A5015327594- Endometrial and Cervical Cancer Treatments
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Radiation Detection and Scintillator Technologies
- DNA Repair Mechanisms
- Head and Neck Surgical Oncology
- Cancer-related Molecular Pathways
- Bone Tumor Diagnosis and Treatments
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
Gunma University
2016-2025
Gunma University Hospital
2016-2025
Yokohama City Seibu Hospital
2021-2024
Sapporo Kosei General Hospital
2023
St. Marianna University School of Medicine
2021-2022
Fukushima Medical University
2022
Nagoya University
1999-2021
Sendai Kousei Hospital
2015-2021
Sapporo Medical University
2021
University of Toyama
2020
In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which then the world's only heavy accelerator complex dedicated to medical use in hospital environment. Among several types of species, we have chosen ions for cancer therapy because they had most optimal properties terms possessing, both physically and biologically, effective dose-localization body. The purpose investigate efficacy against variety tumors as well develop techniques delivering an...
Carbon ion radiotherapy offers superior dose conformity in the treatment of deep-seated malignant tumours compared with conventional X-ray therapy. In addition, carbon beams have a higher relative biological effectiveness protons or beams. The algorithm planning and beam delivery system is tailored to individual parameters patient. present article reviews available literatures for various disease sites including head neck, skull base, lung, liver, prostate, bone soft tissues pelvic...
PurposeTo evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma head neck (MMHN) in Japan Carbon-Ion Radiation Oncology Study Group study.Methods MaterialsPatients with MMHN N0-1M0 status who were treated RT at 4 institutions between November 2003 December 2014 analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) histologically proven enrolled.ResultsPrimary sites included nasal cavity 178 patients, paranasal...
Carbon ion radiotherapy (C-ion RT) offers superior dose conformity in the treatment of deep-seated tumors compared with conventional X-ray therapy. In addition, carbon beams have a higher relative biological effectiveness protons or beams. C-ion RT for first patient at Gunma University Heavy Ion Medical Center (GHMC) was initiated March 2010. The major specifications facility were determined based on experience clinical treatments National Institute Radiological Sciences (NIRS), size and...
MR Imaging is regarded asthe gold standardfor Image Gudied Adaptive Brachytherapy (IGABT) for cervical cancer. However, its wide applicability limited by availability, logistics and financial implications. Use of alternative imaging like CTand Ultrasound (US) IGABT has been attempted. In order to arrive at a systematic, uniform international approach CT based definition contouring target structures, GEC ESTRO, IBS ABS agreed jointly develop such recommendations on the concepts terms as...
Abstract BACKGROUND The authors performed a long‐term follow‐up study to evaluate the efficacy and late toxicity of high‐dose rate intracavitary brachytherapy (HDR‐ICBT) for cervical carcinoma. METHODS From 1968 1986, 1148 patients with Stage IB IVB squamous cell carcinoma cervix (staging was according International Federation Gynecology Obstetrics) were treated combination external beam radiotherapy (EBRT) HDR‐ICBT. For early‐stage disease, 20 gray (Gy) EBRT delivered whole pelvis, followed...
Abstract Purpose: High linear energy transfer (LET) particles are believed to decrease tumor radiation resistance originating from hypoxia. However, no proof of this effect has been provided by clinical trials and related research. Hence, we investigated the biological aspects high LET carbon beam therapy on cervical cancer. Experimental Design: This study involved 49 patients with stage IIIb bulky IVa cancer treated beams between October 1995 June 2000. Oxygen partial pressure (pO2) was...
Background and purposeA multi-institutional observational study (J-CROS1501PR) has been carried out to analyze outcomes of carbon-ion radiotherapy (CIRT) for patients with prostate cancer.Patients methodsData the enrolled in prospective studies following 3 CIRT institutions were analyzed: National Institute Radiological Sciences (NIRS; Chiba, Japan), Gunma University Heavy Ion Medical Center (GHMC; Gunma, Beam Therapy Center, SAGA HIMAT Foundation (HIMAT; Saga, Japan). Endpoints clinical...
Abstract Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography–based brachytherapy. Eighty Stage IB1–IVA cancer, who had undergone treatment combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 May 2011, were retrospectively analyzed. External beam (50 Gy) central shielding after 20–40 Gy was performed each patient. Cisplatin-based chemotherapy administered concurrently to...
To evaluate the effectiveness of whole-pelvic hyperthermia (HT) added to standard chemoradiotherapy (CRT) in locally advanced cervical cancer (CC), by investigating clinical response and survival patients treated with cisplatin-based CRT vs. HT (CRT + HT).This study was conducted at five hospitals Japan between September 2001 March 2015 International Federation Gynecology Obstetrics stage IB (bulky)-IVA CC undergoing definitive CRT. After giving a written informed consent, were randomly...
To develop a consensus-based guideline as well an atlas defining pelvic nodal clinical target volumes in external beam radiotherapy for uterine cervical cancer.A working subgroup to establish the on cancer was formulated by Radiation Therapy Study Group of Japan Clinical Oncology July 2008. The consisted seven radiation oncologists. process resulting consensus included comparison contouring CT images among members, reviewing published textbooks and relevant literature distribution analysis...
DNA double-strand breaks (DSBs) induced by ionizing radiation pose a major threat to cell survival. The can respond the presence of DSBs through two repair pathways: homologous recombination (HR) and nonhomologous end joining (NHEJ). Higher levels death are high-linear energy transfer (LET) when compared low-LET radiation, even at same physical doses, due less effective efficient repair. To clarify whether high-LET inhibits all pathways or specifically one pathway, studies were designed...
The purpose of this study was to compare carbon ion radiotherapy (C-ion RT) and stereotactic (SBRT) with photon beams for the treatment hepatocellular carcinoma (HCC), specifically regard dose volume parameters target coverage normal tissue sparing. Data 10 patients who were treated using C-ion RT a total 60 Gy(RBE) in four fractions used. virtual plan SBRT simulated on planning computed tomography images RT. Dose such as minimum covering 90 % (PTV D90), homogeneity index (HI), conformity...
Abstract Carbon ion radiotherapy shows great potential as a cure for X-ray-resistant tumors. Basic research suggests that the strong cell-killing effect induced by carbon ions is based on their ability to cause complex DNA double-strand breaks (DSBs). However, evidence supporting formation of DSBs in actual patients lacking. Here, we used advanced high-resolution microscopy with deconvolution show are formed human tumor clinically treated radiotherapy, but not X-ray radiotherapy....
Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) 3D image-guided brachytherapy (3D-IGBT) cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology initiated guideline development CT-based CTVHR (based on a comprehensive literature review as well experience) July 2014. Extensive discussions occurred during four face-to-face...
To evaluate the contribution of thermal dose parameters during regional hyperthermia (HT) treatment to clinical outcomes in patients with cervical carcinoma (CC) who received chemoradiotherapy (CRT) plus HT.Data from a multicentre randomised trial concurrent CRT + HT vs. alone were used efficacy and safety this combination therapy CC patients. The intrarectal temperatures undergoing recorded. complete data 47 (92%) 51 group available for analysis. Thus, included present study.Among HT,...
To evaluate the safety and efficacy of carbon-ion radiation therapy (C-ion RT) for locally advanced sinonasal malignant tumors in a multicenter retrospective study (J-CROS 1402 HN).Clinical data were collected patients who had stage N0-1M0 received C-ion RT at 4 institutions Japan between November 2003 December 2014. Of 458 patients, 393 naïve 65 recurrent tumors. The located nasal cavity (n = 263), maxillary sinus 109), ethmoid 71), other locations 15). histologic types mucosal melanoma...
Abstract Background & Aims Carbon‐ion radiation therapy has shown encouraging results in hepatocellular carcinoma patients single‐centre studies. We evaluated the effectiveness and safety of short‐course carbon‐ion for a multicentre study conducted by Japan Carbon Ion Radiation Oncology Study Group. Methods Consecutive who were treated with four or fewer fractions at Japanese institutions between April 2005 November 2014 analysed retrospectively. The primary outcome was overall survival;...