papillomavirus (HPV) is spreading Japan. fatality rate HPV-associated cancers after infection with HPV much COVID-19 Japan, although the time to disease longer HPV. Among advanced countries, cervical cancer screening Japanese females very low. Ministry...