A5028648915- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Occupational and environmental lung diseases
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Hernia repair and management
- Cancer therapeutics and mechanisms
- Pharmacogenetics and Drug Metabolism
- Neonatal Health and Biochemistry
- Pancreatic and Hepatic Oncology Research
- Pleural and Pulmonary Diseases
- Drug Transport and Resistance Mechanisms
- Estrogen and related hormone effects
- Gestational Trophoblastic Disease Studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Lymphocytic Leukemia Research
- BIM and Construction Integration
- Endometrial and Cervical Cancer Treatments
- Intestinal and Peritoneal Adhesions
- Biochemical and Molecular Research
- Cancer, Lipids, and Metabolism
Hospices Civils de Lyon
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Hôpital Lyon Sud
2016-2024
Université de Lyon
2019-2024
Centre hospitalier universitaire de Québec
2013-2024
Centre hospitalier de l'Université Laval
2023-2024
Centre de Recherche en Cancérologie de Lyon
2021-2024
Centre Hospitalier De Pau
2020-2024
Centre Hospitalier Universitaire de Saint-Étienne
2024
Université Laval
2010-2023
In Europe, gastric cancer remains diagnosed at advanced stage (serosal and/or lymph node involvement). Despite curative management combining perioperative systemic chemotherapy and gastrectomy with D1-D2 dissection, 5-year survival rates of T3 N + patients remain under 30%. More than 50% recurrences are peritoneal locoregional. The use adjuvant hyperthermic intraperitoneal that eliminates free cells can be released into cavity during the prevents carcinomatosis recurrences, was extensively...
<h3>Importance</h3> Studies on the prognostic role of hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei (PMP) are currently not available. <h3>Objectives</h3> To evaluate outcomes after cytoreductive surgery (CRS) and HIPEC compared with CRS alone patients PMP. <h3>Design, Setting, Participants</h3> This cohort study analyzed data from Peritoneal Surface Oncology Group International (PSOGI) registry, including 1924 histologically confirmed PMP due to an appendiceal...
Objectives Polymorphisms in UDP-glucuronosyltransferases (UGTs) can influence detoxifying capacities and have considerable therapeutic implications addition to various (patho)physiological processes. UGT1A9 plays a central role the metabolism of classes drugs carcinogens steroids. The great interindividual variability UGT1A9-mediated glucuronidation remains poorly explained, while evidence for its genetic origin exists. Methods proximal promoter was screened polymorphisms by sequencing and,...
In vitro metabolic studies revealed that along with UDP-glucuronosyltransferase (UGT) 1A1, the hepatic UGT1A9 and extrahepatic UGT1A7 are involved in biotransformation of active toxic metabolite irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38). Variant UGT1A1 alleles have been reported but polymorphic nature <i>UGT1A9</i> gene has not yet. To further clarify molecular determinants irinotecan-induced toxicity, we identified characterized functionality novel polymorphisms determined whether...
Predicting pituitary tumor behavior remains a challenge. This multiparameter investigation aimed to identify markers for recurrence and progression in prolactin tumors.From cohort of patients treated tumors by surgery, we retrospectively studied clinical data, characteristics, outcome, the expression nine genes quantitative RT-PCR.This study included 94 (62 females 32 men), with long postoperative follow-up periods (mean, 138 +/- 46 months); 54.3% had macro or giant adenoma. Tumors were...
Objective To review our 25‐year experience with hyperthermic intra‐peritoneal chemotherapy (HIPEC). Background Combining cytoreductive surgery (CRS) and HIPEC as local treatments for peritoneal carcinomatosis (PC) was proposed 25 years ago. Methods A prospective database of all patients undergoing PC since 1989 searched clinicopathological data, 90‐day morbidity mortality, survival. Results Among 1,125 procedures, origin colorectal (342; 30%), ovarian (271; 24%), pseudomyxoma peritonei (189;...
Enhanced recovery after surgery (ERAS) pathways have been shown to considerably reduce complications, length of stay and costs most surgical procedures by standardised application best evidence-based perioperative care. The aim was elaborate dedicated recommendations for cytoreductive (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC) in a two-part series guidelines based on expert consensus. present part II the highlights postoperative management special considerations.The core group...
Women with gestational trophoblastic tumors (GTT) resistant to single-agent chemotherapy receive alternative regimens, which, although effective, cause considerable toxicity. All GTT subtypes express programmed death-ligand 1 (PD-L1), and natural killer (NK) cells are involved in trophoblast immunosurveillance. Avelumab (anti-PD-L1) induces NK cell-mediated cytotoxicity. The TROPHIMMUN trial assessed avelumab women chemotherapy-resistant GTT.In this phase II multicenter (ClinicalTrials.gov...
In Brief Objectives: To assess the impact of neoadjuvant chemoradiotherapy (NCRT) on anastomotic leakage (AL) and other postoperative outcomes after esophageal cancer (EC) resection. Background: Conflicting data have emerged from randomized studies regarding NCRT AL. Methods: Among 2944 consecutive patients operated for EC between 2000 2010 in 30 European centers, treated by surgery (n = 593) were compared with those primary 1487). Multivariable analyses propensity score matching used to...
Renal metabolism by UDP-glucuronosyltransferase (UGT) enzymes is central to the clearance of many drugs. However, significant discrepancies about relative abundance and activity individual UGT in normal kidney prevail among reports, whereas glucuronidation tumoral has not been examined. In this study, we performed an extensive profiling (<i>n</i> = 12) tumor 14) kidneys using targeted mass spectrometry quantification human UGTs. We then correlated protein concentrations with mRNA levels...
Abstract Background The peritoneal cancer index (PCI) is a comparative prognostic factor for colorectal metastasis (CRPM). ability of laparoscopy to determine the PCI in consideration cytoreductive surgery remains undetermined, and this study was designed compare it with laparotomy. Methods A prospective multicentre conducted patients no known CRPM, but at risk disease. Surgery began laparoscopic exploration followed by open PCI. Concordance between assessment evaluated diagnosis CRPM...
Abstract Background Multimodal treatment, including systemic treatment and surgery, improved the prognosis of peritoneal metastasis (PM). Despite all efforts, recurrence rates remain high, little data are available about clinical behavior or molecular patterns PM in comparison to hematogenous metastasis. Here, we aimed analyze after multimodal for from colorectal cancer. Methods Patients with undergoing chemotherapy cytoreductive surgery plus hyperthermic intraperitoneal (CRS/HIPEC) between...
Safe implementation and thorough evaluation of new treatments require prospective data monitoring standardization treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment patients with peritoneal disease an increasing number suggested drug regimens. The aim was to reach expert consensus on current PIPAC protocols define most important research topics.The panel included active centers, organizers courses principal investigators studies...