A5056034835- HIV Research and Treatment
- Pancreatitis Pathology and Treatment
- HIV/AIDS drug development and treatment
- Pancreatic and Hepatic Oncology Research
- Salivary Gland Disorders and Functions
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Vascular anomalies and interventions
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- HIV/AIDS Research and Interventions
- Chronic Lymphocytic Leukemia Research
- Cell death mechanisms and regulation
- Vehicle emissions and performance
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Protein Hydrolysis and Bioactive Peptides
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Salivary Gland Tumors Diagnosis and Treatment
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Cardiac Ischemia and Reperfusion
- Aquaculture Nutrition and Growth
- Insect and Pesticide Research
Kariya Toyota General Hospital
2015-2024
Himeji Medical Center
2023
Hyogo Brain and Heart Center
2021
Gunma University
2000-2019
Kagoshima University
2014-2016
Juntendo University
2015-2016
Yokohama City University
2015
National Center For Child Health and Development
2013
Kanagawa Prefectural Institute of Public Health
1994-2012
Hachinohe National College of Technology
2008-2012
Nicotinoids and neonicotinoids are characterized by the presence of 3-pyridylmethylamine moiety in their structure. In former, amino nitrogen atom is ionized, while latter corresponding not ionized but bears a partial positive charge. Both types insecticides interact with nicotinic acetylcholine receptor (nAChR) insect origin. The poor interaction vertebrate nAChR was shown its binding affinity to from Torpedo electric organ rat brain activation expressed Xenopus oocytes. full charge...
[3H]α-ブンガロトキシン, [3H] ニコチンをプローブとしニコチン性アセチルコリン受容体 (nAChR) の認識部位へのニコチノイド, ネオニコチノイド, 関連化合物の結合性をみた結果, 昆虫nAChRでは3-ピリジルメチルアミノ部分をもつこと, 脊椎動物nAChRではイオン化度の高いことが必要であった. フェンサイクリジンを用い Torpedo のnAChRのイオンチャンネル開口への効果をみた結果, アゴニスト作用を呈するのに3-ピリジルメチルアミノ部分があるほうがよいが, イオン化度の高いことが必要であった. ニコチノイドのアミノ窒素原子とネオニコチノイドの構造上対応する窒素原子の15N NMRを測定したところ, 後者は前者に比べはるかに低磁場にあり, 窒素原子上の非共有電子対が電子吸引性基により非局在化, すなわち部分正荷電を帯びていることを示し, これが昆虫のnAChRとの相互作用には十分だが, 脊椎動物のそれとは不十分であるといえる. これによってニコチンは温血動物への毒性が高く, 殺虫活性が限られているのに対し, イミダクロプリドはその反対の特性を示すことが説明できる.
Summary Extramedullary myeloma ( EMM ) occurs when develops outside the bone marrow; it often after chemotherapy and is associated with acquisition of chemo‐resistance a fatal course. The mechanisms underlying extramedullary spread have not yet been fully elucidated. MALAT 1 highly abundantly ubiquitously expressed long non‐coding RNA that plays important roles in cancer metastasis. aims this study were to clarify association elucidate mechanism formation under chemotherapeutic pressure....
The common cytokine receptor γ chain (γc) is an essential component for IL-2, IL-4, IL-7, IL-9 and IL-15, thereby γc-deficient mice exhibit impaired T cell B development. Janus family tyrosine kinase 3 (Jak3) known to be associated with γc, the reported phenotypes of (γc–) Jak3-deficient (Jak3–) are similar, indicating that Jak3 transducer γc-dependent signals. Nevertheless, certain differences have been suggested related range actions γc Jak3. To clarify whether cytokines can partially...
Rice paddy soil has been shown to have strong denitrifying activity. However, the microbial populations responsible for denitrification not well characterized. In this study, we employed Stable Isotope Probing (SIP) study succinate-assimilating denitrifiers in microcosms amended with nitrate and (13)C-succinate. Microbial represented (12)C- (13)C-DNA fractions were different based on denaturing gradient gel electrophoresis (DGGE) of PCR-amplified 16S rRNA gene fragment. A nearly full-length...
Background: Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chronic inflammation is regulated by macrophage polarity, often referred as proinflammatory (M1) or anti-inflammatory (M2) macrophages. Although opioids such morphine are known alter milieu incisional wounds through interactions with immunocytes, macrophage-mediated effects on...
Background In 2009, a pandemic (pdm) influenza A(H1N1) virus infection quickly circulated globally resulting in about 18,000 deaths around the world. Japan, infected patients accounted for 16% of total population. The possibility human-to-human transmission highly pathogenic novel viruses is becoming fear human health and society. Methodology To address clinical need rapid diagnosis, we have developed new method, "RT-SmartAmp assay", to rapidly detect 2009 from patient swab samples....
The wound healing process following acute inflammation after surgery is impaired in diabetes. Altered macrophage functions are linked to delayed tissue repair and pain development Although peroxisome proliferator-activated receptor (PPAR)-γ agonists used treat diabetes, their postoperative analgesic effects diabetes have not been evaluated.The PPARγ agonist rosiglitazone (rosi) was injected at the incision site of diabetic (db/db) mice with resolvin (Rv) D1, a lipid mediator involved...
Five healthy young male subjects were given meals containing different levels of dietary fiber (DF) for one week each, and the effects on fecal output, gastrointestinal transit time, frequency evacuation, apparent excretion rate in feces studied. The experiments conducted twice by varying DF levels. following results obtained. 1) With an increase intake DF, increased significantly both wet weight volume. specific gravity did not show any clear-cut relation with level DF. 2) time tended to...
Comparative histologic examination and measurement of amylase values in pancreas parotid gland were made on thirteen rats the control group eight with experimentally produced acute pancreatitis. Histologically, grade findings pancreatitis well correlated to that atrophic changes gland. With respect values, apparently showed lower both than those group. Lowering rate value was remarkable pancreas, while it moderate It concluded experimental production also caused hypofunction
Aggregatibactor actinomycetemcomitans colonizes human periodontal lesions and is implicated in both aggressive periodontitis chronic periodontitis. Clinical isolated colonies of A. were rough type. The type has a remarkable ability to adhere tenaciously solid surfaces colonize firmly. Rough change into smooth during the course repeated inoculation biofilm-forming activity ceases. Adherence by mediated tight-adherence (tad) gene locus, which includes flp, rcpA rcpB. In this study, we...
<h3>Background and Objectives</h3> Anesthesia with peripheral nerve block (PNB) improves the early recovery profile of patients undergoing surgery, including control postoperative pain, opioid consumption, length hospital stay. However, influence PNB on wound inflammation repair process has not been fully investigated. Therefore, we evaluated effects local incised tissue in acute phase pain development. <h3>Methods</h3> Sciatic 0.5% ropivacaine was performed before plantar incision mice....
We recently demonstrated that calcitonin gene-related peptide (CGRP) released from sensory neurons reduces spinal cord injury (SCI) by inhibiting neutrophil activation through an increase in the endothelial production of prostacyclin (PGI<sub>2</sub>). Carperitide, a synthetic α-human atrial natriuretic (ANP), ischemia/reperfusion (I/R)-induced tissue injury. However, its precise therapeutic mechanism(s) remains to be elucidated. In present study, we examined whether ANP I/R-induced...
Laboratory diagnostic tests for pancreatic diseases were carried out by examination of samples parotid saliva in 22 patients, whom 9 with disorders and 13 other organs or systems. Trend analyses the data thereby obtained revealed approximate borderline values (lower higher non-pancreatic disorders) rate salivary secretion, its maximum bicarbonate concentration amylase secretion to be 0.6ml per minute, 20 mEq/L, 1, 000 units kg body weight, respectively. The results present study emphasize...
Degenerative changes of the parotid gland and a marked decrease maximum bicarbonate concentration in saliva were found dogs with acute experimental pancreatitis.
In rats of recovery from experimentally produced pancreatitis it was found that histologic findings and amylase values the parotid gland changed parallel to severity pancreatic changes there no significant correlation between pancreas serum during repairing period pancreatitis.