A5057829791- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Antifungal resistance and susceptibility
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Retinoids in leukemia and cellular processes
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Cancer Treatment and Pharmacology
- Platelet Disorders and Treatments
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Brain Metastases and Treatment
- Spondyloarthritis Studies and Treatments
Gunma Children's Medical Center
2010-2017
Hyogo Prefectural Cancer Center
2012
Gunma University Hospital
2010
Gunma University
1997-2009
Gunma Saiseikai Maebashi Hospital
2003-2007
Summary There have been conflicting reports over the JAK2‐V617F mutation status of platelets in chronic myeloproliferative diseases (CMPDs). The aim this study was to analyse status, not only granulocytes but also platelets. analysed both and 115 patients with CMPDs using direct sequencing. detected from 71 those patients, all whom had platelet expression. remaining 44 showed negative expression on granulocytes, positive nine 33 essential thrombocythaemia (ET) one eight polycythaemia vera...
Atypical lymphoplasmacytic immunoblastic proliferation (ALPIB) is a rare lymphoproliferative disorder (LPD) associated with autoimmune disease (AID). To further clarify the clinicopathologic, immunohistological, and genotypic findings of ALPIB in lymph nodes well-documented AIDs, 9 cases are presented. These patients consisted 4 systemic lupus erythematosus, 3 rheumatoid arthritis, one case each Sjögren's syndrome dermatomyositis. All were females aged from 25 to 71 years median age 49...
A 59-year-old man was diagnosed to have idiopathic myelofibrosis (IMF) in November 2001. In April 2004, massive ascites and esophageal varices were found. IMF considered be the cause of portal hypertension (ascites varices). Since tend intractable with diuretic drugs, a transjugular intrahepatic portosystemic shunt (TIPS) inserted May 2004. Before TIPS, his waist measured 98 cm. On day 74 after 68 cm as result administration drugs alone. He eventually died due hepatic failure on 168 TIPS....
Summary The chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of in FL, and clarified correlations between cytogenetic features clinical outcome. Cytogenetic analysis was performed using standard methods Giemsa‐banding at diagnosis for 201 FL patients admitted to our hospitals 2001 2013. identified were: t(14;18)(q32;q21) (59·2%), +X (17·9%), del(6)(q)/‐6 (16·9%), +7 (14·4%), abnormality 1q12‐21/1q (12·9%),...
We report 10 patients with T-cell large granular lymphocyte (LGL) leukaemia: four had CD16+ CD56- LGL lymphocytes (typical for leukaemia), and six CD56+ CD16(dim/-) (atypical). Among the CD(dim/-) patients, were CD4+ CD8- in one patient, CD4/CD8 double positive (DP) three, CD4- CD8+ two. The CD8dim DP cells expressed a CD8alphaalpha homodimer. receptor (TCR) Vbeta complementarity-determining region 3 (CDR3) size distribution analysis direct sequencing identified at least 1 in-frame clonal...
Immunologic abnormalities have been described in patients with Hodgkin lymphoma, including autoimmune hemolytic anemia and immune thrombocytopenic purpura. The concurrent diagnoses of lymphoma acquired aplastic anemia, however, is extremely rare. We report a 56-year-old Japanese female patient severe increased large granular lymphocytes prior to the recurrence lymphoma. After being remission for 10 years from she developed progressive pancytopenia. (expressed CD3+ CD8+ TCRαβ+) had polyclonal...
Using our recently developed human androgen receptor (HUMARA) gene-based chimerism assay, long-term was investigated in female patients who underwent hematopoietic stem cell transplantation (HCT) with cells from male donors. After restriction digestion of samples, we detected a small number female-derived within large population male-derived cells, sensitivity 0.1% to 0.05%. Chimerism examined four myeloid malignancies: two acute leukemia (AML) myelodysplastic syndrome (MDS), and one patient...
We describe a patient with biphenotypic acute leukemia (BAL) T-lymphoid lineage and myeloid differentiation [BAL (T/M)]. Cytogenetic analysis revealed complex chromosomal abnormalities, including der(2)t(2 ; 11)(p21 q23). Neither cells nor T-cell receptor gene rearrangements were detected in the bone marrow samples after four courses of high dose cytosine arabinoside regimen. However, q23) anomaly persisted most metaphases. Fluorescence situ hybridization (FISH) probe for MLL did not detect...