A5072099003- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal disorders and treatments
- Helminth infection and control
- Rheumatoid Arthritis Research and Therapies
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Amoebic Infections and Treatments
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Metastasis and carcinoma case studies
- Malaria Research and Control
- Toxoplasma gondii Research Studies
- Research on Leishmaniasis Studies
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Mosquito-borne diseases and control
Nihon University
2013-2025
Teine Keijinkai Hospital
2024
Yokohama Minami Kyosai Hospital
2020
Pharmaceuticals and Medical Devices Agency
2019
Tokyo Metropolitan Tama Medical Center
2011-2016
University of Zurich
2016
Ohkubo Hospital
2015
Hokkaido University
1998-2011
University of Tokyo Hospital
2010
Kobe University Hospital
2008
ABSTRACT Alveolar echinococcosis, which is due to the massive growth of larval Echinococcus multilocularis , a life-threatening parasitic zoonosis distributed widely across northern hemisphere. Commercially available chemotherapeutic compounds have parasitostatic but not parasitocidal effects. Parasitic organisms use various energy metabolic pathways that differ greatly from those their hosts and therefore could be promising targets for chemotherapy. The aim this study was characterize...
Background We have previously evaluated the vaccine efficacies of seven tetraspanins Echinococcus multilocularis (Em-TSP1–7) against alveolar echinococcosis (AE) by subcutaneous (s.c.) administration with Freund's adjuvant. Over 85% liver cyst lesion number reductions (CLNR) were achieved recombinant Em-TSP1 (rEm-TSP1) and -TSP3 (rEm-TSP3). However, to develop an efficient safe human vaccine, efficacy TSP mucosal vaccines must be thoroughly evaluated. Methodology/Principal Findings rEm-TSP1...
ABSTRACT The intraerythrocytic stage of the simian malaria parasite Plasmodium coatneyi (CDC strain) was intravenously inoculated into two species macaques with different susceptibilities to infection this parasite, including four Japanese ( Macaca fuscata ) and three cynomolgus M. fascicularis ). infected P. developed severe clinical manifestations similar those human eventually became moribund, while macaques, natural hosts exhibited no manifestation disease except anemia finally recovered...
The Pallas's squirrel (Callosciurus erythraeus) has invaded fragmented woodlands in urban areas of Kanagawa Prefecture, where frequent human contact occurs. We examined 538 squirrels Hayama-machi, for ectoparasite infestations. A total 1164 lice, 877 fleas, and 231 ticks were retrieved from 297 (55.2%), 338 (62.8%), 135 (25.1%) squirrels, respectively. identified species Neohaematopinus callosciuri, Ceratophyllus anisus, Haemaphysalis flava, hystricis, Ixodes turdus. prevalence N....
Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Recent advances in drug development are providing novel agents for the treatment of RCC, but effects still minimal. In addition, there an urgent need identify diagnostic markers RCC. this report, discover potential therapeutic targets, we subjected RCC samples a quantitative proteomic analysis utilizing 2-nitrobenzenesulfenyl (NBS) reagent. Proteins were extracted from adjacent normal tissue, obtained...
Pallas's squirrel (Callosciurus erythraeus) was introduced in Japan the 1930s and has since established itself several areas across country. Although wild Sciuridae populations have been demonstrated to be potential reservoirs for zoonotic enteric protozoa, epidemiological studies of such pathogens are scarce. Here, we examined 423 fecal samples from squirrels captured Kanagawa Prefecture, Japan, using PCR DNA sequencing determine occurrence Cryptosporidium spp., Enterocytozoon bieneusi,...
ABSTRACT The exact species and/or strains of Leishmania parasites involved strongly influence the clinical and epidemiological features leishmaniasis, current knowledge those influences relationships is inadequate. We report that cytochrome b ( cyt b) gene sequencing identified causal 69 cutaneous leishmaniasis cases in Pakistan over a 3‐year period. Of 21 highland areas (Quetta city, Balochistan province), 16 (76.2%) were as (L.) tropica five (23.8%) major. 48 from lowland areas,...
Faecal samples were collected from the rectum of 540 domestic dogs four districts (Lusaka, Katete, Petauke and Luangwa) in Zambia between 2005 2006 prevalences canine alimentary tract parasites determined by coprological examination. Thirteen different ova including strongyle (43.3%), Spirocerca lupi (18.7%), taeniid (13.1%), Toxocara canis (7.6%), Sarcocystis sp.* (7.5%), Isospora (5.7%), Physaloptera (4.6%), Capillaria (2.8%), Dipylidium caninum (2.2%), Mesocestoides (2.0%), Ascaris...
Changes in the seroprevalence of Dirofilaria immitis infection among shelter dogs between a decade ago and present were evaluated. Serum samples collected from 200 adult urban suburban areas Tokyo, Japan, during two 2-year periods (April 1999 to March 2001 April 2009 2011). Sera tested for presence D. antigen using specific commercialized kit. The was 46% 1999–2001 23% 2009–2011. A decrease observed prevalence 2009–2011; particular, decreased significantly compared with that (P < 0.01)....
This study aimed to determine the prevalence of gastrointestinal parasites in alpacas raised Japan. From December 2010 October 2011, 53 (Vicugna pacos) at a farm Kanto region, Japan, were examined for by 3 fecal tests: direct smear, centrifuged flotation and formalin-ether sedimentation. Eggs Nematodirus sp. found 13.2%, Trichuris 11.3%, Capillaria spp. 5.7%, strongyle-type 50.9% Moniezia 1.9%. Oocysts Eimeria punoensis and/or E. alpacae 69.8%, lamae 1.9% macusaniensis 7.5%. We that Japan...
The present study aimed to search for and characterize parasite molecules, whose expression levels correlate with the viability growth activity of Echinococcus multilocularis metacestodes. We focused on profiles 2 parasite-derived genes, 14-3-3 II/3-10 , as putative molecular markers larval parasite. In experiments in vivo gene were relatively quantified by real-time reverse transcription-PCR using a housekeeping gene, beta-actin reference reaction. All three reactions compared developing...
Alveolar echinococcosis is a refractory disease caused by the metacestode stage of Echinococcus multilocularis. The life cycle this parasite maintained primarily between foxes and many species rodents; thus, dogs are thought to be minor definitive host except in some endemic areas. However, highly susceptible E. multilocularis infection. Because close contact humans, infection with can an important risk human health. Therefore, new measures tools control prevent transmission required. Using...