A5089607790- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- TGF-β signaling in diseases
- Kruppel-like factors research
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
Osaka Metropolitan University
2022-2024
Tokyo Metropolitan University
2023-2024
Maruho (Japan)
2024
Osaka City University
2014-2023
Molecular Oncology (United States)
2021-2023
Akita University
2022
Osaka Prefecture University
2020
Tohoku University
2018
Galaxy Biotech (United States)
2010
RIKEN BioResource Research Center
2009
Transforming growth factor (TGF)-beta plays a pivotal role in regulation of progression cancer through effects on tumor microenvironment as well cells. TGF-beta inhibitors have recently been shown to prevent the and metastasis certain cancers. However, there may be adverse caused by signaling inhibition, including induction cancers repression TGF-beta-mediated inhibition. Here, we present an application short-acting, small-molecule type I receptor (TbetaR-I) inhibitor at low dose treating...
The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this an important promoter cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in PI3K/Akt/mTOR gastric carcinoma have often been demonstrated. Many kinds molecular targeting therapies are currently undergoing clinical testing patients with solid...
The purpose of this study was to investigate the impact Controlling Nutritional Status (CONUT) score on survival compared with platelet lymphocyte ratio (PLR), neutrophil (NLR), and Glasgow Prognostic Score (GPS) in patients resectable thoracic esophageal squamous cell carcinoma (ESCC). One hundred eighty-five consecutive who underwent subtotal esophagectomy curative intent for ESCC were retrospectively reviewed. Time-dependent receiver operating characteristic curve analyses 3-year overall...
FGFR signaling is deregulated in many human cancers, and considered a valid target FGFR-deregulated tumors. Here, we examine the preclinical profile of futibatinib (TAS-120; 1-[(3S)-[4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3, 4-d] pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one), structurally novel, irreversible FGFR1-4 inhibitor. Among panel 296 kinases, selectively inhibited with IC50 values 1.4 to 3.7 nmol/L. Futibatinib covalently bound kinase domain, inhibiting...
We have identified a critical role for amplified FGFR2 in gastric cancer cell proliferation and survival. In panel of lines, fibroblast growth factor receptor 2 (FGFR2) was overexpressed tyrosine phosphorylated selectively FGFR2-amplified lines KatoIII, Snu16, OCUM-2M. kinase inhibition by specific small-molecule inhibitor resulted selective potent resulting arrest KatoIII cells prominent induction apoptosis both Snu16 OCUM-2M cells. also contained elevated phosphotyrosine EGFR, Her2, Erbb3,...
Peritoneal metastasis is the most frequent type of recurrence in patients with gastric cancer (GC) and associated poor prognosis. lavage cytology, used to evaluate risk peritoneal metastasis, has low sensitivity. Here, we assessed diagnostic potential exosomal miRNA profiles fluid for prediction dissemination GC. Total RNA was extracted from exosomes isolated six malignant ascites (MA) samples, 24 (PLF) culture supernatants (CM) two human carcinoma cell lines that differ their metastasis....
Persistent colonization of the gastric mucosa by Helicobacter pylori (Hp) elicits chronic inflammation and aberrant epithelial cell proliferation, which increases risk cancer. Here we examine ability microRNAs to modulate proliferation in response persistent Hp infection find that epigenetic silencing miR-210 plays a key role disease progression. Importantly, DNA methylation gene is increased Hp-positive human biopsies as compared with Hp-negative controls. Moreover, cells promotes...
Extracellular vesicles (EV) from cancer-associated fibroblasts (CAF) are composed of diverse payloads. Although CAFs impact the aggressive characteristics gastric cancer cells, contribution CAF-EV to progression has not been elucidated. Here, we investigated molecular mechanism changes in induced by CAF-EV. CAF abundance tissues was associated with poor prognosis patients receiving chemotherapy. Moreover, tubular network formation and drug resistance cells extracellular matrix (ECM)....
Cancer-associated fibroblasts (CAFs) have recently been implicated in tumor growth and metastasis gastric cancer. Cancer stem cells (CSCs) proposed to an important role cancer progression. The aim of this study was clarify the effect CAFs on CSCs characteristics carcinoma. Scirrhous cell lines, OCUM-12 OCUM-2MD3, non-scirrhous MKN-45 MKN-74, were used. OCUM-12/side population (SP) OCUM-2MD3/SP sorted by flow cytometry as CSC-rich from parent cells. CaF-37 established tumoral specimens CAFs....
Cancer-associated fibroblasts (CAFs), one of the major components a tumour microenvironment, comprise heterogeneous populations involved in progression. However, it remains obscure how CAF heterogeneity is governed by cancer cells. Here, we show that extracellular vesicles (EVs) induce series chemokines activated and contribute to formation heterogeneity. In xenograft model diffuse-type gastric cancer, showed two distinct fibroblast subpopulations with alpha-smooth muscle actin (α-SMA)...
Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness colorectal cancers (CRC), driving progression metastasis. Targetable molecules in tumor microenvironment (TME) need to be identified improve outcome CRC patients with this aggressive phenotype. This study reports a positive link between high thrombospondin-1 (THBS1) expression characteristics, immunosuppression, unfavorable prognosis. Bone marrow-derived monocyte-like...