A5089890846- Health Systems, Economic Evaluations, Quality of Life
- Migraine and Headache Studies
- Statistical Methods in Clinical Trials
- Musculoskeletal pain and rehabilitation
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Optimal Experimental Design Methods
- Cardiovascular Syncope and Autonomic Disorders
- Patient Satisfaction in Healthcare
- Pharmaceutical Economics and Policy
- Respiratory Support and Mechanisms
- Cardiac Arrhythmias and Treatments
- Delphi Technique in Research
- Psychosomatic Disorders and Their Treatments
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Pain Management and Placebo Effect
- Head and Neck Surgical Oncology
University Hospitals Coventry and Warwickshire NHS Trust
2023-2025
University of Warwick
2015-2024
University Hospital Coventry
2024
Pennine Acute Hospitals NHS Trust
2021
Fairfield General Hospital
2021
National Institute for Health Research
2014-2016
University of Southampton
2016
NIHR Evaluation Trials and Studies Coordinating Centre
2016
National Cancer Centre Singapore
2006-2010
National University of Singapore
2010
<h3>Importance</h3> Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness safety of these noninvasive strategies. <h3>Objective</h3> To determine whether either CPAP or HFNO, compared conventional therapy, improves clinical outcomes hospitalized COVID-19–related failure. <h3>Design, Setting, Participants</h3> A parallel group,...
Abstract Background There is a lack of international consensus regarding the prescription high-intensity interval training (HIIT) for people with coronary artery disease (CAD) attending cardiac rehabilitation (CR). Aims To assess clinical effectiveness and safety low-volume HIIT compared moderate-intensity steady-state (MISS) exercise CAD. Methods results We conducted multi-centre RCT, recruiting 382 patients from 6 outpatient CR centres. Participants were randomized to twice-weekly (n =...
Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but link has not been firmly established. We performed international pooled analysis cross-sectional (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in cancer and investigate viral presence according clinical demographic characteristics. HPV16/18 were most commonly detected, substantial variation between geographic regions. The...
ABSTRACT Background Both continuous positive airway pressure (CPAP) and high-flow nasal oxygenation (HFNO) have been recommended for acute respiratory failure in COVID-19. However, uncertainty exists regarding effectiveness safety. Methods In the Recovery-Respiratory Support multi-center, three-arm, open-label, adaptive, randomized controlled trial, adult hospitalized patients with due to COVID-19, deemed suitable treatment escalation, were randomly assigned receive CPAP, HFNO, or...
This study attempted to evaluate the usefulness of International Prognostic Index (IPI) as a prognostic model in patients treated with R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone) chemotherapy. We compared 279 DLBCL. Among them, 183 received CHOP while 96 R-CHOP. Results showed that there were no statistically significant differences between two groups terms both patient lymphoma characteristics. The estimated 2-year survival was significantly higher among...
The aim of the study was to assess feasibility conducting a definitive multicentre randomised controlled trial (RCT) testing an online exercise rehabilitation and behavioural/motivational support intervention for people with postural tachycardia syndrome (PoTS). Feasibility RCT. Two secondary care centres. Adults aged 18 60 years PoTS. Exclusions were serious mental health/cognitive problem preventing safe participation; currently undertaking physical activity equivalent Chief Medical...
Nasopharyngeal carcinoma (NPC) is a disease that highly responsive to various chemotherapeutic agents. In the metastatic setting, 2-drug combination chemotherapy generally provides response rate of 55% 75%, and median survival 10 12 months. The objective current study was assess efficacy 3-drug followed by maintenance treatment in patients with NPC.Patients NPC were treated gemcitabine at dose 1,000 mg/m(2), paclitaxel 70 carboplatin an area under concentration-time-curve (AUC) 2.5 on Days 1...
Patients with breast cancer often receive emetogenic anthracycline-based chemotherapy as part of their treatment. Chemotherapy-induced nausea and vomiting (CINV) has been commonly reported one the distressing adverse effects among patients cancer. Despite advent newer antiemetics better understanding CINV pathophysiology, total eradication yet to be achieved.To assess incidence in who have are receiving adjuvant doxorubicin cyclophosphamide (AC) bolus chemotherapy, ascertain patients' risk...
PURPOSE: We evaluated the clinical benefit of an allogeneic melanoma cell lysate (MCL)-pulsed autologous dendritic (DC) vaccine in advanced colorectal cancer patients expressing at least one six MAGE-A antigens overexpressed by line source lysate. EXPERIMENTAL DESIGN: DCs were cultured from peripheral blood mononuclear cells (PBMC), pulsed with MCL, and matured using cytokines that achieved high CD83- CCR7-expressing DCs. Each patient received up to 10 intradermal vaccinations (3-5 x 10(6)...
Abstract Aim: We aimed to compare the frequencies, clinical characteristics, and prognostic factors of peripheral T‐cell lymphoma (PTCL) vs. extra‐nodal natural killer (NK)/T‐cell characterize subtypes NK/T‐cell lymphoma. Methods: reviewed 97 consecutive patients with PTCL NKT from 2000 2006. During this period, a total 780 malignant lymphomas were treated in our center. The diagnostic criteria used based on WHO classification system lymphomas. Results: Extra‐nodal‐NK/T‐cell comprised 5.0%...
Clinical trials are typically designed using the classical frequentist framework to constrain type I and II error rates. Sample sizes required in such designs range from hundreds thousands of patients which can be challenging for rare diseases. It has been shown that disease have smaller sample than non-rare trials. Indeed some orphan drugs were approved by European Medicines Agency based on studies with as few 12 patients. However, supporting marketing authorisation included several hundred...
Retropharyngeal lymph node (RLN) staging in nasopharyngeal carcinoma (NPC) can be controversial.We retrospectively reviewed all patients with T(2-4), N(0-1) NPC treated between 1992 and 1994 to examine if RLN metastasis resulted an increased incidence of distant metastases.Of the 667 NPC, 395 had disease, 140 N(0), 255 N(1). All CT scans were radiotherapy. Median follow-up was 8.3 years. Seventy-four percent showed undifferentiated histology. In this cohort, 187 (47%) metastases....
The problem of choosing a sample size for clinical trial is very common one. In some settings, such as rare diseases or other small populations, the large sizes usually associated with standard frequentist approach may be infeasible, suggesting that chosen should reflect population under consideration. Incorporation possible in decision‐theoretic either explicitly by assuming fixed and known, implicitly through geometric discounting gain from future patients reflecting expected size. This...
Low back pain is a common and disabling condition leading to large health service societal costs. Although there are several treatment options for little known about how improve patient choice in selection. The purpose of this study was pilot decision support package help people choose between low treatments. This single-centred cluster randomised controlled trial conducted community physiotherapy service. We included adults with non-specific referred physiotherapy. Intervention participants...
Background There is good evidence that therapist-delivered interventions have modest beneficial effects for people with low back pain (LBP). Identification of subgroups LBP who may benefit from these different treatment approaches an important research priority. Aim and objectives To improve the clinical effectiveness cost-effectiveness by providing patients, their advisors health-service purchasers better information about which participants are most likely to choices. Our were synthesise...
Chronic headache disorders are a major cause of pain and disability. Education supportive self-management approaches could reduce the burden We tested effectiveness group educational program for people living with chronic headaches.This was pragmatic randomized controlled trial. Participants were aged 18 years or older migraine tension-type headache, without medication overuse headache. primarily recruited from general practices. assigned to either 2-day education program, one-to-one nurse...
Atrial fibrillation (AF) is associated with significant morbidity/mortality. AF-ablation an increasingly used treatment. Currently, first-time success 40-80% at 1-year, depending on individual factors. There growing evidence for improved outcomes through management of AF risk-factors/comorbidities via patient education/exercise-rehabilitation. are no studies assessing combined prehabilitation/rehabilitation in this cohort. The aim randomised controlled trial to assess efficacy comprehensive...
The efficacy of acupuncture in smoking cessation, and its effect on the urge to smoke are unclear. We evaluated a standardized protocol transcutaneous electric acupoint stimulations (TEAS) alleviating smoke. Ninety‐eight smokers were recruited two double‐blind studies. Participants abstained from for 26 h, randomized receive TEAS alternating between 2 100 Hz at four acupoints (LI4 PC8, PC6 TE5) different intensities (10, 5, Intermittent 5 or 0 mA). was assessed by Questionnaire Smoking Urges...