A5002633417- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- IgG4-Related and Inflammatory Diseases
- Cell Adhesion Molecules Research
- Chronic Kidney Disease and Diabetes
- Autoimmune and Inflammatory Disorders Research
- Renal and related cancers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Rheumatoid Arthritis Research and Therapies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Tyrosine Phosphatases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis C virus research
- Galectins and Cancer Biology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Liver Diseases and Immunity
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hormonal Regulation and Hypertension
- Immune cells in cancer
University of Occupational and Environmental Health Japan
2025
Gunma University
2015-2024
Keio University
2024
Gifu University
2023
ChemoCentryx (United States)
2023
Gunma University Hospital
2022
Memorial University of Newfoundland
2020
Jichi Medical University
2012
University of Miyazaki Hospital
2012
Kirin (Japan)
2005
Interleukin-22 (IL-22) is a novel cytokine of the IL-10 family. Although its pathophysiologic function largely unknown, induction acute-phase responses by IL-22 has suggested proinflammatory properties. In this study, we sought to examine whether plays role in pathogenesis rheumatoid arthritis (RA).Expression and receptor 1 (IL-22R1) was examined reverse transcription-polymerase chain reaction (RT-PCR), Western blot, immunohistochemical analysis. The effects recombinant (rIL-22) on cultured...
Abstract Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) is a transmembrane that expressed predominantly in macrophages. Its extracellular region interacts with the ligand CD47 on surface of adjacent cells, and its cytoplasmic binds phosphatases SHP-1 SHP-2. Phagocytosis IgG- or complement-opsonized RBCs by peritoneal macrophages derived from mice express mutant SHPS-1 lacks most was markedly enhanced compared apparent wild-type This effect not...
Sulfite, which is known as a major constituent of volcanic gas, endogenously produced in mammals, and its concentration serum increased patients with pneumonia. It has been reported that sulfite by oxidation from hydrogen sulfide (H2S) an intermediate the mammalian body. The objective this study was to investigate ability reactive oxygen species neutrophils produce H2S. Sulfite production activated stimulated N-formyl-methionyl-leucyl-phenylalanine gradually sodium hydrosulfide (NaHS)...
Abstract: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by increased platelet clearance because of antiplatelet antibodies. It was recently reported that the balance T helper 1 (Th1) and 2 (Th2) subsets has been implicated in regulation many responses. In this study, intracellular interleukin‐4 interferon‐ γ production CD4 + T‐lymphocytes activated phorbol 12‐myristate 13‐acetate ionomycin assessed via flow cytometry order to determine clinical...
Objectives. To determine if the International Society of Nephrology/Renal Pathology (ISN/RPS) 2003 classification lupus nephritis (LN) is helpful in predicting renal outcome. Methods. A total 92 patients with LN who underwent biopsy our hospital were re-classified according to ISN/RPS criteria. Results. The mean patient age was 36.8 yrs and median observation period 65 months. relative frequency for each class as follows: Class I (minimal mesangial LN) 0%, II (mesangial proliferative 13%,...
Objective. IL-19 is a novel cytokine of the IL-10 family. In this study, we sought to examine whether plays role in pathogenesis RA. Methods. Expression IL-19, IL-20 receptor 1 (IL-20R1) and IL-20R2 was examined by RT-PCR immunohistochemical analysis rheumatoid synovium. The effects on synovial cells established from synovium (RASCs), with regard IL-6 production signal transducers activators transcription3 (STAT3) activation, were ELISA western blot analysis, respectively. effect RASC...
<b>Background:</b> Recently, transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS–FNA) has been evaluated for mediastinal nodal staging (N staging) of lung cancer, as this technique is less invasive than mediastinoscopy and possibly more accurate 18F-fluorodeoxyglucose positron emission tomography with computed (PET–CT). However, EUS–FNA does not provide access to pretracheal hilar lymph nodes. More recently, endobronchial transbronchial needle (EBUS–TBNA) introduced a...
Dendritic cells (DCs) promote immune responses to foreign Ags and tolerance self-Ags. Deregulation of DCs is implicated in autoimmunity, but the molecules that regulate protect against autoimmunity have remained unknown. In this study, we show mice lacking protein tyrosine phosphatase Shp1 specifically develop splenomegaly associated with more CD11c(+) DCs. Splenic from mutant showed upregulation CD86 CCR7 expression LPS-induced production proinflammatory cytokines. The manifested splenic...
<b>Background and study aims:</b> The aim of the current was to assess detection rate right adrenal gland diagnostic ability endoscopic ultrasound (EUS) fine-needle aspiration (FNA) for diagnosis metastasis in potentially resectable lung cancer. <b>Patients methods: </b>This retrospective cohort included a consecutive series 150 patients undergoing EUS/EUS – FNA staging by EUS accuracies computed tomography (CT), positron emission tomography-CT (PET-CT), were evaluated. <b>Results:</b>...
To investigate the expression of activin A and its receptors in rheumatoid arthritis (RA) synovial tissues, to determine effect on cultured fibroblast-like synoviocytes (FLS).The localization type II receptor (ARII) tissues RA patients was analyzed by immunohistochemistry. The human FLS examined reverse transcriptase-polymerase chain reaction Western blotting. Enzyme-linked immunosorbent assay used measure culture supernatants. cell growth determined (3)H-thymidine incorporation MTT...
Abstract Objective This study aimed to assess the influence of modifying dose enfortumab vedotin (EV) monotherapy in patients with advanced urothelial carcinoma (UC). Methods We retrospectively evaluated consecutive metastatic UC who had received EV following platinum-based chemotherapy and immune checkpoint inhibitor therapy at our institution between December 2021 June 2024. The relative intensity (RDI), reason for adjustments, overall survival (OS) were analyzed. Results Overall, 49...
Sulfite, a common air pollutant, is toxic for humans, causing hypersensitivity or chronic airway diseases. We previously reported that sulfite actively produced from neutrophils by stimulation with bacterial endotoxin, lipopolysaccharide (LPS). also found the serum concentration increased in rat model of sepsis induced systemic injection LPS. However, information on metabolism human inflammatory conditions limited. In current study, was determined 25 patients acute pneumonia. Serum pneumonia...
Abstract Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) is a transmembrane that binds the phosphatases SHP-1 and SHP-2 through its cytoplasmic region expressed on surface of CD11c+ dendritic cells (DCs) macrophages. In this study, we show mice express mutant form SHPS-1 lacking most are resistant to experimental autoimmune encephalomyelitis (EAE) in response immunization with peptide derived from myelin oligodendrocyte glycoprotein (MOG (35–55)). The...
Conventional dendritic cells (cDCs) are required for peripheral T cell homeostasis in lymphoid organs, but the molecular mechanism underlying this requirement has remained unclear. We here show that cell–specific CD47-deficient ( Cd47 ΔT ) mice have a markedly reduced number of tissues. Direct interaction with cDCs resulted activation latter cells, which turn induced necroptosis former cells. The deficiency and death expression its receptor signal regulatory protein α on cDCs. development...
Although stimulation of freshly isolated murine spleen cells with anti-CD3 mAb or Con A failed to generate IL-12 production, the same cell preparations depleted B produced IL-12. Addition normal inhibited production in a number-dependent manner. was dependent on presence CD4+, but not CD8+, T cells, and by addition anti-CD40 ligand (CD40L) mAb. Anti-CD3 induced CD40L expression only CD4+ which cells. also interactions between CD40L-transfected Chinese hamster ovary splenocytes APC,...
Signals through the B cell antigen receptor lead to a variety of cellular events such as activation, anergy, and apoptosis. cells select these outcomes establish maintain self-tolerance, mount adequate antibody responses. However, it is not fully understood how one same signal causes different consequences. In present study, we have studied effect activation signals on outcome responses ligation. Two distinct growth-promoting were used activate cells. Ligation either RP105, newly discovered...
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme involved in maintaining cholesterol homeostasis. In familial LCAT deficiency (FLD), abnormal lipid deposition causes renal injury and nephrotic syndrome, frequently progressing to ESRD. Here, we describe a 63-year-old Japanese woman with no family history of disease who presented syndrome. The laboratory data revealed extremely low level serum HDL undetectable activity. Renal biopsy showed glomerular prominent accumulation foam cells,...
In RA, response to TNF blockers may be associated with a profile of cytokine production unique each patient. This study sought predict the biologic agents by examining pro-inflammatory synthesis in stimulated whole blood cultures (WBCs).We measured concentration TNF-α, IL-1β and IL-6 supernatants lipopolysaccharide (LPS)-stimulated WBCs obtained from RA patients (n = 41) before anti-TNF therapy (infliximab, 13; etanercept, 26; adalimumab, 2) healthy controls 12). At 24 weeks after biologics,...
Acute kidney injury (AKI) is a common but complex condition that associated with increased morbidity and mortality. In the present study, we examined whether urinary activin A, member of TGF-beta superfamily, in mice ischemia-reperfusion humans AKI, as well its potential biomarker for AKI. Expression A was markedly ischemic mouse kidneys. situ hybridization demonstrated mRNA expressed tubular cells kidneys not normal Immunoreactive which absent kidneys, detected cytoplasm proximal Activin...
Significance Homeostasis of Pdpn + fibroblastic reticular cells (FRCs) is thought to be regulated by hematopoietic cells. However, the cellular and molecular mechanisms such homeostasis have been poorly understood, especially under steady-state condition in adults. We show that dendritic cells, particularly CD4 conventional (cDCs), are crucial for FRCs adult spleen condition. The production TNF receptor ligands cDCs regulates FRCs, with SIRPα CD47 likely being indispensable TNFR cDCs....
HIV-associated nephropathy (HIVAN) is characterized by a collapsed glomerular capillary tuft with hyperplasia and hypertrophy of podocytes. Recently generated were conditional transgenic mice (podocin/Vpr) that express one the HIV-1 accessory genes, vpr, selectively in podocytes using podocin promoter Tet-on system. These developed renal injury similar to HIVAN when treated doxycycline for 8 12 wk. This study demonstrated nephron reduction heminephrectomy markedly enhanced phenotypic changes...