A5062650435- Rare-earth and actinide compounds
- Iron-based superconductors research
- Physics of Superconductivity and Magnetism
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Advanced Condensed Matter Physics
- Magnetic Properties of Alloys
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- High-pressure geophysics and materials
- RNA Research and Splicing
- Nuclear Physics and Applications
- Glycosylation and Glycoproteins Research
- Nuclear Materials and Properties
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Magnetic and transport properties of perovskites and related materials
- Radiation Detection and Scintillator Technologies
- Inorganic Chemistry and Materials
- Cancer-related Molecular Pathways
- Respiratory viral infections research
- Radioactive element chemistry and processing
Kindai University Hospital
2022-2024
Fujita Health University
2018-2022
Aichi Cancer Center
2013-2021
Fujita Health University Hospital
2019
Hirosaki University
2018
Ibaraki University
2009-2017
Nagoya University
2013-2017
Niigata University
2017
Kumamoto University
2006-2016
Hitachi (Japan)
2013-2016
Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health socioeconomic stability. Evidence of antibody-dependent enhancement (ADE) SARS-CoV infection in vitro non-human primates clouds prospects for safe vaccine. Using antibodies from SARS patients, we identified characterized B-cell peptide epitopes with disparate functions. In rhesus macaques, spike glycoprotein peptides S471-503, S604-625, S1164-1191 elicited...
We have performed elastic neutron-scattering experiments on the heavy-electron compound URu_2Si_2 for pressure P up to 2.8 GPa. found that antiferrmagnetic (100) Bragg reflection below T_m ~ 17.5 K is strongly enhanced by applying pressure. For < 1.1 GPa, staggered moment mu_o at 1.4 increases linearly from 0.017(3) mu_B 0.25(2) mu_B, while slightly a rate 1 K/GPa, roughly following transition temperature T_o determined macroscopic anomalies. also observed sharp phase P_c 1.5 above which...
From 29Si NMR study, we present evidence for spatially inhomogeneous development of antiferromagnetic (AF) ordering below T(o) = 17.5 K in URu2Si2. In the pressure range between 3.0 and 8.3 kbar, have observed lines arising from AF region as well previously line which correspond to nonmagnetic sample. The volume fraction is enhanced by applied pressure, whereas magnitude internal field at Si site remains constant (910 Oe) up kbar. region, ordered moment about an order larger than 0.03 mu(B)/U.
The involvement of chronic inflammation in cholangiocarcinoma (CCA) progression is well established. Cluster differentiation 47 (CD47) mutually expressed various cancers and serves as a protective signal for phagocytic elimination. CD47 signaling blockage recent treatment strategy; however, little known regarding CCA. Therefore, the potential use targeting CCA was focused. highly compared to hepatocellular carcinoma (HCC). Disturbance CD47-signal regulatory protein-α (SIRPα) interaction by...
We report inelastic neutron scattering experiments performed to investigate the low energy magnetic excitations on single crystals of heavy-fermion superconductor PrOs(4)Sb(12). The observed excitation clearly softens at a wave vector Q=(1,0,0), which is same as modulation field-induced antiferro-quadrupolar ordering, and its intensity Q=(1,0,0) smaller than that around zone center. This result directly evidences this excitonic behavior derived mainly from nonmagnetic quadrupolar...
A direct search has been made for supermassive relics (heavier than about ${10}^{12}$ GeV/${\mathit{c}}^{2}$) with a 2000-${\mathrm{m}}^{2}$ array of CR-39 track-etch detectors deployed underground 2.1 yr. The nonobservation penetrating tracks places new upper limit the velocity-dependent flux at 3.2\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}16}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$ ${\mathrm{s}}^{\mathrm{\ensuremath{-}}1}$...
Abstract BACKGROUND: The incidence of cholangiocarcinoma (CCA) is increasing globally. Currently, there no powerful marker for the diagnosis CCA, which has led to late and poor patient outcome. This study was designed establish a new monoclonal antibody (MoAb) detecting serum associated with CCA. METHODS: Pooled CCA tissue extracts were immunized germinal center nuclear protein (GANP)‐transgenic mice. antibody‐producing hybridomas prepared initially screened by using an indirect...
Abstract We have shown previously that a 52-kDa phosphoprotein (p52) co-precipitated with Ig receptor (IgR)-associated MB-1 protein was inducibly phosphorylated by the stimulation 12-O-tetradecanoyl-phorbol-13-acetate. By immunizing MB-1, we prepared mAb (19-14), which can immunoprecipitate p52 and associated kinase molecule. Immune complex assay 19-14 showed is novel molecule involved in IgR-mediated signal transduction. Here isolated cDNA clone (alpha 4) from murine bone marrow library...
URu2Si2 is one of the most enigmatic strongly-correlated-electron systems and offers a fertile testing ground for new concepts in condensed matter science. In spite >30 years intense research, no consensus on order parameter its low-temperature hidden-order phase exists. A strong magnetic field transforms hidden into magnetically-ordered phases, whose has also been defying experimental observation. Here, thanks to an instrumentation breakthrough high-field neutron scattering, we identify...
Generation of high-affinity Ab is impaired in mice lacking germinal center-associated DNA primase (GANP) B cells. In this study, we examined the effect its overexpression ganp transgenic C57BL/6 (Ganp(Tg)). Ganp(Tg) displayed normal phenotype cell development, serum Ig levels, and responses against T cell-independent Ag; however, it generated with much higher affinity nitrophenyl-chicken gammaglobulin comparison C57BL/6. To further examine increase, established hybridomas producing mAbs...
Early and specific diagnosis is critical for treatment of cholangiocarcinoma ( CCA ). In this study, a carbohydrate antigen‐S27 CA ‐ S 27) monoclonal antibody (m A b) was established using pooled tissue‐extract as immunogen. The epitope recognized by 27‐m b new L ewis‐a e ) associated modification MUC 5 AC mucin. oybean agglutinin/ ‐S27‐m sandwich ELISA to determine 27 in serum successfully developed. High level detected patients could differentiate from those gastro‐intestinal cancers,...
Acquired immunity depends on proliferation and differentiation of antigen (Ag)-specific B cells in germinal centers (GCs) lymphoid follicles response to T cell-dependent Ags. Here, we studied the function GC-associated nuclear protein that is selectively up-regulated GC-B cells. cell-specific ganp -deficient mice were compromised affinity maturation hapten-specific antibodies against Ags with retarded development GCs. cell numbers development, serum Ig levels, mitogen-induced vitro ,...
Abstract Lymphomas arise containing abnormalities of various differentiation stage-specific molecules. In the study reported here, we have shown abnormal up-regulation germinal center B cell–associated GANP in human lymphomas including mantle cell, diffuse large and Hodgkin lymphoma, by immunohistochemical analysis. To role lymphomagenesis, generated mutant mice (ganp-Tg) that express transgenic ganp gene under immunoglobulin enhancer promoter control. Ganp-Tg showed a high incidence...
We report neutron diffraction measurements on $\mathrm{U}({\mathrm{Ru}}_{0.96}{\mathrm{Rh}}_{0.04}{)}_{2}{\mathrm{Si}}_{2}$ single crystal under pulsed high magnetic fields up to 30 T applied along the tetragonal $c$ axis. The high-field experiments revealed that field-induced phase II above 26 corresponds a commensurate up-up-down ferrimagnetic structure characterized by wave vector $\mathbit{q}=(2/3,0,0)$ with moments parallel axis, which naturally explains one-third magnetization plateau...
There have been few case reports on fatal outcomes in patients with acute myocarditis after mRNA coronavirus disease 2019 (COVID-19) vaccination. In most cases of COVID-19 vaccination, the is mild, and prognosis good. Here we report an autopsy fulminant following vaccination.The global distribution vaccine requires consideration appropriate treatment for postvaccination myocarditis. Eosinophil-mediated immunological injury to cardiomyocytes can be involved cause inflammation from...