A5036351512- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Global Cancer Incidence and Screening
- Parathyroid Disorders and Treatments
- Cancer Risks and Factors
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Treatments and Studies
- Breast Lesions and Carcinomas
- Epigenetics and DNA Methylation
- Cancer and Skin Lesions
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- SARS-CoV-2 detection and testing
- Radiomics and Machine Learning in Medical Imaging
National University Hospital
2013-2025
Southwest University
2025
Hangzhou Dianzi University
2025
National University Health System
2015-2025
Changchun Institute of Optics, Fine Mechanics and Physics
2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Advanced Optical Systems (United States)
2025
Kunming University of Science and Technology
2023-2024
Beihang University
2024
ABSTRACT Background There are reports about the changing epidemiology of tongue squamous cell carcinoma (SCC), with recent indicating an increasing incidence in young women. Methods Data on incident cases SCC were collected from cancer registries worldwide. Results a total 22 and 89,212 worldwide included. Most areas experienced increase ranging 0.4% to 3.3% per year. was significant difference between sexes 11 registries. In 14 studied, higher group subjects <45 years old than those ≥45...
This study aimed to apply the International mRCC Database Consortium (IMDC) prognostic model in metastatic non-clear cell renal carcinoma (nccRCC). In addition, survival outcome of nccRCC patients was characterized.Data on 2215 (1963 with clear-cell RCC [ccRCC] and 252 nccRCC) treated first-line VEGF- mTOR-targeted therapies were collected from IMDC. Time treatment failure (TTF) overall (OS) compared groups favorable, intermediate, poor prognoses according IMDC criteriaThe median OS entire...
Abstract We aimed to test the sensitivity of naso-oropharyngeal saliva and self-administered nasal (SN) swab compared nasopharyngeal (NP) for COVID-19 testing in a large cohort migrant workers Singapore. also tested utility next-generation sequencing (NGS) diagnosis COVID-19. Saliva, NP SN swabs were collected from subjects who presented with acute respiratory infection, their asymptomatic roommates, prior confirmed cases undergoing isolation at community care facility June 2020. All samples...
Abstract Purpose: A reliable method for diagnosing parathyroid carcinoma has remained elusive over the years, resulting in its under-recognition and suboptimal therapy. Obtaining an accurate diagnosis become even more pressing matter with recent evidence that germline HRPT2 gene mutations are found patients apparently sporadic carcinoma. There is a high prevalence of biallelic inactivation We hypothesize loss parafibromin, protein product gene, would distinguish from benign tissue....
Aim To define a predictive model for clinical behaviour of breast phyllodes tumours (PT) using histological parameters and surgical margin status. Methods Cases PT diagnosed in the Department Pathology Singapore General Hospital between January 1992 December 2010 were stratified into benign, borderline malignant grades based on combination (stromal atypia, hypercellularity, mitoses, overgrowth nature tumour borders). Surgical status was assessed. Clinical follow-up biostatistical modelling...
A population of cell clusters circulating in cancer patients consist tumor-derived endothelial cells reflecting features the tumor vasculature.
Abstract Quantification of Epstein-Barr virus (EBV) cell-free DNA (cfDNA) is commonly used in clinical settings as a circulating biomarker nasopharyngeal carcinoma (NPC), but there has been no comparison with tumour cells (CTCs). Our study aims to compare the performance CTC enumeration against EBV cfDNA quantitation through digital PCR (dPCR) and quantitative PCR. 74 plasma samples from 46 NPC patients at baseline one month after radiotherapy or without concurrent chemotherapy were...
Although a few nanomedicines have been approved for clinical use in cancer treatment, that recognizes improved patient safety through targeted delivery, their efficacy over conventional drugs has remained marginal. One of the typical drawbacks nanocarriers therapy is low drug-loading capacity leads to insufficient and requires an increase dosage and/or frequency administration, which turn increases carrier toxicity. In contrast, elevating would cause risk nanocarrier instability, resulting...
Summary Objective Parathyroid carcinoma remains difficult to diagnose. Recently, it has been shown that mutations in the HRPT2 gene (encoding parafibromin) are associated with development of parathyroid carcinoma. Although MEN1 is not typically thought be involved formation, may an extremely rare feature multiple endocrine neoplasia type 1 (MEN1) syndrome. We recently concluded loss heterozygosity (LOH) present a relatively large number carcinomas, often combination LOH at locus. The aim...
Chromophobe renal cell carcinoma (chRCC) and oncocytoma are two distinct but closely related entities with strong morphologic genetic similarities. While chRCC is a malignant tumor, usually regarded as benign entity. The overlapping characteristics best explained by common cellular origin, the biologic differences between therefore of considerable interest in terms carcinogenesis, diagnosis clinical management. Previous studies have been relatively limited examining chromophobe RCC. Gene...
Surgery is the primary curative option in patients with hepatocellular carcinoma (HCC). Current prognostic models for HCC are developed on datasets of primarily advanced cancer, and may be less relevant to resectable HCC. We a postoperative nomogram, Singapore Liver Cancer Recurrence (SLICER) Score, predict outcomes who have undergone surgical resection.Records 544 consecutive undergoing first-line surgery one institution from 1992-2007 were reviewed, 405 local selected analysis. Freedom...
Abstract Parathyroid tumors are heterogeneous, and diagnosis is often difficult using histologic clinical features. We have undertaken expression profiling of 53 hereditary sporadic parathyroid to better define the molecular genetics tumors. A class discovery approach identified three distinct groups: (1) predominantly hyperplasia cluster, (2) HRPT2/carcinoma cluster consisting carcinomas benign malignant from Hyperparathyroidism-Jaw Tumor Syndrome patients, (3) adenoma mainly primary MEN 1...
This study attempted to evaluate the usefulness of International Prognostic Index (IPI) as a prognostic model in patients treated with R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone) chemotherapy. We compared 279 DLBCL. Among them, 183 received CHOP while 96 R-CHOP. Results showed that there were no statistically significant differences between two groups terms both patient lymphoma characteristics. The estimated 2-year survival was significantly higher among...
Abstract BACKGROUND. The majority of metastatic renal cell carcinoma (mRCC) clinical trials that examined targeted agents used progression‐free survival (PFS) as the primary endpoint. Whether PFS can be a predictor overall (OS) is unknown. METHODS. Patients from 12 cancer centers who received therapy for mRCC were identified. Landmark analyses progression at 3 months and 6 after drug initiation performed to minimize lead‐time bias. A proportional hazards model was assess utility predicting...
Abstract Idiosyncratic drug-induced hepatotoxicity is a major cause of liver damage and drug pipeline failure, difficult to study as patient-specific features are not readily incorporated in traditional testing approaches using population pooled cell sources. Here we demonstrate the use hepatocyte-like cells (HLCs) derived from induced pluripotent stem for modeling idiosyncratic pazopanib (PZ), tyrosine kinase inhibitor associated with significant unknown mechanistic basis. In vitro...
Genetic testing for germline mutations in breast cancer predisposition genes can potentially identify individuals at a high risk of developing and/or ovarian cancer. There is paucity such mutational information Asians. Panel 25 susceptibility and BRCA1/2 deletion/duplication analysis was performed 220 Asian patients or their family members referred genetics assessment. All participants had least one high-risk feature: having history first- second-degree relatives; the same individual...