A5048942702- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Abdominal Trauma and Injuries
- Organ Donation and Transplantation
- Sepsis Diagnosis and Treatment
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
- Neonatal Respiratory Health Research
- Thermal Regulation in Medicine
- Abdominal Surgery and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Acute Kidney Injury Research
- Patient Safety and Medication Errors
- Venous Thromboembolism Diagnosis and Management
- Trauma and Emergency Care Studies
- Hernia repair and management
- Regulation of Appetite and Obesity
- Bariatric Surgery and Outcomes
Northwell Health
2013-2024
Lenox Hill Hospital
2022-2024
Hofstra University
2014-2023
North Shore University Hospital
2010-2023
Long Island Jewish Medical Center
2010-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2017-2023
Marcus (United States)
2022
SUNY Downstate Health Sciences University
2021
Northeast Georgia Medical Center
2021
Medical Research Institute
2021
In this review of a collected series patients undergoing hepatic resection for colorectal metastases, 100 were found to have survived greater than five years from the time resection. Of these long-term survivors, 71 remain disease-free through last follow-up, 19 recurred prior years, and ten after years. Patient characteristics that may contributed survival examined. Procedures performed included trisegmentectomies, 32 lobectomies, 16 left lateral segmentectomies, 45 wedge resections. The...
Necrotizing fasciitis has been associated with significant morbidity and mortality. Thirty-three patients were studied over a 3-year period. Predisposing factors included intravenous drug abuse (30%), diabetes (21%), obesity (18%). Severe pain (94%) abnormal temperature (88%) present, whereas laboratory data x-ray nonspecific. Gram-positive organisms most frequently recovered (B-hemolytic streptococcus 45%). Treatment consisted of antibiotics, surgical debridement, re-exploration 24 hours...
Several significant advances in the treatment of hepatic injuries have evolved over past decade. These trends been incorporated into overall strategy and are reflected experiences with 411 consecutive patients. Two hundred fifty-eight patients (63%) minor (grades I to II) were treated by simple suture or hemostatic agents a mortality rate 6%. One twenty-eight (31%) sustained complex III V). seven (83.5%) grades IV injury underwent portal triad occlusion finger fracture parenchyma alone....
The most important concept emerging from the management of complex hepatic trauma is that direct suture ligation severed blood vessels and bile ducts effective treatment. Three essential maneuvers are necessary: (1) use finger fracture technique to expose laceration widely, so individual can be accomplished under vision; (2) occluding portal triad for 20 60 minutes; (3) closure incision over a viable omental pedicle. Two hundred consecutive patients with injuries were treated at Trauma Shock...
The pathogenesis of stroke involves inflammation, apoptosis, and excitotoxicity, which is mediated in part by neuronal NO synthase (nNOS) activation. Ghrelin, an endogenous 28-amino acid peptide, shown to exert antiapoptotic anti-inflammatory properties. However, the effect ghrelin permanent focal cerebral ischemia role vagus nerve its action remain unknown. To study this, male adult Sprague-Dawley rats underwent right-sided middle artery occlusion (MCAO) with or without prior bilateral...
Cold-inducible RNA-binding protein (CIRP) is a nuclear that has been recently identified as novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized CIRP acts potent hepatic ischemia-reperfusion (I/R), thus blocking protects against I/R-induced liver injury. Male C57BL/6 mice were subjected to 70% ischemia by microvascular clamping of the hilum left median lobes for 60 min, followed reperfusion. Anti-CIRP antibody (1 mg/kg body weight) or vehicle (normal saline) 0.2 mL...
COPPA, GENE F. M.D; ENG, KENNETH. M.D.; C RANSON, JOHN H. B.M., B.GH.; GOUGE, THOMAS LOCALIO, S. ARTHUR M.D. Author Information
Background Renal ischemia-reperfusion (I/R) is a major contributor to delayed graft function after renal transplantation. The pathophysiology of I/R can be summarized by primary energy deficit during ischemia and secondary phase oxidative stress inflammation. Sirtuin 1 an energy-sensing enzyme involved in regulating multiple cellular functions. We hypothesized that stimulating would increase mitochondrial biogenesis thereby enhancing metabolism attenuating I/R-induced injury. Methods Adult...
Although microRNAs regulate mRNA expression intracellularly, they are often released into the circulation in inflammatory diseases. During sepsis, secreted extracellular cold-inducible RNA-binding protein (eCIRP) acts as a damage-associated molecular pattern (DAMP), inducing tissue damage by elevating cytokines and chemokines. Here, we report that circulating microRNA 130b-3p inhibits eCIRP-mediated sterile cecal ligation puncture (CLP)-induced non-sterile inflammation. We find levels of...
Hepatic ischemia-reperfusion is a major clinical problem with limited treatment options. The pathophysiology of hepatic characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 an energy-sensing enzyme known to modulate biogenesis. We hypothesized that pharmacologic activation sirtuin protective after injury.Animal study.University-based experimental laboratory.Wild-type C57BL/6 mice.C57BL/6 mice were subjected 60-minute partial posttreated activator, SRT1720 (20...
During the past decade splenic salvage procedures rather than splenectomy have been considered preferred treatment for traumatic injuries. Splenic preservation has most often accomplished by splenorrhaphy and more recently a controversial nonoperative approach. This report delineates indications, contraindications, results with splenectomy, splenorrhaphy, based on an 11-year experience (1978 to 1989) in which 193 consecutive adult patients injuries were treated. One hundred sixty-seven...
From 1966 to 1981, 646 patients underwent resection for primary adenocarcinoma of the rectum by one surgeon (S.A.L.) in hospital. The operation, selected preoperative sigmoidoscopic measurement, was anterior (ASR) 320 patients, abdoninosacral 175 and abdomi-noperineal (APR) 151 patients. operative mortality rate 2% following each operations. Anastomotic complications occurred less than after AR 9.7% ASR. All were completely continent stool flatus Follow-up is complete 419 427 treated from...
Sepsis is an acute inflammatory condition that can result in multiple organ failure and lung injury. Growth arrest-specific protein 6 (Gas6) a broad regulator of the innate immune response involved with nuclear factor κB signaling pathway. We hypothesized Gas6 could have protective role attenuating severity injury sepsis. Male mice were subjected to sepsis by cecal ligation puncture (CLP) after which recombinant murine (rmGas6; 5 μg/mouse) or normal saline (vehicle) was administered...
ABSTRACT Extracellular cold-inducible RNA-binding protein (CIRP) functions as damage-associated molecular pattern and has been demonstrated to be responsible in part for the damage occurring after renal ischemia–reperfusion (I/R). A short peptide derived from CIRP, named C23, binds myeloid differentiation factor 2, a Toll-like receptor 4 coreceptor. We hypothesize that C23 reduces (RIR) injury by blocking CIRP. observed pretreatment with significantly decreased levels of recombinant mouse...