A5052540132- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Diverse Approaches in Healthcare and Education Studies
- Estrogen and related hormone effects
- Ovarian function and disorders
- Menopause: Health Impacts and Treatments
- Minimally Invasive Surgical Techniques
- Ovarian cancer diagnosis and treatment
- Food Quality and Safety Studies
- Psychosocial Factors Impacting Youth
- Healthcare and Venom Research
- Education and Learning Interventions
- Educational Systems and Policies
- Health and Wellbeing Research
- Bone health and osteoporosis research
- Diverse Topics in Contemporary Research
- Agriculture, Soil, Plant Science
- Preterm Birth and Chorioamnionitis
- Phytoestrogen effects and research
- Healthcare Education and Workforce Issues
- Maternal and fetal healthcare
Seoul St. Mary's Hospital
2016-2025
Catholic University of Korea
2016-2025
Korea Institute of Brain Science
2024
Korea Institute of Science and Technology
2024
Korean Association Of Science and Technology Studies
2024
Chonnam National University Hospital
2009-2024
Jeonju University
2024
Daejeon Sun Hospital
2024
Seoul National University Hospital
2003-2024
Semyung University
2020-2023
Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental (PIGF), and their receptors is important for effective vasculogenesis, angiogenesis, development. Recently, soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF PIGF, has been implicated in pathophysiology pre-eclampsia. Plasma sVEGFR-1 concentration elevated pre-eclampsia at time clinical diagnosis correlates with severity disease. The purpose this study was determine whether...
Abstract Recurrent somatic mutations in MED12 exon 2 have recently been reported uterine leiomyomas. The recurrent nature of the strongly suggests that may play important roles pathogenesis aim our study was to see whether occur other human tumors besides We also attempted confirm occurrence leiomyomas Korean patients. For this, we analyzed 1,862 tumor tissues, including a variety carcinomas, leukemias and stromal by single‐strand conformation polymorphism analysis. found 35 (35/67; 52.2%)...
The assessment of rupture probability is crucial to identifying at risk intracranial aneurysms (IA) in patients harboring multiple aneurysms. We aimed develop a computer-assisted detection system for small-sized aneurysm ruptures using convolutional neural network (CNN) based on images three-dimensional digital subtraction angiography. A retrospective data set, including 368 patients, was used as training cohort the CNN TensorFlow platform. Aneurysm six directions were obtained from each...
This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and negative impact on women's quality life. Furthermore, advancement our understanding this condition requires quantum shift based new theories pathogenesis. With conviction, international calls for may improve condition, leading optimized management or even prevention. To facilitate this, dedicated website serving as repository where all proposed can be...
The aim of this study was to examine the appropriateness chemotherapy and care in Korean cancer patients near end-of-life.We designed a retrospective cohort composed diagnosed as having metastatic who received palliative at Seoul National University Hospital 2002. Two hundred ninety-eight died were evaluated terms cancer-care they received, including chemotherapy.Median duration 6.02 months compared with 8.67 for median overall survival. period between last death 2.02 months. Of 298...
An age-dependent acceleration of apoptosis occurs in female germ cells (oocytes), and this requires communication between the oocyte its surrounding somatic (cumulus) cells. Here we show aged mice that ceramide is translocated from cumulus into adjacent induces cell can be prevented by sphingosine-1-phosphate. Trafficking gap junction-dependent as well intact lipid rafts. Further, occurrence elevated incidence oocytes females concomitant with an enhanced sensitivity to a spike cytosolic...
Preeclampsia has been considered an anti-angiogenic state. Two factors have implicated in the genesis of this state: soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and placental (PlGF). Indeed, concentrations PlGF, angiogenic factor, are lower preeclampsia than normal pregnancy, while opposite is case for sVEGFR-1. The source excess sVEGFR-1 not yet determined. Since placenta could be a sVEGFR-1, we conducted study to determine whether there gradient plasma concentration...
Nicotinic acetylcholine receptors (nAChRs) containing α6 subunits are expressed in only a few brain areas, including midbrain dopamine (DA) neurons, noradrenergic neurons of the locus ceruleus, and retinal ganglion cells. To better understand regional subcellular expression pattern α6-containing nAChRs, we created studied transgenic mice expressing variant subunit with green fluorescent protein (GFP) fused in-frame M3-M4 intracellular loop. In α6-GFP mice, α6-dependent synaptosomal DA...
Abstract Endometriosis consists of ectopic endometrial epithelial cells (EEECs) and stromal (EESCs) mixed with heterogeneous cells. To address how endometriosis‐constituting are different from normal endometrium among endometriosis subtypes their molecular signatures related to phenotypic manifestations, we analyzed ovarian cyst (OEC), superficial peritoneal (SPE), deep infiltrating (DIE) 12 patients using single‐cell RNA‐sequencing (scRNA‐seq). We identified 11 cell clusters, including...
Viral etiologic agents of acute lower respiratory tract infections were studied from November, 1990, through April, 1994, in Korean children. From 712 children who visited or admitted to Seoul National University Children's Hospital because infections, 804 nasal aspirates collected; viral detected by virus isolation and antigen was indirect immunofluorescent staining. One more identified 369 (45.9%) cases; which 3.3% mixed infections. The pathogens syncytial (27.2%), parainfluenza type 3...
Cells were isolated from four human amniotic membranes, and their biological characteristics analyzed during ex vivo expansion. Morphologically homogenous populations of fibroblast-like cells obtained the second or third passage. Under appropriate culture conditions, these membrane-derived mesenchymal (HAM) shown to differentiate into adipocytes, osteocytes, chondrocytes neuronal cells, as visualized by Oil Red O, von Kossa, alcian blue, anti-Neu N, anti-Gal C antibody staining,...
Osteocalcin, a marker of bone formation, is also known as regulator glucose and fat mass. The purpose this study was to determine the association between obesity, metabolic risks serum osteocalcin in postmenopausal women.We selected 214 women determined osteocalcin, fasting plasma (FPG), insulin, high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment insulin resistance (HOMA-IR), lipid profile, anthropometric values (body mass index [BMI], waist-to-hip ratio [WHR], body...
Korean ginseng (Panax C.A. Meyer) has been widely used for medicinal purposes and contains potent plant secondary metabolites, including ginsenosides. To obtain transcriptomic data that offers a more comprehensive view of functional genomics in P. ginseng, we generated genome-wide transcriptome from four different tissues using PacBio isoform sequencing (Iso-Seq) technology. A total 135,317 assembled transcripts were with an average length 3.2 kb high assembly completeness. Of those...