A5101867380- Lung Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Myasthenia Gravis and Thymoma
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atrial Fibrillation Management and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Congenital Diaphragmatic Hernia Studies
- Gastric Cancer Management and Outcomes
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Metastasis and carcinoma case studies
- Trauma Management and Diagnosis
- RNA modifications and cancer
- Cardiac Arrest and Resuscitation
The University of Tokyo
2016-2025
Tokyo Medical and Dental University Hospital
2019-2025
Toshima Hospital
2023-2025
Osaka Institute of Technology
2021-2024
University of Tokyo Hospital
2015-2024
Japanese Red Cross Medical Center
2024
Tokyo Yamate Medical Center
2024
Gunma University
2010-2023
New York Proton Center
2023
English Heritage
2023
In plants, osmotic stress-responsive transcriptional regulation depends mainly on two major classes of cis-acting elements found in the promoter regions stress-inducible genes: ABA-responsive (ABREs) and dehydration-responsive (DREs). ABRE has been shown to perceive ABA-mediated stress signals, whereas DRE is known be involved an ABA-independent pathway. Previously, we reported that transcription factor DRE-BINDING PROTEIN 2A (DREB2A) regulates DRE-mediated target genes under conditions...
Arabidopsis thaliana DEHYDRATION-RESPONSIVE ELEMENT BINDING PROTEIN2A (DREB2A) functions as a transcriptional activator that increases tolerance to osmotic and heat stresses; however, its expression also leads growth retardation reduced reproduction. To avoid these adverse effects, the of DREB2A is predicted be tightly regulated. We identified short promoter region represses under nonstress conditions. Yeast one-hybrid screening for interacting factors GROWTH-REGULATING FACTOR7 (GRF7). GRF7...
Erythromycin (EM) and its 14-member macrolide analogues have attracted attention for effectiveness in a variety of airway diseases, including diffuse panbronchiolitis (DPB), sinobronchial syndrome, chronic sinusitis. However, mechanisms action remain unelucidated. We evaluated the effects several antibiotics on IL-8 expression by normal transformed human bronchial epithelial cells, an important source this potent chemokine involved cell recruitment into airways. EM clarithromycin (CAM)...
Objectives: Human γδ T lymphocytes can recognise and kill non-small-cell lung cancer cells by Vγ9Vδ2 T-cell receptor and/or NKG2D. We have established large-scale ex vivo expansion of zoledronate interleukin-2. This pilot feasibility study evaluates the safety potential anti-tumour effects activated autologous administered intravenously to patients. Methods: Patients who had measurable foci recurrent were registered undergo immunotherapy, designed as a one-way, open, clinical research, after...
Human γδ T cells can recognize and kill non-small cell lung cancer (NSCLC) using the Vγ9Vδ2 T-cell receptor and/or NKG2D. We have established clinical grade large-scale ex vivo expansion of from peripheral blood mononuclear by culturing with zoledronate interleukin-2 (IL-2). A phase I study was conducted to evaluate safety potential antitumor effects re-infusing expanded in patients recurrent or advanced NSCLC. Patient's were stimulated (5 μM) IL-2 (1000 IU/mL) for 14 days. Harvested cells,...
We aimed to identify prognostic factors after pulmonary metastasectomy for colorectal cancer and propose the clinical application of them. Furthermore, we endeavored provide a rationale metastasesectomy.Several have been proposed, but them remains unclear. Moreover, there is no theoretical evidence that indicated cancer.We retrospectively analyzed 1030 patients who underwent from 1990 2008. Prognostic were identified relationship recurrent sites resection tumor size was assessed.Overall...
YAP 1 , the main Hippo pathway effector, is a potent oncogene and overexpressed in non‐small‐cell lung cancer ( NSCLC ); however, expression pattern small‐cell SCLC ) has not yet been elucidated detail. We report that loss of special feature high‐grade neuroendocrine tumors. A hierarchical cluster analysis 15 tumor cell lines containing 14 depended on genes molecules markers clearly classified these into two groups: ‐negative marker‐positive group n = 11), ‐positive marker‐negative 4). Among...
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of in cohort Japanese individuals collected during initial waves pandemic, with 3,289 unaffected controls. We identified variant on chromosome 5 at 5q35 (rs60200309-A), close to dedicator cytokinesis 2 gene (DOCK2), which was associated patients less than 65 years age. This risk allele prevalent East Asian but rare...
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 disease 2019 (COVID-19) patients 75 healthy controls Japanese ancestry with host genetic data. COVID-19 showed a low fraction nonclassical monocytes (ncMono). report downregulated transitions classical to ncMono reduced CXCL10 expression...
c‐Met is often overexpressed in non‐small cell lung cancer, but it remains unsolved whether its overexpression leads to activation. We used an antibody specific phospho‐c‐Met (Tyr1235) investigate activation immunohistochemically 130 surgically resected adenocarcinomas. The expression of and hepatocyte growth factor (HGF) was also investigated. Phospho‐c‐Met positive 21.5% (28/130) cases. 74.6% cases (97/130) expressed at high levels 36.1% (47/130). HGF 31.5% (41/130). correlated with ( P =...
MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs non-small-cell lung cancer (NSCLC), we mapped on autosomal chromosomes and selected 55 silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) determined expressions of miRNAs. Fourteen were decreased induced after 5-aza-CdR treatment. After a detailed analysis, found that mir-34b mir-126 by methylation. Mir-34b was its own...
The purpose of this investigation was to compare the outcome percutaneous radiofrequency thermal ablation therapy (PRFA) with surgical resection (SR) in treatment single and small hepatocellular carcinoma (HCC). We conducted a retrospective cohort study on 231 naive patients HCC ≤ 3 cm who had received either curative PRFA (162 patients) or SR (69 patients). All were regularly followed up after at our department blood radiologic tests. 1-, 3- 5-year overall survival rates 95.4%, 79.6% 63.1%,...
Stroke can be a life-threatening complication of atrial fibrillation (AF) catheter ablation. Uninterrupted warfarin treatment contributes to minimizing the risk stroke complications.This was prospective, open-label, randomized, multicenter study assessing safety and efficacy apixaban for prevention cerebral thromboembolism complicating AF Two hundred patients with drug-resistant were equally assigned take either (5 mg or 2.5 twice daily) (target international normalized ratio, 2-3) at least...
Paroxysmal atrial fibrillation (AF) is primarily triggered by pulmonary veins (PVs). However, non-PV AF foci may also trigger AF.We examined 207 patients (mean age, 62 ± 11 years; 166 men) who underwent a second catheter ablation (CA) and evaluated the clinical significance of on outcomes.Electrical reconnections between PVs left atrium (LA) were observed in 162 (78.3%). Non-PV identified 95 (45.9%, 60 with successfully ablated 35 unmappable foci). During median follow-up period 22.7 months,...