A5024815774- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Anorectal Disease Treatments and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Metastasis and carcinoma case studies
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Cutaneous Melanoma Detection and Management
Christiana Care Health System
2015-2024
The Wistar Institute
2024
NSABP Foundation
1993-2023
Bank of America
2015-2023
Temple University Hospital
2020
Arete (United Kingdom)
2020
Thomas Jefferson University
2003-2019
NRG Oncology
2016-2018
California Northstate University
2018
University of Toronto
2018
Background: Oncologic resection techniques affect outcome for colon cancer and rectal cancer, but standardized guidelines have not been adopted. The National Cancer Institute sponsored a panel of experts to systematically review current literature draft that provide uniform definitions, principles, practices. Methods: Methods were similar those described by the American Society Clinical Oncology in developing practice guidelines. Experts representing oncology surgery met on oncologic level...
Experimental studies in animals and observational humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, precursors to most cancers.
PURPOSE Definitive chemoradiation (CR) has replaced radical surgery as the preferred treatment of epidermoid carcinoma anal canal. To determine importance mitomycin (MMC) in standard CR regimen and to assess role salvage patients who have residual tumor following CR, a phase III randomized trial was undertaken by Radiation Therapy Oncology Group (RTOG)/Eastern Cooperative (ECOG). PATIENTS AND METHODS Between August 1988 December 1991, 310 were receive either radiotherapy (RT) fluorouracil...
This phase III clinical trial evaluated the impact on disease-free survival (DFS) of adding oxaliplatin to bolus weekly fluorouracil (FU) combined with leucovorin as surgical adjuvant therapy for stage II and colon cancer.Patients who had undergone a potentially curative resection were randomly assigned either FU 500 mg/m2 intravenous (IV) 6 weeks plus IV during each 8-week cycle three cycles (FULV), or same FULV regimen 85 administered 1, 3, 5 (FLOX).A total 2,407 patients (96.6%) 2,492...
Purpose Although chemoradiotherapy plus resection is considered standard treatment for operable rectal carcinoma, the optimal time to administer this therapy not clear. The NSABP R-03 (National Surgical Adjuvant Breast and Bowel Project R-03) trial compared neoadjuvant versus adjuvant in of locally advanced carcinoma. Patients Methods with clinical T3 or T4 node-positive cancer were randomly assigned preoperative postoperative chemoradiotherapy. Chemotherapy consisted fluorouracil leucovorin...
Abstract Regulation of the MYC oncogene remains unclear. Using 10058-F4, a compound that inhibits MYC-MAX transcription factor, protein and gene expression were down-regulated in Namalwa cells, Burkitt lymphoma. Compound 10058-F4 decreased mRNA (45%), (50%), cell growth (32%). factor was disrupted 24 h after treatment, resulting transcriptional inhibition target genes. Because microRNAs (miRNA) disrupt translation, let-7a, let-7b, mir-98 selected using bioinformatics for targeting MYC....
PURPOSE This study was designed to evaluate the efficacy of leucovorin-modulated fluorouracil (5-FU) as adjuvant therapy for patients with Dukes' stage B and C colon cancer. PATIENTS AND METHODS Data are presented from 1,081 carcinoma entered into National Surgical Adjuvant Breast Bowel Project (NSABP) protocol C-03 between August 1987 April 1989. Patients were randomly assigned receive either lomustine (MeCCNU), vincristine, 5-FU (MOF), or (LV + 5-FU). The mean time on 47.6 months. RESULTS...
The National Surgical Adjuvant Breast and Bowel Project (NSABP) C-07 trial demonstrated that the addition of oxaliplatin to fluorouracil plus leucovorin (FULV) improved disease-free survival (DFS) in patients with stage II or III colon cancer. This analysis is first publication overall (OS) for NSABP study. We updated DFS examined both end points clinically relevant patient subsets.
The National Surgical Adjuvant Breast and Bowel Project C-08 trial was designed to investigate the safety efficacy of adding bevacizumab modified FOLFOX6 (mFOLFOX6; ie, infusional/bolus fluorouracil, leucovorin, oxaliplatin) for adjuvant treatment patients with stages II III colon cancer.Patients received mFOLFOX6 every 2 weeks 26 alone or as + (5 mg/kg 52 [ie, experimental group]). primary end point disease-free survival (DFS).Among 2,672 analyzed patients, demographic factors were well...
To update the 2000 American Society of Clinical Oncology guideline on colorectal cancer surveillance.Based results from three independently reported meta-analyses randomized controlled trials that compared low-intensity and high-intensity programs surveillance, recent analyses data major clinical in colon rectal cancer, Panel recommends annual computed tomography (CT) chest abdomen for 3 years after primary therapy patients who are at higher risk recurrence could be candidates...
A total of 343 patients with previously untreated metastatic measurable colorectal carcinoma were studied to evaluate the impact on toxicity, response, and survival leucovorin-modulated fluorouracil (5-FU). maximally tolerated intravenous bolus loading course regimen 5-FU alone (500 mg/m2 x 5 days every 4 weeks 25 escalation) was compared a high-dose leucovorin (600 500 weekly for 6 2-week rest) similar low-dose rest). The dose-limiting toxicity two regimens gastrointestinal, specifically...
Seventy-four previously untreated patients with metastatic colorectal adenocarcinoma were prospectively randomized into one of three treatment regimens: (1) 5-fluorouracil (5-FU) 450 mg/m2 as an intravenous (IV) bolus daily for five days or toxicity, then 200 IV every other day six doses; (2) methotrexate (MTX) 50 in normal saline by infusion over four hours followed 5-FU 600 mg/m2. This was administered weekly 4 weeks and 2 weeks. (3) Leucovorin 500 a two-hour hour after the began week 6...
The optimal chemotherapy regimen administered concurrently with preoperative radiation therapy (RT) for patients rectal cancer is unknown. National Surgical Adjuvant Breast and Bowel Project trial R-04 compared four regimens concomitantly RT.Patients clinical stage II or III who were undergoing RT (45 Gy in 25 fractions over 5 weeks plus a boost of 5.4 to 10.8 three six daily fractions) randomly assigned one the following regimens: continuous intravenous infusional fluorouracil (CVI FU; 225...
Cancer cell genomes contain alterations beyond known etiologic events, but their total number has been unknown at even the order of magnitude level. By sampling colorectal premalignant polyp and carcinoma through use technique inter-(simple sequence repeat) PCR, we have found genomic to be considerably more abundant than expected, with mean events per totaling approximately 11,000. Colonic polyps early in tumor progression pathway showed similar numbers events. These results indicate that,...
We report here the results of first multiinstitutional prospective evaluation patients considered to have potentially resectable hepatic metastases from colorectal carcinoma. One hundred fifty-six were enrolled 15 institutions. Six subsequently excluded. fifty underwent surgery and are evaluable for analysis (median follow-up time, 3.1 years; range, 4 months 5.1 years). Curative resection could be performed on 46% (69 150), noncurative 12% (18 while 42% found unresectable (63 150)....
In this review of a collected series patients undergoing hepatic resection for colorectal metastases, 100 were found to have survived greater than five years from the time resection. Of these long-term survivors, 71 remain disease-free through last follow-up, 19 recurred prior years, and ten after years. Patient characteristics that may contributed survival examined. Procedures performed included trisegmentectomies, 32 lobectomies, 16 left lateral segmentectomies, 45 wedge resections. The...
Purpose The American Society of Clinical Oncology (ASCO) has a policy and set procedures for endorsing recent clinical practice guidelines that have been developed by other professional organizations. Methods Cancer Care Ontario (CCO) Guideline on Follow-up Care, Surveillance Protocol, Secondary Prevention Measures Survivors Colorectal was reviewed ASCO methodologic rigor considered endorsement. Results Panel concurred with the CCO recommendations recommended endorsement, addition several...
The primary aim of this study was to compare the relative efficacy oral uracil and tegafur (UFT) plus leucovorin (LV) with weekly intravenous fluorouracil (FU) LV in prolonging disease-free survival (DFS) overall (OS) after surgery for colon carcinoma.Between February 1997 March 1999, 1,608 patients stage II III carcinoma were randomly assigned receive either UFT+LV or FU+LV.Of total patients, 47% had cancer, 53% cancer. Median follow-up time 62.3 months. estimated hazard ratio (HR) OS who...
The purpose of this study was to examine the prognostic and oxaliplatin predictive value mismatch repair (MMR) status common hot spot mutations, which we previously identified in stage II III colon cancer.Mutations BRAF, KRAS, NRAS, MET, PIK3CA were profiled 2,299 tumors from National Surgical Adjuvant Breast Bowel Project (NSABP) clinical trials C-07 (n = 1,836) C-08 463) with Type Plex chemistry mass spectrometry. tested worth adding 5-fluorouracil plus leucovorin, bevacizumab FOLFOX. Cox...
PURPOSE: National Surgical Adjuvant Breast and Bowel Project Protocol R-03 was designed to determine the worth of preoperative chemotherapy radiation therapy in management operable rectal cancer. METHODS: Thus far, 116 patients an eventual 900 with primary cancer have been randomized receive multimodality begin preoperatively (59 patients) or identical beginning after curative surgery (57). All received seven cycles 5-fluorouracil (FU)/leucovorin (LV) chemotherapy. Cycles 1 4 through 7 used...