A5042551306- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- DNA Repair Mechanisms
- Retinoids in leukemia and cellular processes
- Eosinophilic Disorders and Syndromes
- Hematological disorders and diagnostics
- Blood groups and transfusion
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- CNS Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
Gunma University of Health and Welfare
2019-2025
Gunma University
2015-2024
Bristol-Myers Squibb (Japan)
2024
Kansai University
2024
Gunma University Hospital
1992-2022
Tohoku University
2017
MRC Laboratory of Molecular Biology
2014
Gunma Prefectural College of Health Sciences
2014
RMIT University
2008-2013
Mitsubishi Research Institute (Japan)
2012
SUMMARY It has been suggested that vitamin B12 (vit.B12) plays an important role in immune system regulation, but the details are still obscure. In order to examine action of vit.B12 on cells human system, lymphocyte subpopulations and NK cell activity were evaluated 11 patients with deficiency anaemia 13 control subjects. Decreases number lymphocytes CD8+ proportion CD4+ cells, abnormally high CD4/CD8 ratio, suppressed noted compared all eight subjects, these parameters before after...
Abstract BACKGROUND. Although studies comparing conventional imaging modalities with 18 F‐fluorodeoxyglucose positron emission tomography ( F‐FDG‐PET) for the detection of lymphoma and although relations between F‐FDG‐PET histologic types were reported previously, most not systematic involved relatively small numbers patients. METHODS. Two hundred fifty‐five patients had their disease staged using F‐FDG‐PET, 191 those also assessed gallium‐67 scintigraphy 67 Ga). Disease sites identified on...
The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics outcomes of multiple myeloma (MM) involving central nervous system (CNS). Univariate multivariate analyses were performed identify prognostic factors for survival. median time diagnosis was 3 years. Thirty‐eight (22%) diagnosed involvement at initial 134 (78%) relapse/progression. Upon MM, 97% received therapy...
Abstract: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by increased platelet clearance because of antiplatelet antibodies. It was recently reported that the balance T helper 1 (Th1) and 2 (Th2) subsets has been implicated in regulation many responses. In this study, intracellular interleukin‐4 interferon‐ γ production CD4 + T‐lymphocytes activated phorbol 12‐myristate 13‐acetate ionomycin assessed via flow cytometry order to determine clinical...
OGG1 protein has an ability to suppress mutagenesis induced by 8-hydroxyguanine (8OHG), oxidatively damaged promutagenic base. Here, the mutation suppressive was compared between two common polymorphic proteins, OGG1-Ser326 and OGG1-Cys326, using a supF forward assay employing 8OHG-containing plasmid. Polymorphic proteins were exogenously expressed adenoviral transduction in H1299 human lung cancer cells, which endogenous undetectable western blot analysis. Mutations 8OHG more efficiently...
Summary Extramedullary myeloma ( EMM ) occurs when develops outside the bone marrow; it often after chemotherapy and is associated with acquisition of chemo‐resistance a fatal course. The mechanisms underlying extramedullary spread have not yet been fully elucidated. MALAT 1 highly abundantly ubiquitously expressed long non‐coding RNA that plays important roles in cancer metastasis. aims this study were to clarify association elucidate mechanism formation under chemotherapeutic pressure....
Background. It was assessed whether addition of vincristine (VCR) to remission induction therapy would increase the complete (CR) rate, and, secondarily, 12 courses maintenance—intensification produce longer survival than 4 in adult acute myeloid leukemia (AML). Methods. A randomized comparison individualized conducted between daunorubicin, behenoyl cytarabine, 6-mercaptopurine, and prednisolone with or without VCR. After 3 intensive consolidation therapy, given every 6 weeks. Results. Of...
PURPOSE We analyzed complete remission (CR), disease-free survival (DFS), and event-free (EFS) rates in two groups of patients treated with either N4-behenoyl-1-beta-D-arabinosylcytosine (BHAC) or cytarabine, DFS without ubenimex, a biologic response modifier. PATIENTS AND METHODS Newly diagnosed acute myeloid leukemia (AML) were randomized to receive BHAC cytarabine as remission-induction combination chemotherapy courses consolidation therapy. After maintenance/intensification therapy, CR...
Novel agents such as thalidomide, lenalidomide and bortezomib have dramatically changed the treatment paradigm of multiple myeloma (MM). However, it is not clear whether these improve prognosis elderly patients who undergone autologous stem cell transplantation (auto-SCT). We retrospectively analyzed outcome 318 newly diagnosed aged 65-70 years were treated between January 1, 2004, December 31, 2009. As initial therapy, 192 with conventional chemotherapy, 88 novel agent-containing regimens,...
T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated impact of Th1/Th2 cytokine receptor functional polymorphisms on both susceptibility to, severity of, cITP. analysed IFN-γ + 874 T/A, IFN-γR -611G/A, IL-4 -590C/T, IL-4Rα Q576R 126 cITP patients (male/female: 34/92; median age: 47.7 years) 202 healthy control donors. Genotyping was determined by PCR direct sequencing. The ratio detected peripheral...
To investigate the clinical significance of granulocytic sarcoma (GS) in adults with acute myeloid leukemia (AML), 434 consecutive patients AML were analyzed retrospectively. Forty-five (10.4%) GS at diagnosis younger (P < 0.001), presented higher white blood cell counts = 0.03) and more likely to conform French-American-British M4 0.001) M5 0.045) classifications than those without GS. In contrast, no significant difference frequency cytogenetic abnormalities was found between non-GS...
Chemokine receptors (CRs) and the prostaglandin D2 receptor, CRTH2, have been used as surrogate markers for cytoplasmic Th1 Th2 cytokines. The presence of regulatory T (Treg) Th17 cells may affect analysis such markers, they share several CRs with cells. This study aimed to determine optimal under physiological conditions.Surface CD4+ peripheral lymphocytes were analyzed in healthy volunteers by flow cytometry. Th1, Th2, Th17, Treg identified IFN-γ+ , IL-4+ IL-13+ IL-17+ CD25+ FoxP3+...
Summary. The findings of morphologically dysplastic features in haemopoietic cells de novo acute myeloid leukaemia (AML) has been named AML with trilineage myelodysplasia (AML/TMDS). We analysed the clinical data, karyotypes, and treatment outcomes 230 patients treated Japan Adult Leukaemia Study Group AML‐87 protocol. 40 (17%) had AML/TMDS. Platelet count was significantly higher ( F =0·006) bone marrow blasts were fewer P =0·01) AML/TMDS group than without TMDS. Abnormal karyotype shown...
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the production of autoreactive antibodies against platelet antigens. Although dysfunction multiple aspects cellular immunity considered to be important in pathogenesis ITP, it has not been clarified which cell types play a principal role.We enrolled 46 untreated patients with chronic ITP and 47 healthy adult volunteers, investigated flow cytometry percentage absolute number cells their peripheral blood that participate...
IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP frequency of single-nucleotide polymorphism rs763780 (7488T/C), which causes His-to-Arg substitution at amino acid 161.We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with 188 healthy controls 78/110; 38). Genotyping was determined by polymerase chain reaction-restriction fragment length (PCR-RFLP) technique.Compared...
Novel agents inducing deeper responses have improved the prognosis of patients with multiple myeloma (MM). To assess minimal residual disease (MRD) and stratify achieving complete response (CR), advanced technologies such as EuroFlow next-generation flow cytometry (NGF) sequencing (NGS) are increasingly utilized. This prospective study evaluated in newly diagnosed MM undergoing autologous stem cell transplantation (ASCT) followed by lenalidomide maintenance therapy across Japanese medical...