A5040292764- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Occupational and environmental lung diseases
- Hernia repair and management
- Hepatocellular Carcinoma Treatment and Prognosis
- Adrenal and Paraganglionic Tumors
- Sarcoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Pituitary Gland Disorders and Treatments
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Cancer and Skin Lesions
- Colorectal Cancer Treatments and Studies
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Breast Implant and Reconstruction
Atrium Health Wake Forest Baptist
2016-2025
Wake Forest University
2015-2024
Hospices Civils de Lyon
2009-2024
University of Messina
2024
Institut National d'Oncologie
2024
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Policlinico Abano Terme
2024
Ospedale Policlinico San Martino
2024
Wake Forest Baptist Comprehensive Cancer Center
2015-2023
Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., until death from melanoma) among patients node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for sentinel-node metastases not clear.
The three principal studies dedicated to the natural history of peritoneal carcinomatosis (PC) from colorectal cancer consistently showed median survival ranging between 6 and 8 months. New approaches combining cytoreductive surgery perioperative intraperitoneal chemotherapy suggest improved survival.A retrospective multicenter study was performed evaluate international experience with this combined treatment identify prognostic indicators. All patients had (intraperitoneal chemohyperthermia...
This phase III clinical trial evaluated the impact on disease-free survival (DFS) of adding oxaliplatin to bolus weekly fluorouracil (FU) combined with leucovorin as surgical adjuvant therapy for stage II and colon cancer.Patients who had undergone a potentially curative resection were randomly assigned either FU 500 mg/m2 intravenous (IV) 6 weeks plus IV during each 8-week cycle three cycles (FULV), or same FULV regimen 85 administered 1, 3, 5 (FLOX).A total 2,407 patients (96.6%) 2,492...
Pseudomyxoma peritonei (PMP) originating from an appendiceal mucinous neoplasm remains a biologically heterogeneous disease. The purpose of our study was to evaluate outcome and long-term survival after cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) consolidated through international registry study.A retrospective multi-institutional established collaborative efforts participating units affiliated with the Peritoneal Surface Oncology Group International.Two...
Purpose This multi-institutional registry study evaluated cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for diffuse malignant peritoneal mesothelioma (DMPM). Patients and Methods A data that included 405 patients DMPM treated by a uniform approach used CRS HIPEC was established. The primary end point overall survival. secondary evaluation of prognostic variables Results Follow-up complete in 401 (99%). median follow-up period the who were alive...
Pseudomyxoma peritonei is a clinical term for gelatinous ascites, usually secondary to an appendiceal tumor. The pathologic classification of pseudomyxoma and its associated tumors has been plagued with controversy confusing terminology. In effort clarify this, we reviewed the pathology 101 patients, all treated at our institution from 1993 2005, origin. All patients were uniformly standardized protocol. This largest series solely devoted neoplasia ascites. cases assigned, according...
Restorative yoga (RY) is a gentle type of that may be beneficial for cancer patients and post-treatment survivors. Study goals were: to determine the feasibility implementing RY intervention women with breast cancer; examine group differences in self-reported emotional, health-related quality life, symptom outcomes.
<h3>Importance</h3> Studies on the prognostic role of hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei (PMP) are currently not available. <h3>Objectives</h3> To evaluate outcomes after cytoreductive surgery (CRS) and HIPEC compared with CRS alone patients PMP. <h3>Design, Setting, Participants</h3> This cohort study analyzed data from Peritoneal Surface Oncology Group International (PSOGI) registry, including 1924 histologically confirmed PMP due to an appendiceal...
Abstract: We sought to prospectively assess the diagnostic performance of a high-resolution positron emission tomography (PET) scanner using mild breast compression (positron mammography [PEM]). Data were collected on concomitant medical conditions potential confounding factors. At four centers, 94 consecutive women with known cancer or suspicious lesions received 18F-fluorodeoxyglucose (FDG) intravenously, followed by PEM scans. Readers provided clinical histories and x-ray mammograms (when...
Abstract Background Evaluation of peritoneal metastases by computed tomography (CT) scans is challenging and has been reported to be inaccurate. Methods A multi‐institutional prospective observational registry study patients with carcinomatosis from colorectal cancer was conducted a subset analysis performed examine index (PCI) based on CT intraoperative exploration. Results Fifty‐two (mean age 52.6 ± 12.4 years) 16 institutions were included in this study. Inaccuracies CT‐based assessment...
In Brief Objective: To evaluate the utility of 18F-FDG-PET in predicting response to concomitant chemoradiation locally-advanced esophageal cancer. Summary Background Data: Approximately 25% cancer patients experience a pathologic complete (pCR) preoperative therapy. Computed tomography, endoscopy, and endoscopic ultrasound are unable identify experiencing pCR. Growing evidence supports use staging its ability detect occult metastatic lymph nodal disease. The identification with pCR could...
Genetic variations in DNA repair may impact functions, damage and breast cancer risk. Using data/samples collected from the first 752 Caucasians 141 African-Americans an ongoing case-control study, we examined association between risk 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) four pathways-(i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q POLD1 R119H; (ii) nucleotide ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H XPC A499V/K939Q; (iii) mismatch MLH1...
Abstract BACKGROUND: Currently, no tumor‐node‐metastasis (TNM) staging system exists for patients with diffuse malignant peritoneal mesothelioma (DMPM). The primary objective was to formulate a clinicopathological through the identification of significant prognostic parameters. METHODS: Eight international institutions prospectively collected data on who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy contributed registry. Two hundred ninety‐four had complete...
Anthracycline- and taxane-based three-drug chemotherapy regimens have proven benefit as adjuvant therapy for early-stage breast cancer. This trial (NSABP B-38; Combination Chemotherapy in Treating Women Who Have Undergone Surgery Node-Positive Breast Cancer) asked whether the incorporation of a fourth drug could improve outcomes relative to two standard provided direct comparison those regimens.We randomly assigned 4,894 women with node-positive cancer six cycles docetaxel, doxorubicin,...
To determine whether [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) can delineate patients with esophageal cancer who may not benefit from esophagectomy after chemoradiotherapy.We reviewed records of 163 histologically confirmed stage I to IVA receiving chemoradiotherapy or without resection curative intent. All received surgical evaluation. Initial and postchemoradiotherapy FDG-PET scans prognostic/treatment variables were analyzed. complete response (PET-CR) was defined...
Tumor-infiltrating myeloid cells are the most abundant leukocyte population within tumors. Molecular cues from tumor microenvironment promote differentiation of immature toward an immunosuppressive phenotype. However, in situ dynamics transcriptional reprogramming underlying this process poorly understood. Therefore, we applied single cell RNA-seq (scRNA-seq) to computationally investigate cellular composition and adjacent normal tissues 4 early-stage non-small lung cancer (NSCLC) patients....