A5039120517- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Knee injuries and reconstruction techniques
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- Science, Research, and Medicine
- Tendon Structure and Treatment
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Tumors and Oncological Cases
- Medical Imaging and Pathology Studies
- Prostate Cancer Diagnosis and Treatment
University Hospital of Zurich
2015-2025
University of Zurich
2014-2025
Charité - Universitätsmedizin Berlin
2024
ORCID
2022
University of Bern
2003-2021
Cornell University
2015-2019
Weill Cornell Medicine
2015-2019
Scripps Research Institute
2011-2018
New York Hospital Queens
2015-2018
Presbyterian Hospital
2015-2018
Abstract Precision medicine is an approach that takes into account the influence of individuals' genes, environment, and lifestyle exposures to tailor interventions. Here, we describe development a robust precision cancer care platform integrates whole-exome sequencing with living biobank enables high-throughput drug screens on patient-derived tumor organoids. To date, 56 tumor-derived organoid cultures 19 xenograft (PDX) models have been established from 769 patients enrolled in...
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated obesity and an increased risk colorectal cancer. Whether HFCS contributes directly to tumorigenesis unclear. We investigated the effects daily oral administration in adenomatous polyposis coli (APC) mutant mice, which are predisposed develop intestinal tumors. The HFCS-treated mice showed a substantial increase tumor size grade absence metabolic syndrome. concentrations fructose glucose lumen...
Abstract A major hurdle in the study of rare tumors is a lack existing preclinical models. Neuroendocrine prostate cancer an uncommon and aggressive histologic variant that may arise de novo or as mechanism treatment resistance patients with pre-existing castration-resistant cancer. There are few available models to neuroendocrine Here, we report generation characterization tumor organoids derived from needle biopsies metastatic lesions four patients. We demonstrate genomic, transcriptomic,...
<h3>Importance</h3> Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up clinical functional validation both common low-frequency mutations. We describe a whole-exome sequencing (WES) precision medicine trial focused on patients with advanced cancer. <h3>Objective</h3> To understand how WES data affect therapeutic decision making in cancer identify novel biomarkers response. <h3>Design, Setting, Patients</h3> Patients...
Abstract Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation the cGAS–STING innate immune pathway. How tumors co-opt inflammatory signaling while evading surveillance remains unknown. Here, we show that ectonucleotidase ENPP1 promotes metastasis by selectively degrading extracellular cGAMP, an immune-stimulatory metabolite whose breakdown products include suppressor adenosine. loss suppresses metastasis, restores tumor...
The development and patterns of spontaneous age-related changes in the anterior cruciate ligament (ACL) their relationship to articular cartilage degeneration are not well characterized. This study was undertaken investigate types temporal sequence ACL determine correlation with lesion at all stages osteoarthritis (OA) human knee joints without prior joint trauma.Human (n = 120 from 65 donors ages 23-92) were obtained autopsy, ACLs graded macroscopically histologically. Inflammation...
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that particularly prevalent nonsmall cell lung (NSCLC). Loss results functional impairments increased mortality. aim present study was to characterize changes metabolism genetically engineered mouse model NSCLC. We show portion these animals develop loss muscle, tissue, inflammatory markers mirroring human syndrome. Using noncachexic...
CUPISCO is an ongoing randomized phase II trial (NCT03498521) comparing molecularly guided therapy versus platinum-based chemotherapy in patients newly diagnosed with "unfavorable" cancer of unknown primary (CUP).Patients unfavorable CUP diagnosis, as defined by the European Society Medical Oncology (ESMO), and available tissue for molecular sequencing are generally eligible. Potential entering screening undergo a review involving reference histopathology clinical work-up central eligibility...
Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies urgently needed. Here, we establish human PDAC organoid biobank from 31 genetically distinct lines, covering representative range tumor subtypes, and demonstrate that these reflect molecular phenotypic heterogeneity primary tissue. We use CRISPR-Cas9 genome editing drug screening to characterize drug-gene interactions with ARID1A BRCA2. find missense- but not frameshift mutations in...
To identify novel genes and pathways specific to the superficial zone (SZ), middle (MZ), deep (DZ) of normal articular cartilage.Articular cartilage was obtained from knees 4 human donors. The zones were dissected on a microtome. RNA analyzed genome arrays. zone-specific DNA array data tissue compared bovine cartilage. Genes differentially expressed between evaluated using direct annotation for structural or functional features, by enrichment analysis integrated functions.The greatest...
Abstract Background Multimodal treatment, including systemic treatment and surgery, improved the prognosis of peritoneal metastasis (PM). Despite all efforts, recurrence rates remain high, little data are available about clinical behavior or molecular patterns PM in comparison to hematogenous metastasis. Here, we aimed analyze after multimodal for from colorectal cancer. Methods Patients with undergoing chemotherapy cytoreductive surgery plus hyperthermic intraperitoneal (CRS/HIPEC) between...