A5085472324- Spaceflight effects on biology
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Autism Spectrum Disorder Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Skin Protection and Aging
- CRISPR and Genetic Engineering
- Amino Acid Enzymes and Metabolism
- Genomic variations and chromosomal abnormalities
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Chronic Lymphocytic Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Protein Hydrolysis and Bioactive Peptides
- Cell death mechanisms and regulation
- Sports Performance and Training
- Animal Nutrition and Physiology
- Neuroendocrine regulation and behavior
- Genetics, Aging, and Longevity in Model Organisms
Kobe University
2021-2025
Chiba University
2002-2023
RIKEN Center for Brain Science
2016-2023
Tohoku Medical and Pharmaceutical University
2020-2023
Tohoku University
1992-2023
Tohoku Medical and Pharmaceutical University Hospital
2021-2022
IPB University
2017-2021
Tohoku Medical and Pharmaceutical University Wakabayashi Hospital
2012-2018
Hiroshima University
2012-2016
Johns Hopkins Medicine
2010-2015
Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia mood disorders. Recent studies have shown that DISC1 has important functions brain development adult function. We described earlier a transgenic mouse model of inducible expression mutant human (hDISC1) acts dominant-negative manner to induce marked neurobehavioral abnormalities. To gain insight into roles at various stages neurodevelopment,...
Genetic mutations contribute to the etiology of autism spectrum disorder (ASD), a common, heterogeneous neurodevelopmental characterized by impairments in social interaction, communication, and repetitive restricted patterns behavior. Since neuroligin3 (NLGN3), cell adhesion molecule at neuronal synapse, was first identified as risk gene for ASD, several additional variants NLGN3 NLGN4 were found ASD patients. Moreover, synaptopathies are now known cause neuropsychiatric disorders including...
Abstract Patients with psychiatric disorders such as autism spectrum disorder (ASD) showed various and heterogeneous clinical symptoms even share the same mutation. Furthermore, comorbidity of makes it more complicated, despite manifestations ASD that have been established. In genetic genomic aspects, has categorized a due to studies investigating concordant discordant monozygotic twins. These past also identified chromosome mutations deletion duplication larger than 1 kb in patients ASD....
<title>Abstract</title> Autism spectrum disorder (ASD) is a neurodevelopmental with diverse genetic and environmental origins, yet whether these factors converge on common molecular pathways remains unclear. Here we identify dysregulation of the Notch signaling pathway as shared mechanism in both hereditary non-hereditary ASD models. Aberrant HDAC3-mediated epigenetic regulation during embryonic forebrain development disrupts specification caudal ganglionic eminence (CGE) progenitors into...
Signals through the B cell antigen receptor lead to a variety of cellular events such as activation, anergy, and apoptosis. cells select these outcomes establish maintain self-tolerance, mount adequate antibody responses. However, it is not fully understood how one same signal causes different consequences. In present study, we have studied effect activation signals on outcome responses ligation. Two distinct growth-promoting were used activate cells. Ligation either RP105, newly discovered...
Specific binding of antigens to the surface immunoglobulln M (slgM) triggers B cells with several biochemical events Involved in receptor-mediated signal transmission for proliferation and differentiation into antibody-producing cells. Recent studies Digitonin lysis method identified slgM-assoclated component, IgM-α (B34)/lg-β, as possible candidate transducer molecule(s) In transmission. The 34 kdprotein (B34 or IgM-α) this component Is suggested be encoded by cell-specific mb-1 gene. We...
Most Th2 clones, when activated, produce IL-4 and express CD40 ligand (CD40L) on their cell surface. Therefore, they can induce growth differentiation of B cells by cognate help. In contrast, activated Th1 which IFN-gamma both CD40L Fas (FasL) surface, often apoptotic death. To understand the mechanism in presence FasL-positive cells, we stimulated with IL-4, anti-IgM and/or anti-CD40 anti-Fas. We report here that addition anti-Fas strongly inhibited anti-CD40-induced proliferation without...
Abstract Stem cells have the remarkable ability to self-renew and generate multiple cell types. Nucleostemin is one of proteins that are enriched in many types stem cells. Targeted deletion nucleostemin mouse results developmental arrest at implantation stage, indicating crucial for early embryogenesis. However, molecular basis function embryos remains largely unknown, role tissue has not been examined by gene targeting analyses due embryonic lethality null animals. To address these...
The serotonergic pathway has been implicated in the pathogenesis of impulsivity, and sensitivity to aversive outcomes may be linked serotonin (5-HT) levels. Polymorphisms gene that encodes transporter (5-HTT), which have differential effects on level transmission, display alternate responses stimuli. However, recent studies shown 5-HT does not affect motor function, suggests functioning serotonin-transporter-linked polymorphic region (5-HTTLPR) directly behavioral regulatory process itself,...
Primary adrenal lymphoma (PAL) is an extremely rare subtype of extranodal non-Hodgkin's lymphoma. Some researchers have reported some the characteristics PAL and its association with poor prognosis; however, clinicopathological features remain to be elucidated.From 2008 2011 we experienced seven cases in our institutions. We retrospectively analyzed clinical pathological these patients.The patients ranged age from 50 85 years, a median 71 years. The overall male:female ratio was 6:1. All...
Nilotinib is a second-generation tyrosine kinase inhibitor that exhibits significant efficacy as first- or second-line treatment in patients with chronic myeloid leukemia (CML). We conducted multicenter Phase II Clinical Trial to evaluate the safety and of nilotinib among Japanese imatinib-resistant -intolerant CML-chronic phase (CP) accelerated (AP).We analyzed 49 (33 16 imatinib-intolerant) treated 400 mg twice daily. The major molecular response (MMR) rate was 47.8% at 12 months 35 who...
A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated characteristics of recently identified memory-enhancing compound, ISRIB for amelioration AD. potently attenuated amyloid β-induced neuronal cell death at concentrations 12.5-25 nM, but did inhibit β production in HEK293T line expressing precursor protein (APP). These results suggest that possesses unique property attenuating without affecting production.
Cross-linking of surface B cell Ag receptor (BCR) induces tyrosine phosphorylation BCR-associated components through a receptor-mediated signal transmission pathway. cell-specific mb-1 and B29 genes encode the alpha/beta complex in mature sIgM+ cells. Here, we studied involvement gene product, MB-1, BCR-related structure immature Affinity-purified anti-MB-1 antibody coprecipitated mu chain/20-kDa/15-kDa proteins together with monomer MB-1 Ig-alpha/Ig-beta heterodimer from digitonin lysates...
Triggering of the Ig receptor (IgR) induces activation in multiple intracellular signal transduction reactions including protein tyrosine phosphorylation, phospholipase C, increased inositoltriphosphate, diacylglycerol, Ca2+ mobilization, and kinase C. The IgR-complex, composed mu-chain, L chain, Ig-alpha (MB-1), Ig-beta (B29) proteins, is a functional unit both for expression IgR into cells, possibly by physical association with down-stream molecules. An important motif ((D or E)-X7-(D...
Delayed healing of skin wounds can be caused by wound instability, whereas appropriate massage or exercise prevents sclerosis and scar contracture. However, the mechanism which is related to mechanical stress has not been fully elucidated. The present study aimed identify whether stretching fibroblasts reduces their production extracellular matrix. We transferred into collagen-coated elastic silicone chambers, cultured them on a apparatus, used RT-PCR examine effects expression levels 17...
We hypothesised that the oxygen supply to fatigued muscles is improved after recovery with exercise caused by aerobic metabolism in slow twitch fibres during period. Ten males performed a 30 s maximum cycling (1st Exercise), followed 20 min rest interval (Interval Rest) which participants were either sitting (No Exercise) or low intensive (Active). Then they again underwent bout of (2nd Exercise). The total work 2nd Exercise was higher Active compared No (297 ± 14 vs 276 23 J · kg(-1), P <...