A5020311322- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Medical Imaging Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Radiation Dose and Imaging
- Uterine Myomas and Treatments
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Effects of Radiation Exposure
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
Nara Medical University
2024-2025
Osaka University
2016-2025
Kyoto Prefectural University of Medicine
2022
Nihon University
2022
Kansai Medical University
2022
Hospital Regional de Concepción
2017
Osaka University Hospital
2011-2016
NTT WEST Osaka Hospital
2015
Osaka Medical Center for Cancer and Cardiovascular Diseases
2005-2008
Case Western Reserve University
1978
Androgen deprivation therapy is generally administered alongside radiation for intermediate- or high-risk prostate cancer. However, this treatment results in low testosterone levels, even on a short-term basis. Additionally, after cessation, it may take up to year normal levels return, which deteriorates quality of life. We investigated the time recovery and its association with hormonal This study included 210 patients at our hospital who received low-dose-rate brachytherapy (≤ 6 months)...
Carbon ion radiotherapy has been utilized even for X-ray resistant tumors. However, control of distant metastasis remains a major challenge in carbon irradiation. We investigated whether irradiation combined with dual immune checkpoint blockade therapy (anti-PD-L1 and anti-CTLA-4 antibodies [P1C4]) provides anti-tumor efficacy both local sites. A mouse osteosarcoma cell line (LM8) was inoculated into hind legs C3H mice assigned to four groups: no treatment (NoTX), P1C4, 5.3 Gy one leg...
Positron emission tomography and computed (PET-CT) is widely used to assess the response radiotherapy. However, ability of PET-CT predict treatment failure in human papillomavirus (HPV)-related squamous cell carcinoma head neck (HNSCC) unsatisfactory. We quantified circulating tumor HPV type16 DNA (ctHPV16DNA) using optimized droplet digital PCR 35 patients with HPV16-related HNSCC, who received radiotherapy or without chemotherapy, prospectively correlated ctHPV16DNA metabolic failure....
This study aimed to evaluate the effectiveness and feasibility of reirradiation using high-dose-rate interstitial brachytherapy (HDR-ISBT) in patients with recurrent cervical cancer.The records 52 consecutive women central pelvic recurrence who were salvaged HDR-ISBT-based retrospectively reviewed. Data regarding primary disease, follow-up findings, recurrence, treatment outcome, toxicities collected. Multivariate analysis was performed Cox proportional hazards regression model identify...
To identify groups of patients who derive clinical benefit from postoperative adjuvant concurrent chemoradiotherapy (CCRT), we retrospectively investigated the survival outcomes surgically treated early-stage cervical cancer patients.We reviewed medical records 316 with FIGO stage IB1-IIB had been radiotherapy (RT) (n = 124, RT group) or CCRT 192, after radical hysterectomy between January 1996 and December 2009. Of these, 187 displayed high-risk prognostic factors (high-risk group), 129...
ABSTRACT This study aimed to evaluate the prognostic value of pre-treatment blood cell counts in patients with brain metastasis (BM) from non-small lung cancer (NSCLC) who were treated using linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated radiotherapy (fSRT) a micro-multileaf collimator. Between January 2011 November 2022, 271 consecutive underwent linac-based SRS/fSRT for BM NSCLC. Thirty insufficient test data during this period excluded analysis....
This study aimed to evaluate the clinical outcomes of patients who developed prostate-specific antigen failure after radical prostatectomy and were treated with salvage radiotherapy (SRT). retrospective included 167 received SRT between January 2008 August 2017 at a single center. Cumulative periodic genitourinary gastrointestinal adverse events chronologic changes in quality life evaluated before 1, 3, 6, 12, 24, 36, 48, 60 months SRT. The median follow-up duration was 83 months. 5- 7-year...
High dose rate (HDR) intracavitary brachytherapy (ICBT) with a remote afterloading system plays vital role in the treatment of cervical cancer. We aimed to develop new verification for ICBT cancer and evaluate feasibility clinical plans (PlanClin) generated different afterloaders, applicators techniques. In total, 517 PlansClin patients were treated Elekta 192Ir microSelectron HDR v2r. Reference (PlanRef) applicators. An equation predict total dwell time (Tdwell) PlanClin was by evaluating...
Abstract Objective Systemic platinum‐based chemotherapy is the first‐line treatment of choice for metastatic cervical cancer. While subsequent radiotherapy after primary a potential option, its benefit remains unclear. This multicenter retrospective study aimed to evaluate whether post‐chemotherapy improves prognosis Methods We retrospectively analyzed 46 eligible patients, including 22 patients receiving chemotherapy‐alone and 24 followed by radiotherapy. Medical records were reviewed...
Introduction: The aim of this study was to identify the prognostic factors and establish a model for prediction life expectancy in patients with recurrent cervical cancer that had previously been treated radiotherapy. Methods: records consecutive women after radiotherapy were retrospectively reviewed. Primary disease, follow-up, recurrence data collected. Univariate multivariate analyses survival performed. Results: A total 162 included our database. median 15 months. Multivariate analysis...
It is not well established whether pretreatment (18) F-FDG PET/CT can predict local response of head and neck squamous cell carcinoma (HNSCC) to chemoradiotherapy (CRT). We examined 118 patients: 11 with nasopharyngeal cancer (NPC), 30 oropharyngeal (OPC), 77 laryngohypopharyngeal (LHC) who had completed CRT. parameters primary tumor, including metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum mean standardized uptake value (SUVmax SUVmean ), were correlated response,...
Radiation therapy has been long utilized as localized cancer treatment. Recent studies have also demonstrated that it a distant effect by the enhanced immunity, but rarely occurs. The purpose of this study was to investigate whether X-ray irradiation combined with anti-PD-L1 and anti-CTLA-4 antibodies (P1C4) provides higher probability well local antitumor efficacy for osteosarcoma. LM8 mouse osteosarcoma cells were inoculated into both legs C3H mice assigned one four groups, namely no...
The purpose of this study is to report our clinical outcomes using intensity-modulated radiation therapy (IMRT) for adjuvant treatment cervical cancer, compared with three-dimensional conformal (3DCRT), in terms tumor control, complications and dose-volume histogram (DVH) parameters.Between March 2008 February 2014, 62 patients were treated concurrent nedaplatin-based chemotherapy whole-pelvic external beam (RT). Of these patients, 32 (52%) received 3DCRT 30 (48%) IMRT.The median follow-up...
The aim of this work is to generate synthetic computed tomography (sCT) images from multi-sequence magnetic resonance (MR) using an adversarial network and assess the feasibility sCT-based treatment planning for brain radiotherapy. Datasets 15 patients with glioblastoma were selected 580 pairs CT MR used. T1-weighted, T2-weighted fluid-attenuated inversion recovery sequences combined create a three-channel image as input data. A conditional generative (cGAN) was trained patches. quality...
To evaluate the efficacy and toxicity of paclitaxel plus carboplatin (TC)-based concurrent chemoradiotherapy (CCRT) followed by consolidation chemotherapy in International Federation Gynecology Obstetrics (FIGO) stage IIIB/IVA cervical cancer patients. We reviewed medical records FIGO patients (n=30) who had been intended to be treated with TC-based CCRT (TC-CCRT-group) from April 2012-May 2016. Patients involving a single platinum agent (CCRT-group; n=52) or definitive radiotherapy alone...
Chemoradiotherapy effectively treats superficial esophageal cancer and is optimal to preserve organs. However, late toxicity, particularly in cardiac diseases, obstructs clinical outcomes. We revealed the risk factors for event development post-chemoradiotherapy.Data from 80 patients who were diagnosed with submucosal invasive without metastasis (confirmed using multiple modalities) underwent chemoradiotherapy between 2006 2014 analyzed. Patients 11% (9/80) female, median age follow-up 66.5...