A5101651117- Cancer-related molecular mechanisms research
- Protein Structure and Dynamics
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Enzyme Structure and Function
- Plant Pathogens and Fungal Diseases
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Microplastics and Plastic Pollution
- Metabolism, Diabetes, and Cancer
- Microtubule and mitosis dynamics
- Peroxisome Proliferator-Activated Receptors
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Lipids, and Metabolism
- Plant-Microbe Interactions and Immunity
- Genetics, Bioinformatics, and Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Kruppel-like factors research
Ningxia Medical University
2017-2024
Chongqing Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Columbia University Irving Medical Center
2014-2022
Guangdong Institute for Drug Control
2022
Peking University
2022
Yunnan University
2016-2021
Harbin Medical University
2020
Wannan Medical College
2020
First Affiliated Hospital of Wannan Medical College
2020
Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by variety of clinical features, including anovulation, hyperandrogenism, and ovarian abnormalities, resulting in infertility. PCOS affects approximately 6%–15% all reproductive-age women worldwide. Metformin, popular drug used to treat patients, has beneficial effects reducing hyperandrogenism inducing ovulation; however, the mechanisms which metformin ameliorates are not clear. Hence, we aimed explore treating...
Abstract B-cell malignancies routinely express surface antigens CD19 and CD22. Immunotoxins against both have been evaluated, the immunotoxins targeting CD22 are more active. To understand this disparity in cytotoxicity guide screening of therapeutic targets, we compared two immunotoxins, FMC63(Fv)-PE38–targeting RFB4(Fv)-PE38 (BL22)–targeting Six lymphoma cell lines 4- to 9-fold binding sites per for than CD22, but BL22 is 140-fold active FMC63(Fv)-PE38, although they a similar affinity...
During the investigation of endophytic fungi diversity in aquatic plants and fungal soil southwest China, we obtained 208 isolates belonging to Trichoderma, including 28 as endophytes from 180 saprobes soil, respectively. Finally, 23 new species Trichoderma are recognized by further studies. Their phylogenetic positions determined sequence analyses combined partial sequences translation elongation factor 1-alpha (tef1) gene encoding second largest nuclear RNA polymerase subunit (rpb2). The...
T lymphocyte and macrophage infiltration in the aortic wall is critical for abdominal aneurysm (AAA). However, how lymphocytes interact with macrophages pathogenesis of AAA remains largely uncharacterized. In an elastase-induced murine model, we first found that expression pyruvate kinase muscle isozyme 2 (PKM2), last rate-limiting enzyme glycolysis, was increased infiltrated vascular lesions. lymphocyte-specific PKM2 deficiency mice (LckCrePKM2fl/fl) or intraperitoneal administration...
Di-(2-ethylhexyl) phthalate (DEHP) is widely used in various plastics but has been demonstrated to cause female reproductive toxicity. However, the exact mechanism underlying ovarian damage induced by DEHP remains unclear. In this study, was administered orally 5-week-old mice for 30 days at doses of 0, 250, 500, and 1000 mg/kg/day. The findings that exposure disrupted function follicular development as well oxidative stress autophagy granulosa cells (GCs). Further, 200 µM...
Premature ovarian failure (POF) is one of the leading causes female infertility and accompanied by abnormal endocrine, seriously affecting quality life. Previous studies have demonstrated that mesenchymal stem cells (MSCs) transplantation a promising therapeutic strategy for POF. However, mechanism remains obscure. This study aims to investigate effect human umbilical cord-derived (hUC-MSCs) on function in POF rat model explore underlying mechanisms.The was evaluated morphology, histology,...
// Ying-Ka Ingar Lau 1 , Xing Du Vinayak Rayannavar Benjamin Hopkins 3 Jacquelyn Shaw 1, 4 Eliana Bessler Tiffany Thomas 5 Maira M. Pires Megan Keniry 3, 6 Ramon E. Parsons Serge Cremers Matthias Szabolcs 7 Matthew A. Maurer 2 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032 Department of Medicine, Icahn School Medicine at Mount Sinai, 10029 Current address, Albert Einstein College Bronx, 10461 Institute for Clinical and Translational Research, Biology...
Microplastics (MPs) and nanoplastics (NPs) are novel environmental pollutants that ubiquitous in the environment everyday life. NPs can easily enter tissues have more significant potential health risks due to their smaller diameter. Previous studies shown induce male reproductive toxicity, but detailed mechanisms remain uncertain. In this study, intragastric administration treated mice with polystyrene (PS-NPs, 50, 90 nm) at 3 15 mg/mL/day doses for 30 days. Then, fresh fecal samples were...
To elucidate the potential function of long non-coding RNA (lncRNA) TUG1 in progression diabetic nephropathy (DN) and underlying mechanism.Rat diabetes mellitus (DM) model was established by streptozocin (STZ) administration. In vivo levels relative genes phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway DM rats control were determined quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Moreover, kidney weight, 24 h-urine protein, blood urea nitrogen serum...
Bcl-2 inhibits cell proliferation by delaying G0/G1 to S phase entry. We tested the hypothesis that regulates entry through mitochondrial pathways. Existing evidence indicates adenosine tri-phosphate (ATP) and reactive oxygen species (ROS) are important signals in survival death, however, molecular details of how these 2 processes linked remain unknown. In this study, lines stably expressing Bcl-2, 3T3Bcl-2 C3HBcl-2, vector-alone PB controls were arrested serum starvation contact inhibition,...
Fungi in the genus Trichoderma are widely distributed China, including Yunnan province. In this study, we report three new soil-inhabiting species , named as T.kunmingense T.speciosum and T.zeloharzianum . Their colony mycelial morphology, features of asexual states, were described. For each species, their DNA sequences obtained from loci, internal transcribed spacer (ITS) regions ribosomal DNA, translation elongation factor 1-α encoding gene (tef1) second largest nuclear RNA polymerase...
The CKS1B gene located on chromosome 1q21 is frequently amplified in breast, lung, and liver cancers. codes for a conserved regulatory subunit of cyclin-CDK complexes that function at multiple stages cell cycle progression. We used high throughput screening protocol to mimic cancer-related overexpression library Saccharomyces cerevisiae mutants identify genes whose functions become essential only when CKS1 overexpressed, synthetic dosage lethal (SDL) interaction. Mutations affecting mitotic...
Abstract Background Human umbilical cord-derived MSCs (hUC-MSCs) have been identified as promising seeding cells in tissue engineering and clinical applications of regenerative medicine due to their advantages simple acquisition procedure the capability come from a young donor over other sources. In applications, large scale production is required optimal cryopreservation culture conditions are essential autologous allogeneic transplantation future. However, influence cryopreserved post-thaw...
The physicochemical bases for enzyme cold-adaptation remain elusive.