A5016513561- Photoreceptor and optogenetics research
- Pancreatic and Hepatic Oncology Research
- Neurobiology and Insect Physiology Research
- Marine Ecology and Invasive Species
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- RNA modifications and cancer
- Cephalopods and Marine Biology
- Receptor Mechanisms and Signaling
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Developmental Biology and Gene Regulation
- Spectroscopy and Quantum Chemical Studies
- Cancer Cells and Metastasis
- Photochromic and Fluorescence Chemistry
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
Oregon Health & Science University
2021-2025
University of Portland
2024
Kyoto University
1971-2023
Weatherford College
2021
Kindai University
2020
University of Hyogo
2004-2017
Japanese Red Cross Society Wakayama Medical Center
2013
Hyogo University
2013
Tokushima Bunri University
2007-2012
NTT (Japan)
2012
The extracellular matrix protein laminin 511 is an autoantigen involved in the pathophysiology of autoimmune pancreatitis.
<h3>Objective</h3> IgG4-related disease (IgG4-RD) is a systemic characterised by elevated serum IgG4 and IgG4-positive lymphoplasmacytic infiltration in the affected tissues. The pathogenic role of IgGs, including IgG4, patients with IgG4-RD, however, unknown. <h3>Design</h3> We examined activity circulating IgGs IgG4-RD injecting their into neonatal male Balb/c mice. Binding patient to pancreatic tissue was also analysed an ex vivo mouse organ culture model samples from autoimmune...
Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness colorectal cancers (CRC), driving progression metastasis. Targetable molecules in tumor microenvironment (TME) need to be identified improve outcome CRC patients with this aggressive phenotype. This study reports a positive link between high thrombospondin-1 (THBS1) expression characteristics, immunosuppression, unfavorable prognosis. Bone marrow-derived monocyte-like...
The primary structure of rhodopsin from the octopus Paroctopus defleini has been determined by parallel analysis protein and corresponding cDNA. amino acid sequence is most similar to recently cloned Drosophila opsins. Similarities bovine human opsins are also evident. transmembrane topology discussed.
The upconversion emission intensities of Er3+ ion around 550 and 660 nm in fluorozirconate glasses were measured under 800 excitation. Though energy transfer processes played an important role mechanism at high concentration ErF3, those have not been treated quantitatively. rates calculated from the optical parameters assuming some distribution ions. We by using rate equations. It was found that dependence on ErF3 could be reproducible principal evaluated.
Abstract Glutamate is a major neurotransmitter in the excitatory synapses of both vertebrate and invertebrate nervous systems involved many neural processes including photo‐, mechano‐, chemosensations, development, motor control, learning, memory. We identified characterized gene ( Ci ‐ VGLUT ) encoding member vesicular glutamate transporter subfamily, specific marker glutamatergic neurons, ascidian Ciona intestinalis . The expressed adhesive organ, epidermal brain vesicle, but not visceral...
Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation intraductal mucinous neoplasm (IPMN) and IPMN-derived PDA originated from cells. However, role intraepithelial neoplasia–derived (PanIN-derived) acinar cells remains elusive. Here, we found exclusive elimination Brg1 Ptf1a-CreER; KrasG12D; Brg1fl/fl mice impaired acinar-to-ductal metaplasia (ADM) PanIN...
The anterior sensory vesicle of ascidian larvae contains a single large in which lie two distinct types pigment cells, and posterior. ultrastructure these cells suggests that the cell is an otolith, presumably used for gravity detection, posterior ocellus, photoreception. However, there no direct experimental evidence this assignment function. Upward swimming behaviour occurring during initial period larval life was examined before after laser ablation cells. Posterior cell-ablated retained...
We consider the problem of color regulation in visual pigments for both bovine rhodopsin (lambda max = 500 nm) and octopus 475 nm). Both have 11-cis-retinal 379 nm, ethanol) as their chromophore. These rhodopsins were bleached native membranes, opsins regenerated with natural artificial chromophores. 9-cis- isomers, but opsin was additionally 13-cis all-trans isomers. Titration gave an extinction coefficient 27,000 +/- 3000 M-1 cm-1 at nm. The absorption maxima formed by regenerating 11-cis...
Journal Article Kinetic Studies on Hydrogenase: Parahydrogen-Orthohydrogen Conversion and Hydrogen-Deuterium Exchange Reactions Get access Tatsuhiko YAGI, YAGI Department of Chemistry, Shizuoka UniversityShizuoka 420 Search for other works by this author on: Oxford Academic PubMed Google Scholar Motoyuki TSUDA, TSUDA *Institute Solid State Physics, the University TokyoTokyo 106 Hiroo INOKUCHI The Biochemistry, Volume 73, Issue 5, May 1973, Pages 1069–1081,...
Abstract The vertebrate‐type opsin, Ci‐opsin1, is localized in the outer segments of photoreceptor cells larvae ascidian Ciona intestinalis . absorption spectrum photopigment reconstituted from Ci‐opsin1 and 11‐ cis ‐retinal suggested that responsible for photic behavior larvae. structure function Ci‐opsin1‐positive were examined by immunohistochemistry, confocal microscopy, electron laser ablation, behavioral analysis. have three morphologically distinct groups brain vesicle. Group I group...
The ascidian larva is an excellent model for studies of the functional organization and neuronal circuits chordates due to its remarkably simple central nervous system (CNS), comprised about 100 neurons. To date, however, identities various neurons in larva, particularly their neurotransmitter phenotypes, are not well established. Acetylcholine, GABA, glycine critical neurotransmitters locomotion many animals. We visualized putative cholinergic GABAergic/glycinergic by immunofluorescent...
Gonadotropin-releasing hormone (GnRH) is a neuroendocrine peptide that plays central role in the vertebrate hypothalamo-pituitary axis. The roles of GnRH control reproductive functions have been established, while its non-reproductive function has suggested but less well understood. Here we show tunicate Ciona intestinalis larval stage prominent system spanning entire length nervous system. Tunicate receptors are phylogenetically closest to receptors, yet functional analysis revealed these...