A5083245999- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Immune Response and Inflammation
- Advanced X-ray and CT Imaging
- Ferroelectric and Piezoelectric Materials
- Brain Metastases and Treatment
- Oral health in cancer treatment
- Respiratory viral infections research
- Lymphoma Diagnosis and Treatment
- Acoustic Wave Resonator Technologies
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Medical Imaging Techniques and Applications
- NF-κB Signaling Pathways
- Global Cancer Incidence and Screening
National Cancer Centre Singapore
2016-2024
Duke-NUS Medical School
2016-2023
Singapore General Hospital
2015
Chemotherapy, when added to radiotherapy, improves survival in locally advanced nasopharyngeal carcinoma (NPC). This article presents the second update of Meta-Analysis Chemotherapy NPC.Published or unpublished randomized trials assessing radiotherapy (±a chemotherapy timing) with/without non-metastatic NPC patients were identified. Updated data sought for studies included previous rounds meta-analysis. The primary endpoint was overall survival. All analyzed following intent-to-treat...
Current proposed mechanisms implicate both early and latent Epstein–Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with childhood EBV chronic ear, nose, sinus conditions. Moreover, most patients NPC present IgA antibody titers to capsid antigen (VCA-IgA), which can precede actual tumor presentation by several years. If indeed constitutes a key event carcinogenesis, one would explain inability...
Abstract A feasibility study was performed to determine if CT-based radiomics could play an augmentative role in predicting neoadjuvant rectal score (NAR), locoregional failure free survival (LRFFS), distant metastasis (DMFS), disease (DFS) and overall (OS) locally advanced cancer (LARC). The NAR score, which takes into account the pathological tumour nodal stage as well clinical stage, is a validated surrogate endpoint used for early determination of treatment response whereby low (< 8)...
6523 Background: Based on an individual patient data (IPD) network meta-analysis (NMA) of 20 randomized trials and 5,144 patients (pts), the MAC-NPC collaborative group has shown that addition adjuvant chemotherapy (AC) to chemo-radiotherapy (CRT) achieved highest survival benefit in nasopharyngeal carcinoma (NPC; Ribassin-Majed JCO 2017). Here, we updated with 8 trials. Methods: Trials Radiotherapy (RT) or without (CT) non-metastatic NPC were identified IPD obtained. Both Western Chinese...
Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)—(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining evidence for vertical transmission HPV infection. (c) relationship between Epstein–Barr (EBV) nasopharyngeal cancer (NPC) in West European, East Asian countries. (d) association HPV-positive OPC...
Abstract: GRID or spatially fractionated radiation therapy was historically used in the orthovoltage era to deliver large single 15–20 Gy doses of radiotherapy tumours greater than 6 cm by creating a dosimetric distribution that is comprised intervening "hot" and "cold" spots within tumour. However, despite impressive response rates 70% with at such non-tumoricidal doses, technique quickly fell out favour advent megavoltage linear accelerators. With introduction modern techniques like...
Objectives and importanceCochlear implantation is an established, reliable, safe procedure with a low complication rate. Electrode array extrusion through the posterior aspect of external ear canal potential major cochlear implant surgery that may result in revision or explantation. Although there have been previous case reports such extrusions tympanic membrane, this first well-documented report wall which was previously intact.Clinical presentationIn report, we present electrode extruding...
Neoadjuvant Rectal Score (NAR score) is a short-term endpoint developed for clinical trials involving rectal cancer. It can be used as an early evaluation of neoadjuvant treatment response. In this study, we aim to develop machine learning model based on radiomics features extracted from T2w magnetic resonance images (MRI) obtained pre-operatively predict two different binary outcomes, NAR>16 and NAR<8. 112 unique patients who had undergone chemoradiation (NAC) followed by total mesorectal...
Background and purposeHigh-density dental fillings pose a non-negligible impact on head neck cancer treatment. For proton therapy, stopping power ratio (SPR) prediction will be significantly impaired by the associated image artifacts. Dose perturbation is also inevitable, compromising treatment plan quality. While plenty of work has been done metal or amalgam fillings, none touched composite resin (CR) glass ionomer cement (GIC) which have seen an increasing usage. Hence, this aims to...
Abstract A feasibility study was performed to determine if CT-based radiomics could play an augmentative role in predicting neoadjuvant rectal score (NAR), locoregional failure free survival (LRFFS), distant metastasis (DMFS), disease (DFS) and overall (OS) locally advanced cancer (LARC). CT images of 191 patients with LARC were used this study. Primary tumour (GTV) mesorectum (CTV) contoured separately features extracted from both segments. Two NAR models (NAR>16 NAR<8) constructed...
The COVID-19 pandemic has resulted in significant healthcare implications, with care for cancer patients compromised due to resource diversion towards battling the pandemic. We aim investigate impact of peak wave 2020 on delivery Singapore, specifically via our nasopharyngeal carcinoma (NPC) treatment data. This study applies real world numbers Singapore. choice allows a good direct estimate common measures such as time biopsy, staging scans, commencement, its clear protocol and algorithms...
Background and purposeHigh-density dental fillings pose a non-negligible impact on head neck cancer treatment. For proton therapy, stopping power ratio (SPR) prediction will be significantly impaired by the associated metal artifacts. Dose perturbation is also inevitable, thus compromising treatment plan quality. While plenty of work has been done or amalgam fillings, none touched composite resin (CR) glass ionomer cement (GIC) which have seen an increasing usage. Hence, this aims to provide...