A5016090230- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Immune Cell Function and Interaction
- Radiation Therapy and Dosimetry
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
University of Hong Kong
2016-2025
University of Hong Kong - Shenzhen Hospital
2016-2025
Chinese University of Hong Kong
2015-2025
Union for International Cancer Control
2024
Pamela Youde Nethersole Eastern Hospital
2010-2022
Queen Mary Hospital
2005-2022
Ji Hua Laboratory
2022
University Grants Committee
2018-2021
Roche (Switzerland)
2018
Pfizer (Spain)
2018
This randomized study compared the results achieved by concurrent chemoradiotherapy (CRT) versus radiotherapy (RT) alone for nasopharyngeal carcinoma (NPC) with advanced nodal disease.Patients nonkeratinizing/undifferentiated NPC staged T1-4N2-3M0 were to CRT or RT. Both arms treated same RT technique and dose fractionation. The patients given cisplatin 100 mg/m2 on days 1, 22, 43, followed 80 fluorouracil 1,000 mg/m2/d 96 hours starting 71, 99, 127.From 1999 January 2004, 348 eligible...
Purpose The role of adjuvant chemotherapy (AC) or induction (IC) in the treatment locally advanced nasopharyngeal carcinoma is controversial. individual patient data from Meta-Analysis Chemotherapy Nasopharynx Carcinoma database were used to compare all available treatments. Methods All randomized trials radiotherapy (RT) with without nonmetastatic considered. Overall, 20 and 5,144 patients included. Treatments grouped into seven categories: RT alone (RT), IC followed by (IC-RT), AC (RT-AC),...
An accurate staging system is crucial for cancer management. Evaluations continual suitability and improvement are needed as treatment methods evolve.This was a retrospective study of 1609 patients with nasopharyngeal carcinoma investigated by magnetic resonance imaging, staged the 7th edition American Joint Committee on Cancer (AJCC)/International Union Against (UICC) system, irradiated intensity-modulated radiotherapy at 2 centers in Hong Kong mainland China.Among without other T3/T4...
The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that spread human-to-human respiratory secretions. It was declared the WHO as public health emergency. most susceptible populations, needing mechanical ventilation, are elderly and people with associated comorbidities. There an important risk of contagion for anesthetists, dentists, head neck surgeons, maxillofacial ophthalmologists, otolaryngologists. Health workers represent between 3.8%...
Abstract The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, prognosis. However, recent advances based on bulk RNA sequencing remain insufficient construct an in-depth landscape infiltrating cells in NPC. Here we apply single-cell 66,627 from 14 patients, integrated with clonotype identification T B cells....
Abstract Despite the intense CD8+ T-cell infiltration in tumor microenvironment of nasopharyngeal carcinoma, anti-PD-1 immunotherapy shows an unsatisfactory response rate clinical trials, hindered by immunosuppressive signals. To understand how microenvironmental characteristics alter immune homeostasis and limit efficacy here we establish a multi-center single-cell cohort based on public data, containing 357,206 cells from 50 patient samples. We reveal that carcinoma enhance development...
A retrospective analysis was undertaken of the late complications observed in 4527 patients with nasopharyngeal carcinoma treated by megavoltage radiotherapy during years 1976-1985. Unconventional fractionation schedules were used because serious resource limitations. The median equivalent doses 65 Gy to region and 53 cervical region. 707 had reirradiation for local recurrences 250 regional relapses. 10-year actuarial cancer-specific survival 47%, corresponding all-complication-free...
This is a preliminary report of 102 patients with clinical diagnosis late temporal lobe necrosis after radical radiation therapy for nasopharyngeal carcinoma during 1964 to 1983. Histologic verification was available in 12 cases. All but three had been treated our institute using schedules doses larger than the conventional 200 cGy per fraction. The incidence rate 1.03%. In 80 only one course external irradiation, lobes ranged from 1665 2127 ret, or 1286 1778 brain tolerance unit (btu)....
Abstract Background. The purpose of this article is to report the overall survival (OS) outcome patients with nasopharyngeal carcinoma (NPC) local failure who received salvage treatment and identify prognostic factors for OS. Methods. Between January 1996 December 2000, 2915 primary radiotherapy (RT) or without chemotherapy nonmetastatic NPC. At a median follow‐up 3.1 years, 319 had developed as first failure, synchronous regional/distant failure. OS was calculated from start RT. Univariate...