A5022342891- Cancer-related molecular mechanisms research
- Immune cells in cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Caveolin-1 and cellular processes
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Circular RNAs in diseases
- Kruppel-like factors research
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Renal cell carcinoma treatment
- Digestive system and related health
Akita University
2016-2025
Kanazawa University
2023
Osaka Metropolitan University
2022
Queen Mary Hospital
2019
University of Hong Kong
2019
Seoul National University
2019
National Health Research Institutes
2019
Kyungpook National University Medical Center
2019
Chiayi Chang Gung Memorial Hospital
2019
Cellular Research (United States)
2017
Fifteen percent of lung cancer cases occur in never-smokers and show characteristics that are molecularly clinically distinct from those smokers. Epidermal growth factor receptor (EGFR) gene mutations, which correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), more frequent never-smoker cancers. In this study, microRNA (miRNA) expression profiling 28 identified aberrantly expressed miRNAs, were much fewer than cancers smokers included miRNAs previously (e.g.,...
l-Carnitine is an essential component of mitochondrial fatty acid β-oxidation and plays a pivotal role in the maturation spermatozoa within male reproductive tract. Epididymal plasma contains highest levels l-carnitine found human body, initiation sperm motility occurs parallel to increase epididymal lumen. Using specific carrier, epithelium secretes into lumen by active transport mechanism; however, structure-activity relationship comprising carnitine-permeation pathway poorly understood....
Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, discomfort or pain of unknown etiology. Based on cystoscopic findings, patients IC are classified as either Hunner-type/classic (HIC), presenting specific Hunner lesion, non-Hunner-type (NHIC), no but post-hydrodistension mucosal bleeding. Inflammatory cell infiltration, composed predominantly lymphocytes, plasma cells and epithelial denudation, has in the past been documented major pathological finding. However,...
This study determined whether expression levels of a panel biologically relevant microRNAs can be used as prognostic or predictive biomarkers in patients who participated the International Adjuvant Lung Cancer Trial (IALT), largest randomized conducted to date adjuvant chemotherapy with radically resected non-small cell lung carcinoma (NSCLC). Expression miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a was by quantitative real-time PCR formalin-fixed paraffin-embedded tumor specimens from...
c‐Met is often overexpressed in non‐small cell lung cancer, but it remains unsolved whether its overexpression leads to activation. We used an antibody specific phospho‐c‐Met (Tyr1235) investigate activation immunohistochemically 130 surgically resected adenocarcinomas. The expression of and hepatocyte growth factor (HGF) was also investigated. Phospho‐c‐Met positive 21.5% (28/130) cases. 74.6% cases (97/130) expressed at high levels 36.1% (47/130). HGF 31.5% (41/130). correlated with ( P =...
The gene for the human orthologue of mouse epiglycanin, a mucin expressed on mammary carcinoma TA3-Ha cells but not TA3-St cells, was identified by homology search to epiglycanin cDNA fragment representational difference analysis between and cells. open reading frame this cloned from cervical ME-180 It consists domain with 28 nonidentical tandem repeats 45 nucleotides each corresponding threonine/serine-rich peptide, stem domain, transmembrane cytoplasmic tail. FLAG sequence in K562 A...
MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs non-small-cell lung cancer (NSCLC), we mapped on autosomal chromosomes and selected 55 silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) determined expressions of miRNAs. Fourteen were decreased induced after 5-aza-CdR treatment. After a detailed analysis, found that mir-34b mir-126 by methylation. Mir-34b was its own...
Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but link has not been firmly established. We performed international pooled analysis cross-sectional (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in cancer and investigate viral presence according clinical demographic characteristics. HPV16/18 were most commonly detected, substantial variation between geographic regions. The...
Cancer-associated fibroblasts (CAFs) interact closely with cancer cells, supporting their growth and invasion. To investigate the role of microRNA-21 (miR-21) in lung adenocarcinoma, especially its CAF component, situ hybridisation was applied to samples from 89 invasive adenocarcinoma cases. MiR-21 expression observed both cells CAFs. When patients were stratified by expression, miR-21 levels CAFs (n = 9), but not 21), inversely correlated patient survival; miR-21high exhibited lower...
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping an additional 10,780 cases and 10,938 controls from Asia confirmed with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), overall risk, rs3817963 (6p21.3, BTNL2) which is...
Matrix metalloproteinases play a crucial role in tumour invasion and metastasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis colorectal carcinomas; however, its implication early invasive carcinomas not determined. This study was undertaken clarify the association of matrilysin expression clinicopathologic parameters carcinomas. 38 treated by local excision radical surgery were examined. Tumour budding evaluated as number dedifferentiation units along...
Angiotensin II blockade and spironolactone effectively reduces proteinuria in humans. To clarify the mechanisms of beneficial effect both aldosterone angiotensin II, we associated antagonist eplerenone to an angiotensin-converting enzyme inhibitor (ACEI) examined on renal transforming growth factor (TGF)-beta expression oxidative stress by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase Dahl salt-sensitive rat with heart failure (DSHF).Dahl salt-resistant control rats DSHF were...
Low-grade lung adenocarcinoma of fetal type, which is well characterized by its unique clinicopathologic and molecular features, recognized as a distinct variant cancer. In contrast, high-grade with lung-like morphology (HG-LAFM) has not been studied widely. To characterize this subset better, we analyzed 17 adenocarcinomas at least focal component resembling developing epithelium in the pseudoglandular phase lung. These rare (ca. 0.4%) carcinomas occurred predominantly elderly men heavy...
Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through and DNA damage response (DDR). examined the association between DDR with macrophage levels in inflammatory bowel disease (IBD). In vitro experiments tested ability of macrophages induce primary cells. Inflammation modulating microRNAs were identified colon tissue for further investigation.Quantitative immunohistochemistry protein expression by cell type....
Abstract Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease conducting a genome-wide association study, followed two validation studies, 3,173 Japanese patients with mutation-positive lung and 15,158 controls. Four loci, 5p15.33 ( TERT ), 6p21.3 BTNL2 3q28 TP63 ) 17q24.2 BPTF previously shown to be strongly associated overall Asians, were...
We systematically characterized gene expression, inflammation and neovascularization in patients with interstitial cystitis/bladder pain syndrome to obtain biological evidence supporting diagnosis classification.We sequenced RNA obtained from bladder mucosal biopsies of 33 3 subtypes syndrome, including Hunner lesions 12, no 11 but glomerulations neither nor 10, 9 controls. Differentially expressed genes each subtype were searched identify specific pathways candidate important for...
Abstract AT-rich interactive domain 1A ( ARID1A ) functions as a tumor suppressor and several therapeutic targets in -mutated cancers are under development. Here, we investigated the prognostic value of for gastric cancer its association with expression PD-L1 p53. was examined by immunohistochemistry negative detected 39 (19.5%) 200 cases test cohort 40 (18.2%) 220 validation cohort. Negative associated worse overall survival undifferentiated cases, particularly early-stage cases. 11 (50%)...
Epstein-Barr virus-positive gastric cancer [EBV (+) GC] is a distinct GC subtype with unique genetic and epigenetic aberrations. Here, we examined resected samples publicly available microarray data The Cancer Genome Atlas (TCGA) database to identify the mechanism underlying overexpression of PD-L1 in EBV GC. We found that high levels were caused by focal amplification CD274. By contrast, relatively expression tumor tissue infiltrating immune cells correlated CD8 lymphocyte infiltration...
In some tumors, a small number of cancer cells are scattered in large fibrotic stroma. Here, we demonstrate novel mechanism for expansion pro‐tumor fibroblasts via cancer‐associated fibroblast (CAF)‐mediated education normal (NFs). When NFs were incubated with conditioned medium from CAFs, the resulting CAF‐educated (CEFs) generated reactive oxygen species, which induced NF‐κB‐mediated expression inflammatory cytokines and extracellular matrix protein asporin (ASPN), while common CAF marker...