A5014738998- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Oral health in cancer treatment
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Endometrial and Cervical Cancer Treatments
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Management of metastatic bone disease
- Cancer Genomics and Diagnostics
- Salivary Gland Disorders and Functions
- Radiation Dose and Imaging
- Barrier Structure and Function Studies
- Colorectal and Anal Carcinomas
- Polyomavirus and related diseases
National Cancer Centre Singapore
2015-2025
Duke-NUS Medical School
2016-2023
National University of Singapore
2021
SingHealth
2016
La Ligue Contre le Cancer
2016
Centre de recherche en Epidémiologie et Santé des Populations
2016
Université Paris-Saclay
2016
Inserm
2016
Institut Gustave Roussy
2016
Université Paris-Sud
2016
Because of the unprecedented disruption health care services caused by COVID-19 pandemic, American Society Radiation Oncology (ASTRO) and European for Radiotherapy (ESTRO) identified an urgent need to issue practice recommendations radiation oncologists treating head neck cancer (HNC) in a time limited resources heightened risk patients staff.
Purpose: Because of the uneven geographic distribution and small number randomized trials available, value additional induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) remains controversial. This study performed an individual patient data (IPD) pooled analysis better assess precise role IC + CCRT locoregionally advanced NPC.Experimental Design: Four endemic areas were identified, representing 1,193 patients; updated IPD obtained....
Abstract Quantification of Epstein-Barr virus (EBV) cell-free DNA (cfDNA) is commonly used in clinical settings as a circulating biomarker nasopharyngeal carcinoma (NPC), but there has been no comparison with tumour cells (CTCs). Our study aims to compare the performance CTC enumeration against EBV cfDNA quantitation through digital PCR (dPCR) and quantitative PCR. 74 plasma samples from 46 NPC patients at baseline one month after radiotherapy or without concurrent chemotherapy were...
Purpose To investigate for a prognostic index (PI) to personalize recommendations salvage intensity-modulated radiotherapy (IMRT) in patients with locally recurrent nasopharyngeal carcinoma (lrNPC). Methods Patients lrNPC from two academic institutions (Sun Yat-Sen University Cancer Center [SYSUCC-A; n = 251 (training cohort)] and National Centre Singapore [NCCS; 114] SYSUCC-B [n 193 (validation cohorts)]) underwent treatment IMRT 2001 2015. Primary secondary clinical end points were overall...
Objective: Radiomics pipelines have been developed to extract novel information from radiological images, which may help in phenotypic profiling of tumours that would correlate prognosis. Here, we compared two publicly available for radiomics analyses on head and neck CT MRI nasopharynx cancer (NPC). Methods materials: 100 biopsy-proven NPC cases stratified by T- N-categories were enrolled this study. Two pipeline, Moddicom (v. 0.51) Pyradiomics 2.1.2) used features MRI. Segmentation primary...
Chemotherapy, when added to radiotherapy, improves survival in locally advanced nasopharyngeal carcinoma (NPC). This article presents the second update of Meta-Analysis Chemotherapy NPC.Published or unpublished randomized trials assessing radiotherapy (±a chemotherapy timing) with/without non-metastatic NPC patients were identified. Updated data sought for studies included previous rounds meta-analysis. The primary endpoint was overall survival. All analyzed following intent-to-treat...
The COVID-19 pandemic has changed the healthcare landscape drastically. Stricken by sharp surges in morbidity and mortality with resource manpower shortages confounding their efforts, medical community witnessed high rates of burnout post-traumatic stress amongst themselves. Whilst prevailing literature offered glimpses into professional war, no review thus far collated deeply personal reflections physicians ascertained how self-concept, self-esteem perceived self-worth altered during this...
ABSTRACT Background Local recurrence of nasopharyngeal carcinoma (NPC) occurs in 10%–20% patients, with salvage potential early recurrences. Yet, clear surveillance protocols are lacking. We compare survival outcomes and suitability for symptomatic incidentally detected locally recurrent NPC. Methods Locally NPC initially diagnosed at the National Cancer Center Singapore between October 2003 November 2009, were identified. Demographics, symptoms, detection modalities, analyzed. Results...
Abstract Background To evaluate changes in xerostomia status, salivary characteristics and gland volumes 2 years following radiotherapy nasopharyngeal carcinoma patients. Methods Xerostomia scores, flow rates, pH buffering capacity were measured at pre‐radiotherapy, mid‐radiotherapy, weeks, 3 months post‐radiotherapy. Salivary their correlation with radiation dose also assessed. Results Mean to oral cavity, parotid submandibular glands (SMG) was 44.5, 65.0 38.6 Gy respectively. Parotid SMG...
6010 Background: Stage IVA NPC had the worst prognosis despite current standard of neoadjuvant chemotherapy and concurrent chemoradiation (CRT). There is no safety efficacy data combining immune checkpoint inhibitor (ICI) CRT in NPC. Methods: We conducted an open label, single arm, multi-site, phase 2 clinical trial AJCC 8th Edition (T4 and/or N3, M0) WHO type 2/3 Epstein Barr virus (EBV) +ve (Clinical register NCT03734809). The experimental treatment consisted pembrolizumab (200 mg D1),...