A5003728097- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Viral-associated cancers and disorders
- IgG4-Related and Inflammatory Diseases
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- Genetic Neurodegenerative Diseases
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Soft tissue tumor case studies
- Myasthenia Gravis and Thymoma
- Gastric Cancer Management and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
- Glycosylation and Glycoproteins Research
- Neonatal Health and Biochemistry
- Gallbladder and Bile Duct Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
Tokyo Metropolitan Komagome Hospital
2014-2024
Ebara Hospital
2014
Bridge University
2001
Jichi Medical University
1998
Shinonoi General Hospital
1995
Tokyo Medical and Dental University
1981-1986
✓ The authors analyzed 153 cases of histologically verified intracranial germ cell tumors. histological diagnosis was germinoma in 63 patients (41.2%), teratoma 30 (19.6%), and other types tumors 60 (39.2%). were treated by a consistent policy surgical removal with verification followed radiation therapy or without chemotherapy. 10- 20-year survival rates pure 92.7% 80.6%, respectively. 10-year mature malignant 92.9% 70.7%, Patients (embryonal carcinoma, yolk sac tumor, choriocarcinoma) had...
The novel stem cell marker SALL4 has been identified as a diagnostic of germ tumors, especially yolk sac in gonadal organs. To clarify the significance an oncofetal protein, we investigated expression by immunohistochemistry non-neoplastic stomach and gastric carcinoma with particular emphasis on á-fetoprotein (AFP)-producing carcinoma, AFP-producing shares AFP glypican 3 (GPC3) tumors hepatic neoplasms. A total 338 carcinomas, 60 hepatocellular 48 cholangiocellular carcinomas were studied...
Background. The prevalence of invasive fungal infection is increasing. An effective diagnostic test required to identify and treat them successfully. Methods. All autopsy records at our hospital for the period from January 2000 through December 2004 were reviewed cases infection. efficacy a serum (1→3)-β-d-glucan (β-glucan) assay was examined using only those in which patients had been tested within 2 weeks before death. Results. Of 456 autopsies, 54 (11.8%) involved Leukemias most frequent...
The lack of a small-animal model has hampered the analysis hepatitis C virus (HCV) pathogenesis. tupaia (Tupaia belangeri), tree shrew, shown susceptibility to HCV infection and been considered possible candidate for small experimental infection. However, longitudinal HCV-infected tupaias yet be described. Here, we provide an pathogenesis during course in over 3-year period. animals were inoculated with patient serum HCR6 or viral particles reconstituted from full-length cDNA. In either...
Abstract Epithelioid glioblastoma (E‐GBM) is a rare aggressive variant of IDH‐wildtype newly recognized in the 2016 World Health Organization classification, composed predominantly monotonous, patternless sheets round cells with laterally positioned nuclei and plump eosinophilic cytoplasm. Approximately 50% E‐GBM harbor BRAF V600E, which much less frequently found other types glioblastomas. Most are as primary/ de novo lesions; however, several co‐ or pre‐existing lower‐grade lesions have...
Vascular endothelial growth factor (VEGF) receptors consist of three cell-membrane type (VEGFR-1, VEGFR-2 and VEGFR-3), soluble form VEGFR-1 (sVEGFR-1), an intrinsic negative counterpart the VEGF. In this study, we measured intratumoral protein levels free total VEGF, sVEGFR-1 from 202 primary breast cancer tissues examined their prognostic values. A significant inverse correlation was found between or VEGF oestrogen receptor (ER) status (P=0.042 0.032, respectively). univariate analysis...
Macrophage migration inhibitory factor (MIF) is known to exert pleiotropic functions including inhibition of macrophage migration, anchoring, and counteraction the anti‐inflammatory immunosuppressive activity glucocorticoids. Ninety‐three primary breast cancer tissues 64 sera patients were analyzed for expression MIF. The clinico‐pathological significance MIF was evaluated. It found that frequently over‐expressed in tissues. RT‐PCR western blotting analysis confirmed wild‐type expressed,...
Persistent hepatitis C virus (HCV) infection often progresses to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Numerous viruses have been reported escape from apoptotic mechanism maintain persistent infection. In the present study, we characterized effect of HCV proteins on Fas signal using transgenic mice, which expressed core, E1, E2, NS2 proteins, regulated by Cre/loxP switching system. The transgene expression mice caused resistance antibody stimulated lethality. Apoptotic...
Shiga toxins (Stxs) are the major agents responsible for hemorrhagic colitis and hemolytic-uremic syndrome (HUS) during infections caused by Stx-producing Escherichia coli (STEC) such as serotype O157:H7. Central nervous system (CNS) involvement is an important determinant of mortality in diarrhea associated-HUS. It has been suggested that vascular endothelial injuries Stxs play a crucial role development disease. The current study investigates relationship between cytotoxic effects...
DNA hypermethylation may play a primary role in the genesis of Epstein‐Barr virus (EBV)‐associated gastric carcinoma (GC) (EB‐VaGC). Methylation‐specific PCR targeting CpG‐islands demonstrated markedly increased methylation specific genes, such as p14, p15 and p16 EBVaGC vivo . A high frequency was observed an strain severe combined immunodeficiency mice, expression methylated genes apparently lower than unmethylated EBV‐negative GC strains. Although over‐expression methyltransferases (...
Promoter hypermethylation of various tumor-related genes is extremely frequent in Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC). To investigate the significance promoter methylation EBVaGC, we focused on one important proteins carcinogenesis stomach, E-cadherin. Methylation-specific PCR analysis (MSP) was applied to surgically resected carcinomas, together with immunohistochemistry, PCR-based mutations and allelic loss, site-specific MSP E-cadherin gene. By MSP, nearly all...
CD70, a type II transmembrane glycoprotein, is member of the tumor necrosis factor (TNF) family that mediates interaction between B- and T-lymphocytes. CD70 has been shown to be expressed by malignant lymphoma, especially Hodgkin's disease, nasopharyngeal carcinoma, both which are frequently associated with Epstein-Barr virus (EBV). In this study, we investigated expression in epithelial cells various types thymic tumors its association EBV. Immunohistochemical was studied on frozen tissue....
Previous studies suggest that some S100 proteins are involved in the progression of certain types cancer. However, no comprehensive data is currently available on expression family genes lung adenocarcinomas. Oligonucleotide array, quantitative reverse transcription–polymerase chain reaction and western blot analyses adenocarcinoma cell lines bronchiolar epithelial cells (SAEC NHBE) revealed S100A2 S100A4 were most strikingly downregulated upregulated members family, respectively....
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized pathologically by the presence of ubiquitinated inclusions (NII) in neuronal cells. We demonstrate that NIIs both sporadic and familial NIID contained small ubiquitin modifier-1 (SUMO-1) SUMOylation substrates promyelocytic leukaemia protein (PML) histone deacetylase 4 (HDAC4). Both PML SUMO-1 are major components nuclear bodies (NBs), suggesting NIID, as well polyglutamine diseases, might...