A5069847628- Malaria Research and Control
- Gastrointestinal motility and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Parasitic Infections and Diagnostics
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Merger and Competition Analysis
- Microtubule and mitosis dynamics
- Toxoplasma gondii Research Studies
- Chronic Lymphocytic Leukemia Research
- Microbial Natural Products and Biosynthesis
- vaccines and immunoinformatics approaches
- Marine Sponges and Natural Products
- Connexins and lens biology
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- dental development and anomalies
- Multiple Myeloma Research and Treatments
Nagasaki Medical Center
2004-2024
Yamagata Prefectural University of Health Sciences
2023-2024
Ehime Prefectural Central Hospital
2011-2022
Saitama Medical University
2018-2022
Social Insurance Saitama Chuo Hospital
2018-2022
Uningá - Centro Universitário Ingá
2020
National Defense Medical College
2012-2018
National Defense Medical College Hospital
2014-2018
Hyogo Medical University
2018
Kyoto University
2018
Previously, we reported the specific occurrence of neutralizing autoantibodies against granulocyte–macrophage colony–stimulating factor (GM-CSF) in bronchoalveolar lavage fluid from 11 Japanese patients with idiopathic pulmonary alveolar proteinosis (I-PAP). The autoantibody was also detected sera all 5 I-PAP examined. To determine that existence is not limited to patients, examined 24 five countries and showed consistently specifically present such patients. Thus, detection can be used for...
Tea polyphenols (flavan-3-ol derivatives) suppressed the oxidative modification of low density lipoprotein (LDL) which is assumed to be an important step in pathogenesis atherosclerosis lesions. Inhibitory experiments on impairment porcine serum LDL by flavan-3-ols were carried out incubating them at 37 degrees C presence 5 microM Cu2+. The oxidation was monitored either absorption increase 234 nm due conjugated diene formation, or formation hydroperoxides and thiobarbituric acid reactive...
We have reported in our previous paper that several flavan-3-ol derivatives (tea polyphenols) inhibited the Cu2+-mediated low density lipoprotein (LDL) oxidation vitro. (-)-Epigallocatechin gallate (EGCG), particular, exhibited strong inhibition. In this study, we compared antioxidative effects of EGCG with those other natural antioxidants, such as flavonols, sesaminol, curcuminoid derivatives, tocopherol analogues, and theaflavins. The were monitored by conjugated diene formation LDL which...
Dolastatin 10, a pentapeptide isolated from the marine mollusk Dolabella auricularia , has antitumor activity. TZT‐1027, dolastatin 10 derivative, is newly synthesized compound. We evaluated its activity against variety of transplantable tumors in mice. Intermittent injections TZT‐1027 were more effective than single or repeated rake with P388 leukemia and B16 melanoma. Consequently, shows schedule dependency. was not only when administered i.p., but also given i.v. However, although active...
TZT-1027, a dolastatin 10 derivative, is an antimicrotubule agent with potent antitumor activity both in vitro and vivo. In this study, we performed biochemical histopathological examinations, evaluated TZT-1027-induced tumoral vascular collapse tumor cell death advanced model, murine colon 26 adenocarcinoma. addition, studied the effects of TZT-1027 on cultured human umbilical vein endothelial cells (HUVEC). Tolerable doses induced tumor-selective hemorrhage within 1 h. This occurred mainly...
Pneumocystis carinii is a pathogen which causes fatal pneumonia in patients with acquired immune deficiency syndrome. To facilitate the basic study of P. carinii, we analyzed major surface proteins by immunochemical and biochemical methods. The protein components both cysts (resting form) trophozoites (vegetative are part group called P115 apparent masses 105 to 120 kilodaltons. They represent an unusually large portion total this organism. purified exhibited six isoelectric variants when...
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of sexual phase in life cycle, T. has an unusual population structure dominated by three clonal lineages predominate North America Europe, (Types I, II, III). These were founded common ancestors ~10,000 yr ago. The recent origin widespread distribution attributed to circumvention cycle new mode transmission—asexual transmission between...
Although certain allergic diseases have been reported to be associated with the prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS), it is unclear whether presence multiple further increases FD IBS. The aim this study determine issue in young people.
TZT‐1027, a derivative of dolastatin 10 isolated from the Indian Ocean sea hare Dolabella auricularia in 1987 by Pettit et al. , is potent antimicrotubule agent. We have compared activity TZT‐1027 with that as well vinca alkaloids vinblastine (VLB), vincristine (VCR) and vindesine (VDS). inhibited microtubule polymerization concentration‐dependently at 1–100 μ M IC 50 values 2.2±0.6 2.3±0.7 respectively. VLB, VCR VDS 1–3 2.7±0.6, 1.6±0.4 1.6±0.2 respectively, but showed slight decrease...
TZT‐1027 (Soblidotin), an antimicrotubule agent, has been demonstrated to show potent antitumor effects, though the relationships among effect, cytotoxicity and anti‐vascular effect of have not studied. We established in vivo human lung vascular‐rich tumor models using a vascular endothelial growth factor‐secreting (SBC‐3/VEGF). SBC‐3/VEGF tumors exhibited high degree angiogenesis comparison with mock transfectant (SBC‐3/Neo) dorsal skinfold chamber model grew much faster larger than...
Apicomplexan parasites are causative agents of various diseases including malaria and have been targets extensive genomic sequencing. We generated 5'-EST collections for six apicomplexa using our full-length oligo-capping cDNA library method. To improve upon the current genome annotations, as well to validate importance physical clone resources, we a large-scale collection cDNAs several parasites.In this study, used total 61,056 5'-end-single-pass sequences from Plasmodium falciparum, P....
Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality morbidity. Resistance to antimalarial drugs a challenging problem in malaria control. Clinical associated with proliferation development Plasmodium parasites human erythrocytes. Especially, into mature forms (trophozoite schizont) falciparum (P. falciparum) causes severe symptoms due distinctive property, sequestration which not shared by any other malaria. Ca2+ well known be...
Angiotensin-converting enzyme (ACE) activity was measured in isolated peripheral blood monocytes and culture medium from 28 patients with sarcoidosis compared values obtained of 25 normal control subjects. ACE determined by radioimmunoassay angiotensin II produced I. While there no measurable or controls under the conditions our study, all showed both cells medium. The mean 2.0 pg formed/min per 10(5) cells, that released into over a 24-h interval 30.4 II/min cells. monocyte activated...