A5102844033- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Advances in Oncology and Radiotherapy
- Effects of Radiation Exposure
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Bone Tumor Diagnosis and Treatments
- Endometrial and Cervical Cancer Treatments
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Vascular Tumors and Angiosarcomas
- Radiation Detection and Scintillator Technologies
- Meningioma and schwannoma management
Osaka University
2015-2024
Fukuoka Tokushukai Hospital
2022-2024
Nozaki Tokushukai Hospital
2022
Osaka Health Science University
2018
Centre for Biomedical Engineering and Physics
2014-2018
Osaka Medical Center for Cancer and Cardiovascular Diseases
2001-2017
Juntendo University Urayasu Hospital
2015
Takarazuka City Hospital
2012-2015
University of Groningen
2012-2015
University Medical Center Groningen
2015
The HyperArc VMAT (HA-VMAT) planning approach was newly developed to fulfill the demands of dose delivery for brain metastases stereotactic radiosurgery. We compared dosimetric parameters HA-VMAT plan with those conventional (C-VMAT).For 23 patients (1-4 metastases), C-VMAT and plans a prescription 20-24 Gy were retrospectively generated, PTV (homogeneity index, HI; conformity CI; gradient GI) tissue (V2Gy-V16Gy) evaluated. Subsequently, physical characteristics (modulation complexity score...
Carbon ion radiotherapy has been utilized even for X-ray resistant tumors. However, control of distant metastasis remains a major challenge in carbon irradiation. We investigated whether irradiation combined with dual immune checkpoint blockade therapy (anti-PD-L1 and anti-CTLA-4 antibodies [P1C4]) provides anti-tumor efficacy both local sites. A mouse osteosarcoma cell line (LM8) was inoculated into hind legs C3H mice assigned to four groups: no treatment (NoTX), P1C4, 5.3 Gy one leg...
Postoperative radiation therapy for thymoma is widely used, although the clinical benefits are controversial. Furthermore, to authors' knowledge, relation between postoperative and cell type classified by World Health Organization (WHO) not known.The records of 324 patients (ages 17-83 years; mean, 51 160 males 164 females) who underwent complete resection a 1970 2005 were reviewed. Mediastinum was performed 134 patients. Survival rates patterns recurrence determined according Masaoka stage...
In stereotactic radiosurgery (SRS) with single-isocentric treatments for brain metastases, rotational setup errors may cause considerable dosimetric effects. We assessed the effects on HyperArc plans single and multiple metastases.For 29 patients (1-8 metastases), a prescription dose of 20-24 Gy that covers 95% (D95% ) planning target volume (PTV) were retrospectively generated (Ref-plan). Subsequently, computed tomography (CT) used Ref-plan cone-beam CT acquired during (Rot-CT) registered....
Radiation therapy has been long utilized as localized cancer treatment. Recent studies have also demonstrated that it a distant effect by the enhanced immunity, but rarely occurs. The purpose of this study was to investigate whether X-ray irradiation combined with anti-PD-L1 and anti-CTLA-4 antibodies (P1C4) provides higher probability well local antitumor efficacy for osteosarcoma. LM8 mouse osteosarcoma cells were inoculated into both legs C3H mice assigned one four groups, namely no...
Abstract The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion lacks a dedicated dose monitor, making control challenging. We developed and characterized monitor for uHDR-scanned beams. Furthermore, simple measurable rate (dose per spot (DR )) was suggested by using experimentally validating quantities relevant to beam. A large plane-parallel ionization chamber (IC) with smaller electrode spacing used reduce recombination effects, operational amplifier...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of double proton exchange in the formamidine-water systemTokio Yamabe, Koichi Yamashita, Meguru Kaminoyama, Masahiko Koizumi, Akitomo Tachibana, and Kenichi FukuiCite this: J. Phys. Chem. 1984, 88, 8, 1459–1463Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/j150652a003https://doi.org/10.1021/j150652a003research-articleACS PublicationsRequest...
Blocking dephosphorylation of eukaryotic translation initiation factor 2α (eIF2α) is reported to alter proliferation and differentiation various cells. Using salubrinal guanabenz as an inhibitory agent eIF2α, we addressed a question whether elevated level phosphorylated eIF2α attenuates malignant phenotypes triple negative breast cancer cells (TNBCs) that lack estrogen receptor, progesterone receptor human epidermal growth receptor-2. We determined effects on in vitro phenotype 4T1 mammary...
Abstract Dopaminergic signaling plays a critical role in the nervous system, but little is known about its potential breast cancer and bone metabolism. A screening of ~1,000 biologically active compounds revealed that selective agonist dopamine receptor D1 (DRD1), A77636, inhibited proliferation 4T1.2 mammary tumor cells as well MDA-MB-231 cells. Herein, we examined effect A77636 on quality using mouse model metastasis from tumor. migration DRD1-dependent fashion suppressed development...
ObjectiveTo retrospectively examine the outcomes of hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannomas.
Background/Aim: The focus of this report is establishing an irradiation arrangement to realize ultra-high dose-rate (uHDR; FLASH) scanned carbon-ion possible with a compact commonly available medical synchrotron. Materials and Methods: Following adjustments the operation it became extract ≥1.0×10<sup>9</sup> carbon ions at 208.3 MeV/u (86 mm in range) per 100 ms. design takes utmost care prevent damage monitors, particularly nozzle, achieved by uHDR beam not passing through part apparatus....
The monochromatic images acquired by Gemstone spectral imaging (GSI) mode on the GE CT750 HD theoretically determines computed tomography (CT) number more accurately than that of conventional scanner. Using former, CT is calculated from (synthesized) monoenergetic X‐ray data. We reasoned image might be applied to radiotherapy treatment planning (RTP) calculate dose distribution accurately. Our goal here was provide electron density (ED) conversion curves with for RTP. Therefore, we assessed...
In radiotherapy treatment planning, intravenous administration of an iodine-based contrast agent during computed tomography (CT) improves the accuracy delineating target volumes. However, increased tissue attenuation resulting from high atomic number iodine may result in erroneous dose calculations because is absent actual procedure. The purpose this proof-of-concept study was to present a novel framework improve using dual-energy virtual unenhanced CT presence agent. Simple phantom...
Abstract Resistance to chemoradiotherapy is one reason for the increased recurrence rate of pancreatic cancer after these therapies. These cells change expression levels several proteins, such as epithelial–mesenchymal transition (EMT), while acquiring chemo- or radio-resistance. In this study, we focused on CD44, a stem cell marker. CD44 has isoforms with different functions: standard isoform (CD44s) and variant (CD44v). However, little known about roles ionizing irradiation. The purpose...
BackgroundTo investigate the treatment results of intracranial meningiomas treated with hypofractionated stereotactic radiation therapy in three to five fractions.