A5045709662- Distributed and Parallel Computing Systems
- Parallel Computing and Optimization Techniques
- Animal Disease Management and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Advanced Data Storage Technologies
- Cloud Computing and Resource Management
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Renal Transplantation Outcomes and Treatments
- Photonic and Optical Devices
- T-cell and Retrovirus Studies
- Animal Virus Infections Studies
- Transplantation: Methods and Outcomes
- Scientific Computing and Data Management
- Pancreatic function and diabetes
- Semiconductor Lasers and Optical Devices
- Optical Network Technologies
- Caching and Content Delivery
- Hepatitis C virus research
- Interconnection Networks and Systems
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Embedded Systems Design Techniques
- Microbial infections and disease research
University of Miyazaki
2016-2025
Sendai Shakai Hoken Hospital
2025
Hokkaido University
1993-2024
Sendai City Hospital
2016-2021
University of Veterinary Medicine
2021
ProQuest (United States)
2019
Fujitsu (Japan)
2006-2018
Photonics Electronics Technology Research Association
2006-2018
National Institute of Animal Health
2017
National Agriculture and Food Research Organization
2017
Abstract The details of the mechanism by which severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes pneumonia are unclear. We investigated immune responses and pathologies SARS-CoV-infected BALB/c mice that were immunized intradermally with recombinant vaccinia virus (VV) expressed either SARS-CoV spike (S) protein (LC16m8rVV-S) or simultaneously all structural proteins, including nucleocapsid (N), membrane (M), envelope (E), S proteins (LC16m8rVV-NMES) 7–8 wk before...
The Grid Datafarm (Gfarm) architecture is designed for global petascale data-intensive computing. It provides a parallel filesystem with online storage, scalable I/O bandwidth, and processing, it can exploit local in grid of clusters tens thousands nodes. Gfarm APIs commands provide single image manipulate metadata consistently. Fault tolerance load balancing are automatically managed by file duplication or recomputation using command history log. Preliminary performance evaluation has shown...
The lack of a small-animal model has hampered the analysis hepatitis C virus (HCV) pathogenesis. tupaia (Tupaia belangeri), tree shrew, shown susceptibility to HCV infection and been considered possible candidate for small experimental infection. However, longitudinal HCV-infected tupaias yet be described. Here, we provide an pathogenesis during course in over 3-year period. animals were inoculated with patient serum HCR6 or viral particles reconstituted from full-length cDNA. In either...
IaaS (Infrastructure-as-a-Service) is an emerging concept of cloud computing, which allows users to obtain hardware resources from virtualized data centers. Although many commercial clouds have recently been launched, dynamic virtual machine (VM) migration not possible among service providers; are locked into a particular provider, and cannot transparently relocate their VMs another one for the best cost-effectiveness. In this paper, we propose advanced storage access mechanism that strongly...
Lipids are key components in the viral life cycle that affect host-pathogen interactions. In this study, we investigated effect of HCV infection on sphingolipid metabolism, especially endogenous SM levels, and relationship between replication molecular species. We demonstrated induces expression genes (SGMS1 2) encoding human synthases 1 2. observed associated increases both total individual species, as assessed hepatocytes detergent-resistant membrane (DRM) fraction which replicates. SGMS1...
In the event of a new infectious disease outbreak, mathematical and simulation models are commonly used to inform policy by evaluating which control strategies will minimize impact epidemic. early stages such outbreaks, substantial parameter uncertainty may limit ability provide accurate predictions, policymakers do not have luxury waiting for data alleviate this state uncertainty. For policymakers, however, it is selection optimal intervention in face uncertainty, rather than accuracy model...
The ubiquitin pathway functions in the process of protein turnover eukaryotic cells. This comprises enzymes that ubiquitinate/deubiquitinate target proteins and proteasome degrades ubiquitin-conjugated proteins. Ubiquitin C-terminal hydrolases (UCHs) are thought to be essential for maintaining ubiquitination activity by releasing (Ub) from its substrates. Mammalian UCH-L1 UCH-L3 small share considerable homology at amino acid level. Both these UCHs highly expressed testis/ovary neuronal Our...
Ubiquitination is required throughout all developmental stages of mammalian spermatogenesis. Ubiquitin C-terminal hydrolase (UCH) L1 thought to associate with monoubiquitin control ubiquitin levels. Previously, we found that UCHL1-deficient testes gad mice have reduced levels and are resistant cryptorchid stress-related injury. Here, analyzed the function UCHL1 during first round spermatogenesis sperm maturation, both which known require ubiquitin-mediated proteolysis. Testicular germ cells...
Dynamic consolidation of virtual machines (VMs) through live migration is a promising technology for IaaS datacenters. VMs are dynamically packed onto fewer server nodes, thereby eliminating excessive power consumption. Existing studies on VM consolidation, however, based precopy migration, which requires dozens seconds to switch the execution hosts VMs. It difficult optimize locations quickly sudden load changes, resulting in serious violations performance criteria. In this paper, we...
The perinatal transmission of bovine leukaemia virus (BLV) plays a critical role in the spread and persistence BLV infection cattle herds. purpose this study was to examine frequency infections an area Japan investigate some risk factors associated with infection. Altogether, 129 calves born BLV-infected cows herd were tested for immediately after birth again at one month age using nested PCR. Twenty-four (18.6 per cent) infected BLV, which 14 (10.8 10 (7.7 via transplacental canal routes,...
Bovine viral diarrhea (BVD) is caused by the BVD virus (BVDV) and has been reported worldwide in cattle. To estimate BVDV circulation among cattle where few cases were southern Japan, 1910 serum samples collected from 35 farms without a outbreak investigated to detect antibodies against BVDV-1 BVDV-2 using an indicator with cytopathogenic effect luciferase gene, respectively. Neutralizing detected more frequently 18 vaccinated than 17 nonvaccinated farms. In farms, 9.6%, 1.8%, 13.8% of...
Background. Humoral rejection after ABO-incompatible liver transplantation often causes graft loss and a life-threatening situation. We used rituximab, which can eliminate B cells highly selectively, as an additional therapy for living-related transplantation. Cases. Patient 1 was 1-year-old girl with biliary atresia. Her blood type O, the donor's A. She underwent two plasma exchanges before had triple immunosuppressants (mycophenolate mofetil, tacrolimus, methylprednisolone). diagnosed...
We are developing an efficient resource management system with aggressive virtual machine (VM) relocation among physical nodes in a data center. Existing live migration technology, however, requires long time to change the execution host of VM, it is difficult optimize VM packing on dynamically, corresponding ever-changing usage. In this paper, we propose advanced mechanism enabling instantaneous VMs. To minimize needed for switching host, memory pages transferred after resumes at...