A5059394561- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Genomics and Rare Diseases
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Vitamin D Research Studies
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
Roswell Park Comprehensive Cancer Center
2015-2024
Institute of Bioinformatics
2022
Cancer Genetics (United States)
2003-2021
IQE (United Kingdom)
2018-2019
Thermo Fisher Scientific (United States)
2019
James Graham Brown Foundation
2018
University of Louisville
2018
Kent State University
2018
National Institutes of Health
2015
NorthShore University HealthSystem
2014
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles miRNAs in carcinogenesis. We and others have shown profiles different lung cancer vs. normal lung, although the significance this aberrant is poorly understood. Among reported down-regulated cancer, miRNA (miR)-29 family (29a, 29b, 29c) has intriguing complementarities to 3'-UTRs DNA methyltransferase (DNMT)3A -3B (de novo methyltransferases), two key enzymes involved...
Abstract Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence progression by modulating expression of matrix metalloproteinases (MMP) vascular endothelial growth factor (VEGF). The purpose this study is to determine if stress hormone norepi can MMP-2, MMP-9, VEGF in nasopharyngeal carcinoma (NPC) tumors three NPC tumor cell lines. lines HONE-1, HNE-1, CNE-1 were treated with norepi. effects on...
Cells with sphere forming capacity, spheroid cells, are present in the malignant ascites of patients epithelial ovarian cancer (EOC) and represent a significant impediment to efficacious treatment due their putative role progression, metastasis chemotherapy resistance. The exact mechanisms that underlie EOC drug resistance not clear. Understanding biology cells may contribute identification novel therapeutic opportunities for metastatic EOC. Here we generated from human cell lines primary...
Abstract Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers; however, durable response is limited to only a subset of patients. Discovery blood-based biomarkers that reflect dynamic change the tumor microenvironment, and predict ICI, will markedly improve current regimens. Here, we investigate CX3C chemokine receptor 1 (CX3CR1), marker T-cell differentiation, as predictive correlate ICI therapy. Successful tumor-bearing mice with increases frequency...
To evaluate HER-2 expression and amplification in a large cohort of endometrial cancer with complete surgical staging outcome data.A tissue microarray was constructed 483 patients diverse histologic type stage tested for using current standards practice. There data 83% all 81% staging.Both associated high-grade (P = .0001) high cancer. The highest rate seen serous carcinoma (43% 29%), while grade 1 endometrioid adenocarcinoma showed the lowest levels (3% 1%). For types, remarkably different...
Abstract Purpose: A reliable method for diagnosing parathyroid carcinoma has remained elusive over the years, resulting in its under-recognition and suboptimal therapy. Obtaining an accurate diagnosis become even more pressing matter with recent evidence that germline HRPT2 gene mutations are found patients apparently sporadic carcinoma. There is a high prevalence of biallelic inactivation We hypothesize loss parafibromin, protein product gene, would distinguish from benign tissue....
Lung cancer is the leading cause of cancer-related death, with non-small cell lung (NSCLC) being predominant form disease. Most caused by accumulation genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCLCs and their matched normal tissue samples. We identified both common unique mutation spectra pathway activation adenocarcinomas squamous carcinomas, two major histologies NSCLC. In addition identifying previously...
Increased expression of eicosanoids in cancer has been associated with adverse prognosis. We performed a randomized phase II trial to test the hypothesis that inhibitors two eicosanoid pathways (cyclooxygenase-2 [COX-2], celecoxib and 5-lipoxygenase [5-LOX], zileuton) added chemotherapy would improve outcome advanced non-small-cell lung (NSCLC).Patients NSCLC, performance status 0 2, no prior therapy were eligible. All patients received carboplatin area under curve (AUC) 5.5 mg/mL x min day...
Metastatic tumors presenting as soft tissue masses are relatively rare and can be the source of diagnostic confusion both clinically pathologically. The authors' experience was reviewed at a large academic medical center over 30-year period (1971-2000) with metastases to tissue.The in study included mainly lesions involving skeletal muscle or subcutaneous upper lower limbs, trunk, shoulders, buttocks. Direct extension from originating bone adjacent organs, skin areas known contain abundant...
The facilitates chromatin transcription (FACT) complex is involved in remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed not associated with any disease. However, we discovered that the target of a class anticancer compounds normal cells adult mammalian tissues, except for undifferentiated stem-like cells. Here, show expression strongly poorly differentiated aggressive cancers low overall survival. In addition, found...
<h3>Background</h3> Immune checkpoint inhibitors (ICIs) have changed the clinical management of melanoma. However, not all patients respond, and current biomarkers including PD-L1 mutational burden show incomplete predictive performance. The validity utility complex been studied in <h3>Methods</h3> Cutaneous metastatic melanoma at eight institutions were evaluated for expression, CD8<sup>+</sup> T-cell infiltration pattern, burden, 394 immune transcript expression. IHC assessed association...
Our previous work has shown low serum 25-hydroxyvitamin D concentrations in association with aggressive breast cancer subtypes. Vitamin receptor (VDR) is central for vitamin D-mediated transcription regulation. Few studies have examined VDR expression tumor characteristics or patient survival.VDR tissue microarrays was determined by immunohistochemistry 1,114 female patients as low, moderate, and strong based on an immunoreactive score, histopathologic survival outcomes including...
<h3>Background</h3> Resistance to immune checkpoint inhibitors (ICIs) has been linked local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors influence sensitivity ICIs in non-small cell lung cancer (NSCLC) patients. <h3>Methods</h3> Tumor specimens from 120 NSCLC patients 10 institutions were evaluated for by immunohistochemistry, and global proliferative profile targeted...
PD-L1 immunohistochemistry (IHC) has been traditionally used for predicting clinical responses to immune checkpoint inhibitors (ICIs). However, there are at least 4 different assays and antibodies IHC, each developed with a ICI. We set test if next generation RNA sequencing (RNA-seq) is robust method determine mRNA expression levels furthermore, efficacy of response ICIs as compared routinely used, standardized IHC procedures.A total 209 cancer patients treated on-label by FDA-approved ICIs,...
Thyroid carcinoma is a common endocrine cancer with favorable prognosis if subjected to timely treatment. However, the clinical identification of follicular thyroid (FTC) among patients benign nodules still challenge. Preoperative fine needle aspiration-based cytology cannot always differentiate carcinomas from neoplasias. Because current methods fail improve preoperative diagnosis nodules, new molecular-based diagnoses should be explored. We conducted microarray-based study reveal genetic...
Amongst hyperparathyroidism-related syndromes, hyperparathyroidism-jaw tumour syndrome is one of the least common and relatively unknown but its clinical genetic aspects are not less interesting or important. With recent identification genes, we can now better characterize disease, both clinically genetically, which will certainly impact field endocrinology oncology. In this article, review clinico-pathological features basis with hope that it create awareness interest in disease amongst...
The identification of tumor suppressor genes has classically depended on their localization within recurrent regions loss heterozygosity. According to Knudson's two-hit hypothesis, the remaining allele is lost, either genetically or, more recently identified, through epigenetic events. To date, retrospective analyses have determined promoter methylation as a common alternative alteration in cancer cells silence cancer-related genes. Here we report an application restriction landmark genomic...