A5020003474- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Viral Infectious Diseases and Gene Expression in Insects
- Laser-induced spectroscopy and plasma
- Cancer Genomics and Diagnostics
- Laser Material Processing Techniques
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Ginger and Zingiberaceae research
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Advanced Surface Polishing Techniques
- Colorectal Cancer Treatments and Studies
- Neonatal Respiratory Health Research
Jiangsu University
2025
Richmond University Medical Center
2024-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Institute of Hematology & Blood Diseases Hospital
2023-2024
Agency for Science, Technology and Research
2016-2024
Chongqing University of Arts and Sciences
2024
Institute of Environment and Sustainable Development in Agriculture
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1996-2024
Current evidence suggests that a few global regulatory factors mediate many of the extensive changes in gene expression occur as Escherichia coli enters stationary phase. One metabolic pathways is transcriptionally activated phase pathway for biosynthesis glycogen. To identify regulate glycogen trans, collection transposon mutants was generated and screened mutations which independently increase or decrease levels plasmid-encoded glgC'-lacZ fusion. The excess mutation TR1-5 found to be...
Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for recurrence in these individuals remains poorly understood. Here, we demonstrate that RASAL2, which encodes RAS-GTPase–activating protein (RAS-GAP), is functional target anti-invasive microRNA-203 overexpressed subset or estrogen receptor–negative (ER-negative) tumors. As opposed to luminal B ER-positive cancers, RASAL2 has been shown act as RAS-GAP tumor...
Abstract Background Telomere length (TL) and its attrition are important indicators of physiological stress biological aging hence may vary among individuals the same age. This variation is apparent even in newborns, suggesting potential effects parental factors intrauterine environment on TL growing fetus. Methods Average relative TLs newborns (cord tissue, N = 950) mothers (buffy coat collected at 26–28 weeks gestation, 892) were measured a birth cohort. study provides comprehensive...
Sales pipeline win-propensity prediction is fundamental to effective sales management. In contrast using subjective human rating, we propose a modern machine learning paradigm estimate the of leads over time. A profile-specific two-dimensional Hawkes processes model developed capture influence from seller's activities on their win outcome, coupled with lead's personalized profiles. It motivated by two observations: i) sellers tend frequently focus selling and efforts few during relatively...
Interindividual variability in the epigenome has gained tremendous attention for its potential pathophysiological investigation, disease diagnosis, and evaluation of clinical intervention. DNA methylation is most studied epigenetic mark epigenome-wide association studies (EWAS) as it can be detected from limited starting material. Infinium 450K array popular platform high-throughput profiling this samples, cost-effective requires small amounts DNA. However, method suffers low genome coverage...
Previous studies on the risk factors for prolonged pleural effusion (PPE) have primarily focused surgical-related factors, with little research exploring influence of nutritional this delay. This study aimed to identify PPE in Chinese infants following congenital heart disease (CHD) surgery. We retrospectively reviewed medical records patients under 3 years old chylothorax CHD surgery from 2016 2020. was defined as lasting over 14 days. Logistical regression analysis conducted factors. Of...
In recent years, gastric cancer (GC) has become a major cause of mortality among various malignancies worldwide with high incidence rates. Long non-coding RNA (lncRNAs) may serve as oncogenes and tumor suppressors in cancers. Therefore, we investigated the effect LINC01314 on development GC cells relation to Wnt/β-catenin signaling pathway. Microarray data analysis was conducted screen GC-related differentially expressed lncRNAs, followed by determination binding interaction between...
Clear cell renal carcinoma (ccRCC) is a frequent malignant tumor of the kidney which has dismal prognosis. At present, targeted therapies and immunotherapy have achieved significant results; however, overall survival rate patients with ccRCC remains unacceptably poor. It therefore necessary to find novel therapeutic diagnostic targets for ccRCC. been reported that enolase 2 (ENO2) an oncogene, although its function in immune microenvironment growth yet be fully elucidated. The present study...
We demonstrated previously that extracellular vesicles (EVs) released from mesenchymal stem cells (MSCs) play a critical role in angiogenesis. Here, we examine whether this pro-angiogenic efficacy is enhanced EVs derived MSCs overexpressing GATA-4 (MSCGATA−4). Methods and Results. were isolated MSCGATA-4 (EVGATA-4) control transduced with an empty vector (EVnull). both cell types of the same size displayed similar molecular markers. Compared EVnull, EVGATA-4 increased tube-like structure...
The correlation between FOXM1 and KIF20A has not been revealed in clear cell renal carcinoma (ccRCC).Public data was downloaded from Cancer Genome Atlas (TCGA) database. R software utilized for the execution of bioinformatic analysis. expression levels specific molecules (mRNA protein) were detected using real-time quantitative PCR (qRT-PCR) Western blot assays. capacity growth assessed by employing CCK8 colony formation assay. Cell invasion migration ability transwell assay.In our study, we...
The emergence of antibiotic-resistant Helicobacter pylori is concern in the treatment H. pylori-associated gastroduodenal diseases. As organism was reported to bind gastric mucin, we used porcine mucin as substrate assess antiadhesive property polysaccharides derived from Spirulina (PS), a commercially available microalga, against binding mucin. Results show that prevented optimally at pH 2.0, without affecting viability either bacteria or epithelial cells, thus favouring its action...
Objective We performed experiments using Neuregulin-1β (NRG-1β) treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions (GJs) during heart failure (HF). Methods Rat models of HF were established aortocaval fistula. Forty-eight rats divided randomly into (HF, n = 16), NRG-1β (NRG, and sham operation (S, 16) group. The in NRG group administered (10 μg/kg per day) 7 days via tail vein, whereas other groups injected with same...
L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral acids. The aspartate-modified (Asp-DOX) showed highest affinity (Km = 41.423 μmol/L) LAT1. Aspartate was attached N-terminal DOX amide bond with free carboxyl and group α-carbon atom Asp residue. product Asp-DOX...