A5032691621- Complement system in diseases
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mechanical Circulatory Support Devices
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diet, Metabolism, and Disease
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease and Transplantation
- Retinal Diseases and Treatments
- Hemophilia Treatment and Research
- Glaucoma and retinal disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Retinal Imaging and Analysis
- Cardiac Valve Diseases and Treatments
- Diet and metabolism studies
- Cardiac Structural Anomalies and Repair
- Mast cells and histamine
- Environmental Policies and Emissions
Hokkaido University
1992-2025
Nara Medical University
2015-2024
Nara Medical University Hospital
2012-2022
Kyoto University
2021
National Institute of Biomedical Innovation, Health and Nutrition
2021
The University of Tokyo
2021
Gunma University Hospital
1992-2020
Nara Prefectural University
2017
Kaketsuken (Japan)
2013
Gunma University
2003
Abstract Overeating and arrhythmic feeding promote obesity diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar d -allulose ( -psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake promotes glucose tolerance in healthy obese-diabetic animal models. Subchronic administered at light period (LP) onset...
The secretion of glucagon-like peptide-1 (GLP-1) is promoted by various nutrients, and glucose fructose stimulate GLP-1 via intracellular metabolism. D-Allulose (allulose), a non-metabolizable epimer D-fructose, also effective in stimulating secretion, although its underlying mechanism remains unclear. We previously observed intestinal distension after the oral administration allulose, accompanied increased rats, possibly because low or slow absorbability allulose. In this study, we sought...
Abstract: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by increased platelet clearance because of antiplatelet antibodies. It was recently reported that the balance T helper 1 (Th1) and 2 (Th2) subsets has been implicated in regulation many responses. In this study, intracellular interleukin‐4 interferon‐ γ production CD4 + T‐lymphocytes activated phorbol 12‐myristate 13‐acetate ionomycin assessed via flow cytometry order to determine clinical...
Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy (TMA). Studies report that the majority TTP patients present with deficiency ADAMTS13 activity. In database TMA in Japan identified between 1998 and 2008, 186 first onset acquired idiopathic (ai) ADAMTS13-deficient (ADAMTS13 activity <5%) were diagnosed. The median age this group was 54 years, 54.8% female, 75.8% had renal involvement, 79.0% neurologic symptoms, 97.8% detectable inhibitors to Younger less...
Various cardiovascular diseases cause acquired von Willebrand syndrome (AVWS), which is characterized by a decrease in high-molecular-weight (large) factor (VWF) multimers. Mitral regurgitation (MR) has been reported as of AVWS. However, much remains unclear about AVWS associated with MR.
Patients with severe COVID-19 often experience complications including coagulopathy and fatal thrombosis. pneumonia sometimes leads to acute respiratory distress syndrome, requiring extracorporeal membrane oxygenation (ECMO), during which thrombosis bleeding are major causes of death. Anticoagulation such as heparin is essential for patients on ECMO; however, might be caused by not only heparin, but also acquired von Willebrand syndrome (AVWS). To date, no study has examined ECMO-related...
Patients with severe aortic stenosis (AS) may have bleeding episodes due to the loss of high-molecular-weight (HMW) von Willebrand factor multimers (VWFMs). The absence HMW-VWFMs and tendency are usually corrected after valve replacement (AVR). To investigate process VWFM recovery symptoms in patients AS, we analyzed changes VWF antigen (VWF:Ag), ADAMTS13 activity (ADAMTS13:AC), platelet thrombus formation under high shear stress conditions.Nine AS undergoing AVR were analyzed.Evident...
Oxaliplatin-based chemotherapy is widely used to treat advanced colorectal cancer (CRC). Sinusoidal obstruction syndrome (SOS) due oxaliplatin a serious type of chemotherapy-associated liver injury (CALI) in CRC patients. SOS thought be caused by the sinusoidal endothelial cell damage, which results release unusually-large von Willebrand factor multimers (UL-VWFMs) from cells. To investigate pathophysiology CALI after oxaliplatin-based chemotherapy, we analyzed plasma concentration (VWF) and...
Background Thrombotic thrombocytopenic purpura ( TTP ) is characterized by deficient ADAMTS 13 activity. Treatment involves plasma exchange PE ). Both fresh‐frozen FFP and cryosupernatant CSP are used, but it remains to be determined which more effective. Study Design Methods To analyze the interaction between von Willebrand factor VWF 13, we used large‐pore isoelectric focusing IEF analysis followed detection with anti‐ ADAMT S13 monoclonal antibody. , cryoprecipitate CP ), purified were...
Background: Severe aortic stenosis (AS) causes acquired von Willebrand syndrome (AVWS) by the excessive shear-stress-dependent cleavage of high molecular weight multimers factor (VWF).While current standard diagnostic method is so-called VWF multimer analysis that western blotting under non-reducing conditions, it remains unclear whether a ratio ristocetin co-factor activity (VWF:RCo) to antigen levels (VWF:Ag) <0.7, which can be measured with an automated coagulation analyzer in clinical...
We investigated the association between von Willebrand factor (VWF) and exudative age-related macular degeneration (AMD) in 114 Japanese patients. Intravitreal injection of vascular endothelial growth (VEGF) inhibitor is most effective therapy for AMD. Therefore, we analyzed changes VWF antigen (VWF:Ag) multimers (VWFMs) after intravitreal aflibercept, an anti-VEGF antagonist. The relationship polymorphisms complement H (p.Y402H p.I62V) AMD was previously reported. In our patients, p.I62V,...
Abstract Influenza infections often cause pneumonia, but there is limited information on thrombotic microangiopathy ( TMA ) in these circumstances. We report the case of an 11‐year‐old boy who developed during acute phase H1N1 influenza. Plasma von Willebrand factor VWF was elevated, whereas a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 ADAMTS 13) activity mildly reduced absence 13‐neutralizing autoantibody, resulting low ratio to . The patient treated...
A 67-year-old woman with recurrent gastrointestinal bleeding and aortic valve stenosis presented spurting from angiodysplasia of the upper jejunum. As electrophoresis revealed decreased levels high-molecular-weight (HMW) von Willebrand factor (VWF) multimers, she was diagnosed Heyde's syndrome. After replacement, her HMW VWF quickly recovered to normal, ceased. However, capsule endoscopy still six months later. This case shows that minute analyses multimers enable diagnosis confirmation...
Key Clinical Message We report a 14‐year‐old girl, who developed shigatoxin‐producing E. coli ( STEC )‐ HUS complicated by encephalopathy. She was successfully treated with hemodiafiltration, high‐dose methylprednisolone pulse therapy, and soluble recombinant thrombomodulin under plasma exchange. von Willebrand factor multimers analysis provides potential insights into how the administered therapies might facilitate successful treatment of ‐ .
Rationale: Plasma exchange is the principal treatment for acquired thrombotic thrombocytopenic purpura (TTP) but invasive and may have adverse effects. Reports of immunoglobulin therapy TTP without plasma are rare. Patient concerns: A 14-year-old girl was admitted because hemolytic anemia thrombocytopenia. Diagnosis: Acquired diagnosed based on low ADAMTS13 (a disintegrin-like metalloproteinase with thrombospondin type 1 motif, 13) activity a high inhibitor level. Interventions & Outcomes:...