A5022462467- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Reproductive Biology and Fertility
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginger and Zingiberaceae research
- Sperm and Testicular Function
- Traditional Chinese Medicine Analysis
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Genomics, phytochemicals, and oxidative stress
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Medicinal Plants and Neuroprotection
- Osteoarthritis Treatment and Mechanisms
- Bee Products Chemical Analysis
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Prion Diseases and Protein Misfolding
- Diet, Metabolism, and Disease
- Preterm Birth and Chorioamnionitis
- Neonatal Health and Biochemistry
Jeonbuk National University
2015-2025
Kerala Veterinary and Animal Sciences University
2015
Chonbuk National University Hospital
2011-2014
National Center of Neurology and Psychiatry
2004-2007
National Neuroscience Institute
2007
The University of Tokyo
2003-2006
The ubiquitin pathway functions in the process of protein turnover eukaryotic cells. This comprises enzymes that ubiquitinate/deubiquitinate target proteins and proteasome degrades ubiquitin-conjugated proteins. Ubiquitin C-terminal hydrolases (UCHs) are thought to be essential for maintaining ubiquitination activity by releasing (Ub) from its substrates. Mammalian UCH-L1 UCH-L3 small share considerable homology at amino acid level. Both these UCHs highly expressed testis/ovary neuronal Our...
Ubiquitination is required throughout all developmental stages of mammalian spermatogenesis. Ubiquitin C-terminal hydrolase (UCH) L1 thought to associate with monoubiquitin control ubiquitin levels. Previously, we found that UCHL1-deficient testes gad mice have reduced levels and are resistant cryptorchid stress-related injury. Here, analyzed the function UCHL1 during first round spermatogenesis sperm maturation, both which known require ubiquitin-mediated proteolysis. Testicular germ cells...
Ubiquitin carboxyl-terminal hydrolase 1 (UCH-L1) can be detected in mouse testicular germ cells, mainly spermatogonia and somatic Sertoli but its physiological role is unknown. We show that transgenic (Tg) mice overexpressing EF1α promoter-driven UCH-L1 the testis are sterile due to a block during spermatogenesis at an early stage (pachytene) of meiosis. Interestingly, almost all cells expressing excess UCH-L1, little PCNA (proliferating cell nuclear antigen), showed no morphological signs...
This study was designed to investigate the incidence of ectoparasite infestation among stray dogs in Gwang-ju City, Republic Korea. A total 103 collected Animal Shelter City from November 2003 August 2005 were investigated this study. Ectoparasites one or more genera detected 45.6% (47 / 103) examined for dermatologic lesions and/or skin scrapings (from 3-5 affected areas). Otodectes cynotis found be most frequent parasite (22.3%, 23 103), followed by Sarcoptes scabiei var canis (19.4%, 20...
The beneficial effects of ginsenoside species have been well demonstrated in a number studies. However, the function Ro (GRo), an oleanane-type saponin, has not sufficiently investigated. Thus, aim present study was to investigate anti-inflammatory GRo vitro using Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and clarify possible mechanism involving heme oxygenase-1 (HO-1), which itself plays critical role self-defense presence inflammatory stress. cells were...
Abstract Recently, a possible link between toll-like receptor 7 (TLR7) and liver disease was suggested, although it limited to fibrosis. Based on this report, we investigated whether TLR7 has pivotal role in non-alcoholic fatty (NAFLD). The signaling pathway, which is activated by imiquimod (TLR7 ligand) naturally, induced autophagy released insulin-like growth factor 1 (IGF-1) into medium from hepatocytes. Lipid accumulation unsaturated acid (UFA; arachidonic acid:oleic = 1:1) hepatocytes,...
Background and Objectives: Acute gastric injury is a prevalent gastrointestinal disorder characterized by inflammation damage to the stomach lining. In this study, we investigated therapeutic potential effects of broccoli stem extract (BSE) against acute gastritis in rat model. Materials Methods: The antioxidant properties BSE were evaluated through DPPH ABTS radical scavenging activity assays total polyphenol content analysis. was induced using 150 mM HCl/60% EtOH, male SD rats (6-weeks...
Abstract Background Metabolic syndrome (MetS) refers to a group of risk factors that cause health problems, such as obesity, diabetes, dyslipidemia, and hyperglycemia. MetS is characterized by insulin resistance, which leads abnormal sensitivity. Cirsium japonicum var. maackii (CJ) perennial herbaceous species found in Asia exhibits antioxidant, antidiabetic, antitumor, antifungal, anti-inflammatory activities. In this study, we aimed measure the effects CJ on improving resistance db/db type...
Advanced glycation end-products (AGEs) and their receptor cause diabetic liver disease by increasing oxidative stress inflammation. We investigate the potential therapeutic benefits of Cirsium japonicum (CJ) in preventing progression diabetes, focusing on complications for both kidney health associated with AGEs. Streptozotocin (STZ, 30 mg/kg) was injected into SD rats CJ (50, 100 orally administered 4 weeks. treatment led to a marked reduction key markers (glucose, reaction oxygen species,...
The gracile axonal dystrophy (gad) mice are known to have a deletion within the gene encoding ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) and show hereditary sensory deterioration motor paresis. Expression of Uch-L1 is reported be almost limited nervous system testis. To understand whether Uch-L1, one major hydrolase (UCH) isozymes in testis, affects spermatogenesis other UCH (Uch-L3, L4 L5) expression we compared testis between gad, hetero wild type by histological, immunohistochemical...
Neuronal apoptosis induced by oxidative stress is a prominent feature of neurodegenerative disorders. [6]-shogaol, bio-active compound in ginger, possesses potent anti-inflammatory actions and has recently emerged as potential therapeutic agent for However, the effects [6]-shogaol on astroglial following exogenously not yet been investigated. Here, we show that anti-apoptotic activity astrocytes exposure to hydrogen peroxide (H2 O2 ) involves marked up-regulation neurotrophic factors such...