A5101635531- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Medicinal Plants and Bioactive Compounds
- Cholesterol and Lipid Metabolism
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Free Radicals and Antioxidants
- Medicinal Plants and Neuroprotection
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Bioactive natural compounds
- Fungal Biology and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Chemotherapy-induced organ toxicity mitigation
- Adipose Tissue and Metabolism
Hallym University
2005-2024
Severance Hospital
2023
Rural Development Administration
2016-2022
Farm Foundation
2021
Government of the Republic of Korea
2016-2019
National Horticultural Research Institute
2016-2019
Pusan National University
2013-2017
Daegu Haany University
2014-2017
Catholic University of Daegu
2016
Korea Research Institute of Bioscience and Biotechnology
2012-2014
Two Rokumi-jio-gan-containing prescriptions (Hachimi-jio-gan and Bakumi-jio-gan) were selected to examine their actions in nephrectomized rats. Each prescription was given orally rats for 10 weeks after the excision of five-sixths kidney volumes, its effect compared with non-nephrectomized normal Rats Hachimi-jio-gan Bakumi-jio-gan showed an improvement renal functional parameters such as serum urea nitrogen, creatinine, creatinine clearance, urinary protein. The exhibited up-regulation...
Skin aging is a multisystem degenerative process caused by several factors, such as, UV irradiation, stress, and smoke. Furthermore, wrinkle formation striking feature of photoaging associated with oxidative stress inflammatory response. In the present study, we investigated whether caffeic acid, S-allyl cysteine, uracil, which were isolated from garlic, modulate UVB-induced effect expression matrix-metalloproteinase (MMP) NF-κB signaling. The results obtained showed that all three compounds...
Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from methanol extracts <i>Psoralea corylifolia</i> by bioactivity-guided fractionation. The structures bakuchiol (<b>1</b>), bavachinin (<b>2</b>), neobavaisoflavone (<b>3</b>), corylifol A (<b>4</b>), corylin (<b>5</b>), isobavachalcon (<b>6</b>), and bavachin (<b>7</b>) determined spectroscopic analysis...
Heptadecane is a volatile component of Spirulina platensis, and blocks the de novo synthesis fatty acids ameliorates several oxidative stress-related diseases. In redox state disrupted by stress, pro-inflammatory genes are upregulated activation NF-kB via diverse kinases. Thus, search characterization new substances that modulate lively research topics. present study, heptadecane was examined in terms its ability to suppress inflammatory redox-related NIK/IKK MAPKs pathway aged rats. first...
In our previous study, we reported the renoprotective effect of Hachimi-jio-gan, a Chinese traditional prescription consisting eight medicinal plants, and also Corni Fructus (Cornus officinalis SIEB. et ZUCC.), component on diabetic nephropathy using rats. this investigated effects morroniside isolated from renal damage in streptozotocin-treated Oral administration at dose 20 or 100 mg/kg body weight/d for d to rats resulted significant decreases increasing serum glucose urinary protein...
The present study was conducted to examine whether morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Morroniside (20 or 100 mg/kg body weight/d, per os (p.o.)) administered every day for 8 weeks mice, its compared with vehicle-treated m/m administration decreased elevated serum glucose concentration reduced increased biomarkers including generation reactive oxygen species...
We have identified the effects of oligonol, a low-molecular polyphenol derived from lychee fruit, on oxidative stress and lipid metabolism in type 2 diabetic model. Oligonol was orally administered at 10 or 20 mg per kg body weight d for 8 weeks to db/db mice, its were compared with those vehicle m/m mice. Serum hepatic biochemical factors, protein mRNA expression related measured. In oligonol-administered group, there significant reductions reactive oxygen species (ROS), peroxidation, TAG...
This study was conducted to compare the protective effects of astaxanthin (ASX) with Corni Fructus (CF) against diabetes-induced pathologies such as oxidative stress-induced inflammation and advanced glycation end product (AGE) formation in liver type 1 diabetic rats. ASX (50 mg/kg body weight/day) or CF (200 orally administered every day for 18 days streptozotocin (STZ)-induced rats, their were compared nondiabetic control The administration CF, but not ASX, decreased both elevated serum...
Cholinergic dysfunction and oxidative stress are the most common causes of Alzheimer's disease (AD). Safflower seed contains various anti-oxidant cholinergic improvement compounds, such as serotonin its derivatives. In present study, we investigated protective effects mechanisms a safflower extract on scopolamine-induced memory impairment in mouse model. The was orally administered at dose 100 mg kg-1 day-1, then behavior tests (such T-maze novel object recognition tests) were conducted....
The effect of morroniside on lipid metabolism and the inflammatory response in liver type 2 diabetes model mice was investigated this study. Male C57BLKS/J db/db were divided into three groups: control (vehicle), 20, or 100 mg/kg body weight-treated mice. elevated serum triglyceride alanine aminotransferase levels as well hepatic glucose lipids contents significantly decreased by 8-week oral administration a dose-dependent manner. generations thiobarbituric acid-reactive substances reactive...
We investigated the antidiabetic potential of proanthocyanidin and its oligomeric form in STZ-induced diabetic model rats db/db type 2 mice. Proanthocyanidin ameliorated condition by significant decreases serum glucose, glycosylated protein, urea nitrogen as well urinary protein renal-AGE decrease glucose The suppression ROS generation elevation GSH/GSSG ratio were also observed groups administered proanthocyanidin. Moreover, proanthocyanidin, especially form, affected inflammatory process...
Skeletal muscle atrophy results from various conditions including high levels of glucocorticoids, and β–hydroxy β–methylbutyrate (HMB; a metabolite leucine) is potent therapeutical supplement used to treat disorders. Recent studies have demonstrated that HMB inhibits dexamethasone-induced in cultured myotubes, but its effect on has not been determined vivo. In the present study, we investigated rats. Treatment with dexamethasone weakened grip strengths increased damage as by serum creatine...
Abstract Although Hif‐2α is a master regulator of catabolic factor expression in osteoarthritis development, inhibitors remain undeveloped. The aim this study was to determine whether Cirsium japonicum var. maackii (CJM) extract and one its constituents, apigenin, could attenuate the Hif‐2α‐induced cartilage destruction implicated progression. In vitro vivo studies demonstrated that CJM reduced IL‐1β‐, IL‐6, IL‐17‐ TNF‐α‐induced up‐regulation MMP3, MMP13, ADAMTS4, ADAMTS5 COX‐2 blocked...
Diabetes is the leading cause of end-stage renal failure, since glucose-dependent metabolic factors are synergistically activated within diabetic kidney. Accordingly, in Japan, there much debate over health benefits natural therapies to reduce these risk factors. In our previous study, we reported that Cornus officinalis SIEB. et ZUCC. possessed an antidiabetic effect via ameliorating glucose-mediated disorders as well aminoguanidine, inhibitor advanced glycation endproduct (AGE) formation,...
The effects of morroniside isolated from Corni Fructus on renal lipids and inflammation provoked by hyperglycaemia were investigated using type 2 diabetic mice.Morroniside was administered orally to db/db mice at 20 or 100 mg/kg daily for 8 weeks, its compared with those in vehicle-treated m/m (non-diabetic) mice. Serum biochemical factors protein expression related lipid homeostasis measured.Morroniside produced significant dose-dependent reductions serum triglyceride glucose levels....
Green tea, prepared from the leaves of Camellia sinensis L., is a beverage that popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for maintenance human health due to their varied biological activity and low toxicity. In particular, contribution antioxidant prevention diseases caused by oxidative stress has focused upon. Therefore, this study, we investigated effects (−)-epigallocatechin 3- O -gallate -gallate, which account large fraction...
Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a mouse model inflammation-induced memory cognitive deficit.C57BL/6 mice were injected with lipopolysaccharide (LPS; 2.5 mg/kg, intraperitoneally) orally administrated SW extract (150 mg/kg/day). SW, new species Korea, was combined uralensis glabra. Behavioral tests, including...