A5090805767- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- COVID-19 Clinical Research Studies
- Free Radicals and Antioxidants
- Glutathione Transferases and Polymorphisms
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- Spaceflight effects on biology
- COVID-19 and healthcare impacts
- Genomics, phytochemicals, and oxidative stress
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
Gunma University
2024
Gunma University Hospital
2019-2024
National Hospital Organization Takasaki Medical Center
2023
Osaka University
2017
Radiation therapy has been long utilized as localized cancer treatment. Recent studies have also demonstrated that it a distant effect by the enhanced immunity, but rarely occurs. The purpose of this study was to investigate whether X-ray irradiation combined with anti-PD-L1 and anti-CTLA-4 antibodies (P1C4) provides higher probability well local antitumor efficacy for osteosarcoma. LM8 mouse osteosarcoma cells were inoculated into both legs C3H mice assigned one four groups, namely no...
Significant numbers of malignant tumor cells that have spread to surrounding tissues and other distant organs are often too small be picked up in a diagnostic test, prevention even such metastases should improve patient outcomes. Using mouse model, we show this article intravenous administration human CCL3 variant carrying single amino acid substitution after mild local hyperthermia not only induces growth inhibition at the treated site but also inhibits metastasis. Colon26 adenocarcinoma (1...
Explorations of the Moon and Mars are planned as future manned space missions, during which humans will be exposed to both radiation microgravity. We do not, however, know health effects for such combined exposures. In a ground-based experiment, we evaluated simulated microgravity on tumorigenesis by performing X-irradiation tail suspension in C3B6F1 ApcMin/+ mice, well-established model intestinal tumorigenesis. Mice were irradiated at 2 weeks age underwent 3 or 11 using special device that...
Abstract Personalized radiotherapy based on the intrinsic sensitivity of individual tumors is anticipated, however, it has yet to be realized. To explore cancer radiosensitivity, analysis in combination with omics data important. The Cancer Cell Line Encyclopedia (CCLE) provides multi‐layer for hundreds cell lines. However, radiosensitivity counterpart lacking. address this issue, we aimed establish a database as assessed by gold standard clonogenic assays, CCLE lines collecting from...
SARS-CoV-2 infection has been associated with a prolonged course and poor prognosis in patients who receive anti-CD20 antibodies. However, there are no established treatments for such patients. Serial changes the antigen titer during clinical treatment strategies immunosuppressed discussed.
Abstract Osteosarcoama is one of the common malignancies at bone in children and adolescent. Recent study demonstrated that combination anti-PD-L1 anti-CTLA-4 antibodies provided grate control metastatic osteosarcoma. However, a strong local treatment strategy including surgery or high precision radiation therapy necessary to elucidate Radiation plays an important role for malignant tumors but previous studies enhanced immune response which not only tumor regression irradiated sites also...