A5077386061- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Congenital gastrointestinal and neural anomalies
- Stoma care and complications
- Hernia repair and management
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Bowel Disease
- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Gastrointestinal motility and disorders
- Cardiac Arrest and Resuscitation
- Health disparities and outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Molecular Biology Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Coronary Interventions and Diagnostics
Imperial College London
2016-2025
Cleveland Clinic London
2022-2025
University of Ulster
2010-2024
Imperial College Healthcare NHS Trust
2016-2023
Royal Victoria Infirmary
2019
St Mark's Hospital
2015-2018
Mayo Clinic in Florida
2015-2017
St Mary's Hospital
2016-2017
St Mary's Hospital
2017
St Mary's Hospital
2016
Safe implementation and thorough evaluation of new treatments require prospective data monitoring standardization treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment patients with peritoneal disease an increasing number suggested drug regimens. The aim was to reach expert consensus on current PIPAC protocols define most important research topics.The panel included active centers, organizers courses principal investigators studies...
BACKGROUND: Sacral nerve stimulation has been shown to be an effective treatment for fecal incontinence and early studies reported success rates of 67% 100%. However, “success” arbitrarily set at a 50% reduction in symptoms, data are rarely with “intention treat.” OBJECTIVE: This study aimed assess the true efficacy sacral compared published literature. DESIGN: prospective 5-year was conducted 50 patients treated stimulation. All analyses were performed on intention-to-treat basis. SETTINGS:...
In Brief Objectives: The aim of this study was to assess the long-term efficacy percutaneous tibial nerve stimulation (PTNS) in fecal incontinence (FI). Background: There is extensive evidence regarding PTNS urinary incontinence. Data on for FI are limited a few small case series with relatively short-follow up. Methods: A prospective cohort patients studied. Incontinence scores were measured using validated questionnaire (Cleveland Clinic Florida–FI score) at specific time points: before...
Abstract Epigenetic alterations co-evolve with genetic mutations to drive carcinogenesis and treatment response. Resolving genome-epigenome coevolution requires accurate multi-omic single cell measurement. Here we develop a new technology called “double ATAC” (dATAC) for high-throughput, high-quality, concurrent whole genome sequencing chromatin accessibility profiling of individual somatic cells. dATAC is “one pot” method that uses two rounds tagmentation sequentially label open regions...
A family history of appendicectomy was sought in two groups children admitted to Llandough Hospital over sixteen months. The study group consisted 29 with histologically confirmed acute appendicitis, while the control for reasons unrelated abdominal pain. elicited first-degree relatives--that is, siblings and parents 20 four controls--a statistically significant difference. results obtained from this suggest that a familial predisposition appendicitis exists.
The APPEAR procedure was developed to allow sphincter-preserving rectal resection for both benign and malignant pathology, which would traditionally require abdominoperineal excision or completion proctectomy, if treated by conventional means. This clinical trial (clinicaltrials.gov: NCT00534131) evaluated the short-term physiological results of this procedure.Fourteen patients were enrolled, 7 with neoplasia, 5 ulcerative colitis, 2 traumatic damage. Patients preoperatively, at a median...
Conflicting data exist on the contributions of advancing age and childbirth structure function anal sphincter. This study aimed to examine relative in a large cohort women referred for investigation symptoms colorectal dysfunction (fecal incontinence constipation).This was conducted at specialist surgical unit university teaching hospital.Retrospective analysis performed prospectively collected demographic, symptom profile, physiologic from 3686 female patients. Strict exclusion criteria...
Endoscopic surveillance of patients with ulcerative colitis aims to prevent cancer-related morbidity through the detection and treatment dysplasia. The literature date varies widely regard importance dysplasia as a marker for colorectal cancer at time colectomy.The aim this study was accurately characterize extent which preoperative is associated undetected in colitis.A retrospective chart review conducted undergoing surgery within Mayo Clinic Health System between August 1993 July...
Percutaneous tibial nerve stimulation and sacral are both second-line treatments for fecal incontinence, but the comparative efficacy of 2 therapies is unknown. In our institution, patients with refractory incontinence generally treated percutaneous before being considered stimulation.The aim this study was to assess outcome associated treatment algorithm in order guide future management strategies.All over a 3-year period receiving were identified from prospectively recorded database....
Rectal intussusception may be the initial abnormality of a progressive pelvic floor disorder culminating in external prolapse. The evidence, however, is unclear, and pathophysiological mechanisms underlying this condition are unknown.The aim study to identify relationship between age, symptom duration, anorectal physiology parameters, type intussusception/prolapse order appreciate natural history condition.All female patients diagnosed proctographically with rectorectal/rectoanal or prolapse...