A5102724200- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Radiation Detection and Scintillator Technologies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Medical Imaging and Pathology Studies
- Management of metastatic bone disease
- Cervical Cancer and HPV Research
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Chiba Rosai Hospital
2017-2024
National Institutes for Quantum Science and Technology
2008-2024
National Hospital Organization
2007-2024
Nagara Medical Center
2007-2024
Pulmonary Associates
2009
Tokai University
2001-2006
Chiba Hospital
2006
Chiba University
1996-2003
Gifu University
1994-2002
Numazu City Hospital
2001
In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which then the world's only heavy accelerator complex dedicated to medical use in hospital environment. Among several types of species, we have chosen ions for cancer therapy because they had most optimal properties terms possessing, both physically and biologically, effective dose-localization body. The purpose investigate efficacy against variety tumors as well develop techniques delivering an...
Carbon-ion radiotherapy (C-ion RT) possesses physical and biological advantages. It was started at NIRS in 1994 using the Heavy Ion Medical Accelerator Chiba (HIMAC); since then more than 50 protocol studies have been conducted on almost 4000 patients with a variety of tumors. Clinical experiences demonstrated that C-ion RT is effective such regions as head neck, skull base, lung, liver, prostate, bone soft tissues, pelvic recurrence rectal cancer, well for histological types including...
Abstract BACKGROUND: The authors evaluated the tolerance and efficacy of carbon‐ion radiotherapy (CIRT) as a short‐course, preoperative treatment determined recommended dose needed to reduce risk postoperative local recurrence without excess injury normal tissue. METHODS: Patients radiographically defined with potentially resectable pancreatic cancer were eligible. A preoperative, dose‐escalation study was performed fixed 8 fractions in 2 weeks. irradiation increased by 5% increments from 30...
BACKGROUND The objective of this study was to evaluate the safety and efficacy carbon‐ion radiotherapy (CIRT) in patients with hepatocellular carcinoma (HCC) stepwise dose escalation hypofractionation 2 combined prospective trials. METHODS Sequential phase 1/2 (protocol 9603) 0004) trials were conducted for histologically proven HCC. 1 component protocol 9603 a dose‐escalation study; CIRT delivered 12, 8, or 4 fractions. After determination recommended dose, performed an expanded cohort,...
<b>Background:</b> Recently, transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS–FNA) has been evaluated for mediastinal nodal staging (N staging) of lung cancer, as this technique is less invasive than mediastinoscopy and possibly more accurate 18F-fluorodeoxyglucose positron emission tomography with computed (PET–CT). However, EUS–FNA does not provide access to pretracheal hilar lymph nodes. More recently, endobronchial transbronchial needle (EBUS–TBNA) introduced a...
<b>Background and study aims:</b> The aim of the current was to assess detection rate right adrenal gland diagnostic ability endoscopic ultrasound (EUS) fine-needle aspiration (FNA) for diagnosis metastasis in potentially resectable lung cancer. <b>Patients methods: </b>This retrospective cohort included a consecutive series 150 patients undergoing EUS/EUS – FNA staging by EUS accuracies computed tomography (CT), positron emission tomography-CT (PET-CT), were evaluated. <b>Results:</b>...
Abstract Background & Aims Carbon‐ion radiation therapy has shown encouraging results in hepatocellular carcinoma patients single‐centre studies. We evaluated the effectiveness and safety of short‐course carbon‐ion for a multicentre study conducted by Japan Carbon Ion Radiation Oncology Study Group. Methods Consecutive who were treated with four or fewer fractions at Japanese institutions between April 2005 November 2014 analysed retrospectively. The primary outcome was overall survival;...
Abstract Background Carbon‐ion radiotherapy (CIR) has been under development. We report the results of a phase I/II clinical trial preoperative CIR for esophageal squamous cell carcinoma (ESCC). Methods Thirty‐one thoracic ESCC patients were enrolled. They first treated with CIR. The radiation dose was escalated from initial 28.8 GyE up to 36.8. Four 8 weeks after followed by evaluation therapy, surgery performed. Thereafter, pathological made. Results Acute toxicity not seen except in one...
Amplitude-based gating aids treatment planning in scanned particle therapy because it gives better control of uncertainty with the gate window. We have installed an X-ray fluoroscopic imaging system our room for clinical use amplitude-based strategy. evaluated effects this under realistic organ motion conditions using 4DCT data lung and liver tumors. was done 24 patients area-detector CT. calculated field-specific target volume (FTV) window, which defined a single respiratory cycle....
The aim of this study was to determine by radioisotope use whether the sentinel lymph node concept is applicable esophagogastric cancers. In addition, we examined radioactivities hot nodes and compared them with sensitivity a gamma probe.The subjects were 44 patients, 23 esophageal cancer 21 gastric cancer. day before surgery, patients underwent endoscopic submucosal injection 184 MBq Tc-99m tin colloids into sites surrounding tumor. Radioisotope activities dissected at surgery measured...
Hepatocellular carcinoma (HCC) patients with Child-Pugh (CP)-B not eligible for surgery nor other focal therapy options due to impaired liver function, have very limited treatment options. This study aims retrospectively investigate the toxicity and efficacy of Carbon-ion radiotherapy (C-ion RT) on HCC CP-B patients.Patients CP-B, no extrahepatic metastasis, treated C-ion RT between May 2000 March 2020 were extracted included in this study.Sixty-nine lesions 58 included. The median follow-up...
Prognosis is usually grim for those with liver metastasis from colorectal cancer ( CRC ) who cannot receive resection. Radiation therapy can be an option unsuitable resection, carbon ion radiotherapy CIRT being more effective and less toxic than X‐ray due to its physio‐biological characteristics. The objective of this study identify the optimal dose single fraction metastasis. Thirty‐one patients were enrolled in present study. Twenty‐nine received a single‐fraction , escalating 36 Gy RBE 5%...
Phase-controlled rescanning of the carbon-ion beam offers fast and precise dose application with decreased irradiation normal tissue. However, organ movement respiration remains a unique challenge. Technological development has enabled simultaneous beam-energy-modulated markerless phase-controlled gating, allowing scanning treatment respiration-mobile tumors carbon. A total 10 patients in liver or lung were treated feasibility study at our facility using this combination. At median 10.5...