A5084084351- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Oral health in cancer treatment
- Effects of Radiation Exposure
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Ear and Head Tumors
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Occupational and environmental lung diseases
- Polyomavirus and related diseases
National Cancer Centre Singapore
2014-2025
Duke-NUS Medical School
2016-2023
National Cancer Centre Japan
2019
Queen Elizabeth Hospital
2017
St Thomas' Hospital
2016
King's College London
2016
Guy's and St Thomas' NHS Foundation Trust
2016
National University of Singapore
2005
Hospital of the University of Pennsylvania
1987
Fox Chase Cancer Center
1987
The Intergroup 00-99 Trial for nasopharyngeal cancer (NPC) showed a benefit of adding chemotherapy to radiotherapy. However, there were controversies regarding the applicability results patients in endemic regions. This study aims confirm findings and its with NPC.Between September 1997 May 2003, 221 randomly assigned receive radiotherapy (RT) alone (n = 110) or chemoradiotherapy (CRT; n 111). Patients both arms received 70 Gy 7 weeks using standard RT portals techniques. on CRT concurrent...
Abstract Quantification of Epstein-Barr virus (EBV) cell-free DNA (cfDNA) is commonly used in clinical settings as a circulating biomarker nasopharyngeal carcinoma (NPC), but there has been no comparison with tumour cells (CTCs). Our study aims to compare the performance CTC enumeration against EBV cfDNA quantitation through digital PCR (dPCR) and quantitative PCR. 74 plasma samples from 46 NPC patients at baseline one month after radiotherapy or without concurrent chemotherapy were...
Purpose To investigate for a prognostic index (PI) to personalize recommendations salvage intensity-modulated radiotherapy (IMRT) in patients with locally recurrent nasopharyngeal carcinoma (lrNPC). Methods Patients lrNPC from two academic institutions (Sun Yat-Sen University Cancer Center [SYSUCC-A; n = 251 (training cohort)] and National Centre Singapore [NCCS; 114] SYSUCC-B [n 193 (validation cohorts)]) underwent treatment IMRT 2001 2015. Primary secondary clinical end points were overall...
Greater toxicities have been recognized to be a consequence of combined chemotherapy and radiotherapy in the treatment locally advanced non-small-cell lung cancer (NSCLC). This study was designed determine if use amifostine could reduce treatment-related associated with paclitaxel plus carboplatin thoracic radiotherapy.Sixty patients unresectable stage III NSCLC were treated two cycles 175 mg/m2 (area under time-concentration curve = 6), followed by (64 Gy) concurrent weekly 60 mg/m2....
Endemic nasopharyngeal carcinoma (NPC) commonly metastasizes to the lungs, liver, and bones. This study aims assess efficacy of 4 distant metastasis staging modalities, namely (1) conventional work-up comprising chest X-ray, liver ultrasound, skeletal scintigraphy, (2) CT thorax, abdomen, (3) (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET), (4) integrated FDG-PET/CT.Seventy-eight consecutive patients diagnosed with NPC were enrolled followed up for a minimum 6 months confirm...
Objective: Radiomics pipelines have been developed to extract novel information from radiological images, which may help in phenotypic profiling of tumours that would correlate prognosis. Here, we compared two publicly available for radiomics analyses on head and neck CT MRI nasopharynx cancer (NPC). Methods materials: 100 biopsy-proven NPC cases stratified by T- N-categories were enrolled this study. Two pipeline, Moddicom (v. 0.51) Pyradiomics 2.1.2) used features MRI. Segmentation primary...
The recently published ADAURA study has posed a significant dilemma for clinicians in selecting patients adjuvant osimertinib. Risk factors recurrence early-stage epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC) also remain undefined.To determine clinicopathologic characteristics and patterns of resected EGFR-positive NSCLC, using wildtype EGFR as comparator cohort, identify features associated with recurrence.This is cohort including diagnosed AJCC7 Stage...
ABSTRACT Background Local recurrence of nasopharyngeal carcinoma (NPC) occurs in 10%–20% patients, with salvage potential early recurrences. Yet, clear surveillance protocols are lacking. We compare survival outcomes and suitability for symptomatic incidentally detected locally recurrent NPC. Methods Locally NPC initially diagnosed at the National Cancer Center Singapore between October 2003 November 2009, were identified. Demographics, symptoms, detection modalities, analyzed. Results...
Objectives This purpose of this study was to examine clinical-pathologic factors – particularly smoking and brain metastases in EGFR mutation positive (M+) lung adenocarcinoma (ADC) determine their impact on survival patients treated with first line TKI. Methods A retrospective review reflex testing experience for all ADC diagnosed at a tertiary Asian cancer centre from January 2009 April 2013. Amongst cohort, advanced M+ TKI were identified that influence progression free overall survival....
Abstract Background. The aim of this study was to review our experience and demonstrate the safety intracavitary brachytherapy (ICB) in patients with nasopharyngeal carcinoma (NPC). Methods. Hundred seventy‐eight early T1‐2b disease underwent radical external beam radiation therapy (EBRT) followed by ICB boost. primary tumor received 66 Gy EBRT over 33 fractions using 6 or 10 MV photons. insertions were performed 1 week later, delivering 2 8 days. Kaplan‐Meier survival analyses used...
Abstract Objectives. Radiotherapy to head and neck tumors can potentially damage the auditory pathways. This has relevance in cochlear implants there is a need for clinical studies confirm feasibility of implantation these patients. Methods. The records all patients who had received at our institution were reviewed this retrospective study those prior irradiation further studied. Case controls consisted comparable implant recipients did not have radiotherapy. Results. Four 230 met criteria...
To characterize longitudinal changes in Epstein-Barr virus (EBV) DNA post-radiotherapy nasopharyngeal carcinoma (NPC) patients, and investigate whether an early (0-2 weeks) or delayed (8-12 EBV result better predicts for disease-free survival (DFS).Histologically-confirmed NPC patients with ≥1 test quantified using the harmonized BamHI-W polymerase chain reaction-based assay at 0-2 8-12 weeks were included.We identified 302 measured post-radiotherapy; of which, 110 (36.4 %) underwent a...
This is a retrospective study aimed to analyse the outcomes of oral tongue cancer with emphasis on young people.Patients treated radically between 1998 and 2006 were included categorised according treatment modalities (Group A: Surgery, Group B: Surgery adjuvant therapy, C: Definitive radiotherapy) age groups (≤ 40 > years). Overall survival (OS), disease-free (DFS), locoregional relapse-free (LRS) metastasis-free (MFS) estimated using Kaplan-Meier method.There 123 patients 32%, 53% 15% in...