A5076214400- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Chromatin Dynamics
- Wnt/β-catenin signaling in development and cancer
- Chromatin Remodeling and Cancer
- Abdominal vascular conditions and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Viral-associated cancers and disorders
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Mechanisms of cancer metastasis
- Hedgehog Signaling Pathway Studies
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Pneumothorax, Barotrauma, Emphysema
- Gastrointestinal disorders and treatments
- Abdominal Surgery and Complications
- Hippo pathway signaling and YAP/TAZ
- Cancer Immunotherapy and Biomarkers
Kyoto University
2020-2024
Hyogo Prefectural Amagasaki General Medical Center
2018
Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness colorectal cancers (CRC), driving progression metastasis. Targetable molecules in tumor microenvironment (TME) need to be identified improve outcome CRC patients with this aggressive phenotype. This study reports a positive link between high thrombospondin-1 (THBS1) expression characteristics, immunosuppression, unfavorable prognosis. Bone marrow-derived monocyte-like...
Abstract Background Pancreatic cancer is often diagnosed at advanced stages, and early-stage diagnosis of pancreatic difficult because nonspecific symptoms lack available biomarkers. Methods We performed comprehensive serum miRNA sequencing 212 patient samples from 14 hospitals 213 non-cancerous healthy control samples. randomly classified the into two cohorts: a training cohort ( N = 185) validation 240). created ensemble models that combined automated machine learning with 100 highly...
RECK is downregulated in various human cancers; however, how inactivation affects carcinogenesis remains unclear. We addressed this issue a pancreatic ductal adenocarcinoma (PDAC) mouse model and found that Reck deletion dramatically augmented the spontaneous development of PDAC with mesenchymal phenotype, which was accompanied by increased liver metastases decreased survival. Lineage tracing revealed induced epithelial-mesenchymal transition (EMT) cells, giving rise to inflammatory...
Biliary tract cancer (BTC) has poor prognosis. The Notch receptor is aberrantly expressed in extrahepatic cholangiocarcinoma (eCCA). However, the role of signaling initiation and progression eCCA gallbladder (GB) remains unknown. Therefore, we investigated functional during tumorigenesis bile duct (EHBD) GB. Activation oncogenic Kras resulted development biliary intraepithelial neoplasia (BilINs) EHBD GB, which were premalignant lesions that progressed to adenocarcinoma mice. expression...
Abstract Biliary cancer has long been known to carry a poor prognosis, yet the molecular pathogenesis of carcinoma extrahepatic biliary system and its precursor lesions remains elusive. Here we investigated role Kras canonical Wnt pathways in tumorigenesis bile duct (EHBD) gall bladder (GB). In mice, concurrent activation induced neoplasms that resembled human intracholecystic papillary-tubular neoplasm (ICPN) intraepithelial neoplasia (BilIN), putative precursors invasive cancer. At low...
Tumor cells capable of self-renewal and continuous production progeny are called tumor stem (TSCs) considered to be potential therapeutic targets. However, the mechanisms underlying survival function TSCs not fully understood. We previously reported that chromatin remodeling regulator Brg1 is essential for intestinal in mice Dclk1 an TSC marker. In this study, we investigated role Dclk1+ maintenance tumors mice. Specific ablation reduced ApcMin mice, maintained reduction tumors. Lineage...
Tumor stem cells (TSCs), capable of self-renewal and continuous production progeny cells, could be potential therapeutic targets. We have recently reported that chromatin remodeling regulator Brg1 is required for maintenance murine intestinal TSCs stemness feature human colorectal cancer (CRC) by inhibiting apoptosis. However, it still unclear how BRG1 suppression changes the underlying intracellular mechanisms CRC cells. found resulted in upregulation JNK signaling pathway TSCs....
<div>Abstract<p>Biliary cancer has long been known to carry a poor prognosis, yet the molecular pathogenesis of carcinoma extrahepatic biliary system and its precursor lesions remains elusive. Here we investigated role Kras canonical Wnt pathways in tumorigenesis bile duct (EHBD) gall bladder (GB). In mice, concurrent activation induced neoplasms that resembled human intracholecystic papillary-tubular neoplasm (ICPN) intraepithelial neoplasia (BilIN), putative precursors invasive...
Supplementary Data from Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
Supplementary Figure from Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
Supplementary Data from Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
Supplementary Figure from Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
<div>Abstract<p>Biliary cancer has long been known to carry a poor prognosis, yet the molecular pathogenesis of carcinoma extrahepatic biliary system and its precursor lesions remains elusive. Here we investigated role Kras canonical Wnt pathways in tumorigenesis bile duct (EHBD) gall bladder (GB). In mice, concurrent activation induced neoplasms that resembled human intracholecystic papillary-tubular neoplasm (ICPN) intraepithelial neoplasia (BilIN), putative precursors invasive...
A 59-year-old man was admitted to our hospital for hematemesis. hematoma found in the posterior wall of stomach, but source bleeding not identified. One month later, contrast-enhanced computed tomography revealed a pseudoaneurysm short gastric artery. Embolization difficult due vessel tortuosity. Usage distal access catheter improved stability and enabled successful embolization. We consider be useful embolization an aneurysm beyond tortuous