A5101623999- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Hydrogen embrittlement and corrosion behaviors in metals
- Head and Neck Surgical Oncology
- Non-Destructive Testing Techniques
- Intracranial Aneurysms: Treatment and Complications
- Nuclear Materials and Properties
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Facial Nerve Paralysis Treatment and Research
- Nuclear reactor physics and engineering
- Histone Deacetylase Inhibitors Research
- Lung Cancer Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- Advanced MRI Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Adrenal and Paraganglionic Tumors
- Neurological disorders and treatments
- Corrosion Behavior and Inhibition
Seoul National University
2012-2024
Seoul National University Bundang Hospital
2015-2024
New Generation University College
2011-2022
Armed Forces Capital Hospital
2021
Weatherford College
2021
Gyeongsang National University Hospital
2021
Samsung Medical Center
2007-2018
Seoul National University Hospital
2008-2017
National University College
2016
Korea Atomic Energy Research Institute
1994-2013
BACKGROUND A chemosensitizing effect of levetiracetam (LEV) has been suggested because LEV inhibits O‐6 methylguanine‐DNA methyltransferase (MGMT). However, the survival benefit not clinically documented. The objective this study was to assess compared with other antiepileptic drugs as a chemosensitizer temozolomide for patients glioblastoma. METHODS In total, 103 consecutive primary glioblastoma who received concomitant chemoradiotherapy and adjuvant chemotherapy were retrospectively...
Pseudoprogression is a major diagnostic dilemma in current treatment protocols for malignant gliomas that involve concurrent chemoradiotherapy. We hypothesized methylation-specific multiplex ligation probe amplification (MS-MLPA), an assay permits semiquantitative evaluation of promoter methylation, may be used to diagnose pseudoprogression based on the quantification methylation status O(6)-methylguanine DNA methyltransferase (MGMT) promoter. examined ratio MGMT with MS-MLPA 48 samples from...
BACKGROUND: A thorough investigation of the long-term outcomes central neurocytoma (CN) after different treatments is required to establish optimal management strategies. OBJECTIVE: We retrospectively reviewed clinical patients with CN according various and suggest treatment strategies based on 30 years experience in a single institution. METHODS: Fifty-eight consecutive were treated at our institution between 1982 2008. Patient demographics, overall survival, local control rates multimodal...
Supplementary motor area (SMA) resection often induces postoperative contralateral hemiparesis or speech disturbance. This study was performed to assess the neurological impairments that follow SMA and risk factors associated with these deficits.The records for patients who had undergone pharmacologically intractable epilepsy between 1994 2010 were gleaned from an surgery database retrospectively reviewed in this study.Forty-three underwent intraoperative cortical stimulation mapping while...
Optic nerve sheath diameter (ONSD) seen on ocular US has been associated with increased intracranial pressure (IICP). However, most studies have analyzed normal range of ONSD and its optimal cut-off point for IICP in Caucasian populations. Considering differences according to ethnicity, previous results may not accurately reflect the association between Koreans. Therefore, we conducted this study investigate threshold detecting Korean patients. This prospective multicenter was performed...
OBJECTIVE The electrode position is important to the surgical outcome after subthalamic nucleus (STN) deep brain stimulation (DBS). aim of this study was compare bilateral STN DBS with estimated using fused magnetic resonance imaging. METHODS Bilateral performed in 60 patients advanced Parkinson's disease. Patients were evaluated Unified Disease Rating Scale, Hoehn and Yahr staging, Schwab England Activities Daily Living, L-dopa equivalent dose, Short Form-36 Health Survey before at 3 6...
Abstract BACKGROUND. Little is known about long‐term results of gamma knife (GK) stereotactic radiosurgery (SRS) as a primary or secondary postoperative therapy for central neurocytomas (CNs). The authors retrospectively reviewed outcomes 13 patients with CN treated GK SRS. METHODS. Thirteen were SRS (6 patients) (7 patients). Follow‐up clinical status and brain magnetic resonance imaging (MRI) thoroughly analyzed. functional was assessed the Karnofsky Performance Scale during follow‐up....
Object In this paper the authors analyzed clinical and neuroimaging outcomes of patients with cerebral arteriovenous malformations (AVMs) after Gamma Knife surgery (GKS), focusing on analysis radiation injury rate depending AVM volume. Methods Between 1997 2004, 277 consecutive AVMs were treated GKS. Of these patients, 218 followed up for ≥ 2 years. The mean age was 31 ± 15 years, median volume 3.4 cm 3 (range 0.17–35.2 ), marginal dose 18.0 Gy 10.0–25.0 Gy), follow-up duration 44 20 months....
Surgical resection still remains the mainstay of treatments for large brain metastases if feasible. Recently, stereotactic radiosurgery (SRS) using low-dose, 11- to 12-Gy marginal prescription dose, was tried document benefit patients with when it used as a primary or salvage treatment. Many responded promptly and showed favorable outcome after SRS. More than half recovered from their neurological deficits within 1 month However, not negligible portion were suffered adverse radiation effects...
The prognosis of patients diagnosed with glioblastoma remains dismal in spite the current concomitant chemoradiotherapy temozolomide. In particular, resistance to temozolomide appears be greatest obstacle treatment glioblastoma. present study, we evaluated vitro and vivo antitumor effects combination therapy cilengitide belotecan, a camptothecin derivate, treat experimental therapeutic drugs on U87MG U251MG human cell lines were assessed using viability apoptosis assays. group belotecan...
The authors aimed to assess whether the prevalence of intracranial aneurysms in patients with meningiomas was higher than that a healthy population.The performed hospital-based case-control study 300 newly diagnosed and 900 age- sex-matched controls without history brain tumors evaluate any associations between meningiomas. Unconditional multivariate logistic regression models were used for comparisons.Intracranial identified 23 (7.7%) 24 (2.7%; p < 0.001). There significant association (OR...