Plants constantly monitor environmental fluctuations to optimize their growth and metabolism. One example is adaptive occurring in response biotic abiotic stresses. Here, we demonstrate that GH3-mediated auxin homeostasis an essential constituent of the complex network actions regulates stress adaptation responses Arabidopsis. Endogenous pool regulated, at least part, through negative feedback by a group auxin-inducible GH3 genes encoding auxin-conjugating enzymes. An Arabidopsis mutant,...

Cold signals interact with other environmental cues to modulate plant developmental processes. Recent studies have shown that many Pathogenesis-Related (PR) genes are induced and disease resistance is enhanced after exposure low temperatures, linking cold pathogenesis in plants. However, the underlying molecular mechanisms signaling schemes largely unknown. Here, we demonstrate stimulates proteolytic activation of a plasma membrane-tethered NAC (NAM/ATAF1/2/CUC2) transcription factor NTL6....

The appropriate timing of flowering is pivotal for reproductive success in plants; thus, it not surprising that regulated by complex genetic networks are fine-tuned endogenous signals and environmental cues. Arabidopsis thaliana flowering-time gene SUPPRESSOR OF OVEREXPRESSION CONSTANS1 (SOC1) encodes a MADS box transcription factor one the key floral activators integrating multiple inductive pathways, namely, long-day, vernalization, autonomous, gibberellin-dependent pathways. To elucidate...

The assessment of rupture probability is crucial to identifying at risk intracranial aneurysms (IA) in patients harboring multiple aneurysms. We aimed develop a computer-assisted detection system for small-sized aneurysm ruptures using convolutional neural network (CNN) based on images three-dimensional digital subtraction angiography. A retrospective data set, including 368 patients, was used as training cohort the CNN TensorFlow platform. Aneurysm six directions were obtained from each...

Objectives The correlation of optic nerve sheath diameter (ONSD) as seen on ultrasonography (US) and directly measured intracranial pressure (ICP) has been well described. Nevertheless, differences in ethnicity type ICP monitor used are obstacles to the interpretation. Therefore, we investigated direct between ONSD ventricular defined an optimal cut-off point for identifying increased (IICP) Korean adults with brain lesions. Methods This prospective study included patients who required...

OBJECT Moyamoya disease (MMD) is a rare cerebrovascular and its natural history still unclear. The authors aimed to investigate the course of hemodynamically stable cases adult MMD, with analysis stroke risk factors. METHODS Two hundred forty-one patients were included in this retrospective study. One sixty-six (68.9%) female, mean age (± SD) at first visit was 41.3 ± 12.0 years (range 18–69 years). Unilateral involvement identified 33 patients, 19 (7.9%) had family MMD. According clinical...

Watercress (Nasturtium officinale R. Br.) is an aquatic herb species that a rich source of secondary metabolites such as glucosinolates. Among these glucosinolates, watercress contains high amounts gluconasturtiin (2-phenethyl glucosinolate) and its hydrolysis product, 2-phennethyl isothiocyanate, which plays role in suppressing tumor growth. However, the use N. herbal medicines currently limited due to insufficient genomic physiological information. To acquire precise information on...

Brain magnetic resonance imaging (MRI) is useful for predicting the outcome of patients with acute ischemic stroke (AIS). Although deep learning (DL) using brain MRI certain image biomarkers has shown satisfactory results in poor outcomes, no study assessed usefulness natural language processing (NLP)-based machine (ML) algorithms free-text reports AIS patients. Therefore, we aimed to assess whether NLP-based ML text could predict outcomes This included only English MRIs examined during...

Acute vertebrobasilar occlusion can led to a fatal outcome, but lack of established procedures poses many difficulties in its management. Although mechanical thrombectomy (MT) has shown positive outcomes recently, high reocclusion rate remains hurdle. This study is share experience and review technical challenges rescue angioplasty and/or stenting (RAS) for refractory occlusions after MT posterior circulation ischemic stroke (PCIS). Out 494 patients with acute from January 2014 December 2022...

One of the major obstacles to neural recovery following intracerebral hemorrhage (ICH) is cavity-like lesion that occurs at site hemorrhage, which impedes axonal regeneration. Here, we aim address this challenge by investigating migratory mechanisms stem cells (NSCs) within cavity in vitro using a hydrogel and endothelial cells. Mouse NSCs (mNSCs) isolated from subventricular subgranular zones 3D culture were evaluated for their neurogenic, extracellular matrix (ECM), adhesion-related mRNA...

Although a transvenous route via the ipsilateral inferior petrosal sinus (IPS) is preferred in treating cavernous dural arteriovenous fistula (CSdAVF), this option may be limited if an occluded IPS undermines microcatheter delivery to sinus.To describe our experience with endovascular treatment of CSdAVF complicated by occlusion.From January 2003 through September 2014, total 49 CSdAVFs occlusion were identified patients, who then underwent treatment. Clinical and radiologic data...

This study was conducted to evaluate a problem-oriented focused torso bedside ultrasound protocol termed "Sonographic Evaluation of Aetiology for Respiratory difficulty, Chest pain, and/or Hypotension" (SEARCH 8Es) its ability narrow differential diagnoses and increase physicians' diagnostic confidence, accuracy, patients presenting with dyspnea, chest or symptomatic hypotension.This single-center prospective observational over 12 months in an emergency department included 308 (184 men 124...

Optic nerve sheath diameter (ONSD) seen on ocular US has been associated with increased intracranial pressure (IICP). However, most studies have analyzed normal range of ONSD and its optimal cut-off point for IICP in Caucasian populations. Considering differences according to ethnicity, previous results may not accurately reflect the association between Koreans. Therefore, we conducted this study investigate threshold detecting Korean patients. This prospective multicenter was performed...

To compare peri-operative any symptomatic stroke after carotid angioplasty and stenting (CAS), based on the application or absence of a cerebral protection device.A systematic literature review using PubMed, Embase, Cochrane Central was done across an online data base from January 1995 to October 2016. Procedures which were performed due dissection aneurysm, procedures covered stents conducted in emergency, excluded. The primary endpoint perioperative within 30 days procedure. A fixed effect...

Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) IA a Korean population consisting 250 patients, 294 controls using Asian-specific Axiom Precision Medicine Research Array. Twenty-nine SNPs reached genome-wide significance threshold (5 × 10−8). The rs371331393 SNP, stop-gain function ARHGAP32...

Auto-detection of cerebral aneurysms via convolutional neural network (CNN) is being increasingly reported. However, few studies to date have accurately predicted the risk, but not diagnosis itself. We developed a multi-view CNN for prediction rupture risk involving small unruptured intracranial (UIAs) based on three-dimensional (3D) digital subtraction angiography (DSA). The performance CNN-ResNet50 in predicting (high vs. non-high) UIAs anterior circulation measuring less than 7 mm size...

Abstract The catalytic performance and therapeutic effect of nanoparticles varies with shape. Here, we investigated compared the outcomes ceria nanospheres (Ceria NSs) nanorods NRs) in an vivo study mild traumatic brain injury (mTBI). In TBI was induced a mouse model open head using stereotaxic impactor. Outcomes including cytoprotective effects, cognitive function, cerebral edema were after retro-orbital injection 11.6 mM nanoparticles. Ceria significantly reduced fluoro-jade B...

Advanced glycation end-products (AGEs) and their receptor cause diabetic liver disease by increasing oxidative stress inflammation. We investigate the potential therapeutic benefits of Cirsium japonicum (CJ) in preventing progression diabetes, focusing on complications for both kidney health associated with AGEs. Streptozotocin (STZ, 30 mg/kg) was injected into SD rats CJ (50, 100 orally administered 4 weeks. treatment led to a marked reduction key markers (glucose, reaction oxygen species,...

Background: Despite the important clinical issue of cognitive impairment after moderate traumatic brain injury (TBI), there is currently no suitable treatment. Here, we used in vitro and vivo models to investigate effect Donepezil—an acetylcholinesterase (AChE) inhibitor—on acute period following injury, while focusing on neuroinflammation autophagy- mitophagy-related markers. Methods: The purpose study was potential neuroprotective effects TBI-induced cells donepezil treatment, study,...