A5012910042- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bone Tumor Diagnosis and Treatments
- Endometrial and Cervical Cancer Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Effects of Radiation Exposure
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Detection and Scintillator Technologies
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cervical Cancer and HPV Research
- Boron Compounds in Chemistry
- Ear and Head Tumors
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Oral and Maxillofacial Pathology
Kanagawa Prefectural Hospital Organization
2020-2024
Kanagawa Cancer Center
2020-2024
National Institutes for Quantum Science and Technology
2013-2023
Nihon University
2021
Chiba University
2004-2019
Tokai University
2018
Centro di Riferimento Oncologico
2016
Helmholtz-Zentrum Dresden-Rossendorf
2016
German Marine Research Consortium
2016
German Cancer Research Center
2016
At the National Institute of Radiological Sciences (NIRS), more than 8,000 patients have been treated for various tumors with carbon-ion (C-ion) radiotherapy in past 20 years based on a radiobiologically defined clinical-dose system. Through clinical experience, including extensive dose escalation studies, optimum dose-fractionation protocols established respective tumors, which may be considered as standards C-ion radiotherapy. Although therapeutic appropriateness system has widely...
To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with unresectable bone soft tissue sarcomas.We conducted a phase I/II dose escalation study radiotherapy. Fifty-seven 64 sites sarcomas not suited resection received Tumors involved spine or paraspinous tissues 19 patients, pelvis 32 extremities six patients. The total ranged from 52.8 to 73.6 gray equivalent (GyE) was administered 16 fixed fractions over 4 weeks (3.3 4.6 GyE/fraction). median tumor size...
In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which then the world's only heavy accelerator complex dedicated to medical use in hospital environment. Among several types of species, we have chosen ions for cancer therapy because they had most optimal properties terms possessing, both physically and biologically, effective dose-localization body. The purpose investigate efficacy against variety tumors as well develop techniques delivering an...
The authors summarized the outcomes of patients with unresectable osteosarcoma trunk who received carbon ion radiotherapy (CIRT).The performed a retrospective analysis 78 had medically inoperable and treatment CIRT between 1996 2009. Tumor sites included pelvis in 61 patients, spine paraspinal region 15 other 2 patients. median applied dose was 70.4 Gray equivalent (GyE) total 16 fixed fractions over 4 weeks.The minimum duration follow-up for survivors 14 months. Forty-eight remained alive....
PurposeTo evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma head neck (MMHN) in Japan Carbon-Ion Radiation Oncology Study Group study.Methods MaterialsPatients with MMHN N0-1M0 status who were treated RT at 4 institutions between November 2003 December 2014 analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) histologically proven enrolled.ResultsPrimary sites included nasal cavity 178 patients, paranasal...
The biological effect of charged-particle beams depends on both dose and particle spectrum. As one the physical quantities describing spectrum beams, we considered linear energy transfer (LET) throughout this study. We investigated a new therapeutic technique using two or more ion species in treatment session, which call an intensity modulated composite therapy (IMPACT), for optimizing dose-averaged LET distributions patient as its proof principle. Protons helium, carbon, oxygen ions were...
In carbon ion radiotherapy there is an urgent clinical need to develop objective tools for the conversion of relative biological effectiveness (RBE)-weighted doses based on different models. this work we introduce a clinically oriented method compare NIRS-based and LEM-based GyE systems, minimizing differences in physical dose distributions between treatment plans. Carbon plans were optimized target volumes cubic spherical shapes, RBE-weighted prescription levels ranging from 3.6 4.4 GyE....
Although carbon ion therapy facilities are expensive, the biological effects of beam treatment may be better against cancer (and stem cells) than a photon beam. To investigate whether have advantage over X-rays by targeting stem-like cells, human colon cells were used in vitro and vivo. The relative effectiveness (RBE) values to at D10 from 1.63 1.74. Cancer CD133(+), CD44(+)/ESA(+) had greater ability for colony spheroid formation, as well vivo tumorigenicity compared with CD133(-),...
Abstract Purpose: The purpose is to evaluate the efficacy and toxicity of carbon ion radiotherapy for unresectable sacral chordomas. Experimental Design: We performed a retrospective analysis 30 patients with chordomas treated at Heavy Ion Medical Accelerator in Chiba, Japan. Twenty-three presented no prior treatment, remaining 7 had locally recurrent disease following previous surgical resection. median clinical target volume was 546 cm3. applied dose ranged from 52.8 73.6 GyE (gray...